IDENTIFICATION OF C05C89 INTERACTING PROTEINS

C05C89 相互作用蛋白的鉴定

• 批准号: 8171386
• 负责人: Karen F Oegema
• 金额: $ 0.24万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171386
• 关键词: Cell physiology; Centrioles; Centrosome; Cilia; Computer Retrieval of Information on Scientific Projects Database; Funding; Goals; Grant; Institution; Microtubule Stabilization; Organelles; Preparation; Proteins; Research; Research Personnel; Resources; Source; United States National Institutes of Health; interest; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Centrioles are small cylindrical organelles that are important in the stabilization of microtubules which perform several important cellular functions including centrosome assembly and cilia formation. Understanding how centrioles perform these different functions is of great interest. The goal of this project is to identify C05C8.9 interacting proteins. C05C8.9 is a novel centriolar protein that was identified in a TAP preparation of SAS-4 which is required for cilia formation.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 中心粒是小的圆柱形细胞器，对于微管的稳定非常重要，微管执行多种重要的细胞功能，包括中心体组装和纤毛形成。 了解中心粒如何执行这些不同的功能非常有趣。该项目的目标是鉴定 C05C8.9 相互作用蛋白。 C05C8.9 是一种新型中心粒蛋白，在纤毛形成所需的 SAS-4 的 TAP 制剂中被鉴定。