CARDIOVASCULAR AND HIV/AIDS EFFECTS ON BRAIN STRUCTURE/FUNCTION AND COGNITION

心血管和艾滋病毒/艾滋病对大脑结构/功能和认知的影响

基本信息

批准号：
8171192
负责人：
JAMES T. BECKER
金额：
$ 0.95万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-01 至 2011-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8171192
关键词：
AIDS/HIV problem Acquired Immunodeficiency Syndrome Address Affect Age Aging Anatomy Area Attention Blood flow Brain Calcium Cardiovascular Abnormalities Cardiovascular Diseases Cardiovascular system Cerebrovascular Circulation Clinical Cognition Cognitive Cohort Studies Computer Retrieval of Information on Scientific Projects Database Coronary Data Dementia Development Diffusion Disease Elderly Functional disorder Funding Grant HIV HIV Infections Image Institution Life Link Magnetic Resonance Imaging Modeling Neurocognitive Participant Pathway interactions Persons Relative (related person)Research Research Personnel Resources Rosa Series Severities Source Spectrum Analysis Structure Syndrome Thick United States National Institutes of Health clinical care cognitive function gray matter intima media men neuropsychiatry neuropsychological treatment strategy white matter

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proportion of persons living with HIV/AIDS who are over 50 rose to 22.5% of all cases in 2004. Our lack of understanding about how age and HIV/AIDS interact is becoming increasingly problematic, no more so than in the area of the neurocognitive manifestations of AIDS, since age is itself an important predictor of neurocognitive syndromes. In spite of the known links between age and various neuropsychiatric disorders - including dementia - it has only been recently that much attention has been paid to the possible interactions between HIV/AIDS, aging and neuropsychiatric presentation. The purpose of this application is to obtain funding to compare and contrast brain structural and functional abnormalities associated with HIV/AIDS as a function of cardiovascular abnormalities. As the rate of cardiovascular disease increases with age, so too do the consequences of those disorders including small vessel abnormalities in the brain, decreased grey matter volume, altered white matter integrity, and changes in regional cerebral blood flow. Understanding how these normal consequences of aging are affected by HIV is important for clinical care, the development of new treatment strategies, and understanding the pathophysiology of HIV-Associated Neurocognitive Disorder. We will evaluate the cardiovascular, cognitive, and brain structure/function status of 340 men participating in the cardiovascular substudy of the Multicenter AIDS Cohort Study (MACS). We will take advantage of the nearly 25 years of prior clinical and neuropsychological data, combined with the new CVD variables (e.g., coronary calcium, carotid intima-media thickness) and MRI findings (anatomic, diffusion imaging, blood flow, and spectroscopy) to address a series of linked hypotheses concerning brain structural and functional abnormalities, and their relationship to CVD variables, HIV serostatus, and markers of the severity of the HIV infection. We will evaluate this model by using both cross-sectional and longitudinal data from the study participants who range in age from 50 to 75 years old. We propose that HIV and CVD have direct effects on brain structure/function, and that CNS integrity is the direct link to cognitive functions; CVD is itself predicted by advancing age. We predict that HIV infection moderates the strength of the pathway between CVD and brain structure. That is, the effects of CVD on brain structure/function will be augmented in the HIV-infected men relative to the uninfected men.

该子项目是利用该技术的众多研究子项目之一资源由 NIH/NCRR 资助的中心拨款提供。子项目和研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金，因此可以在其他 CRISP 条目中表示。列出的机构是对于中心来说，它不一定是研究者的机构。 2004 年，50 岁以上的艾滋病毒/艾滋病感染者占所有病例的比例上升到 22.5%。我们对年龄和艾滋病毒/艾滋病如何相互作用缺乏了解，这一问题正变得越来越严重，尤其是在神经认知领域。艾滋病的表现，因为年龄本身就是神经认知综合征的重要预测因素。尽管年龄与各种神经精神疾病（包括痴呆症）之间的联系已为人所知，但直到最近，艾滋病毒/艾滋病、衰老和神经精神表现之间可能存在的相互作用才引起人们的广泛关注。本申请的目的是获得资金来比较和对比与艾滋病毒/艾滋病相关的大脑结构和功能异常作为心血管异常的函数。随着心血管疾病的发病率随着年龄的增长而增加，这些疾病的后果也随之增加，包括大脑中的小血管异常、灰质体积减少、白质完整性改变以及局部脑血流变化。了解艾滋病毒如何影响衰老的这些正常后果对于临床护理、新治疗策略的开发以及了解艾滋病毒相关神经认知障碍的病理生理学非常重要。我们将评估参与多中心艾滋病队列研究 (MACS) 心血管亚研究的 340 名男性的心血管、认知和大脑结构/功能状态。我们将利用近 25 年的临床和神经心理学数据，结合新的 CVD 变量（例如冠状动脉钙、颈动脉内膜中层厚度）和 MRI 结果（解剖学、扩散成像、血流和光谱学）来提出了一系列有关大脑结构和功能异常及其与 CVD 变量、HIV 血清状态和 HIV 感染严重程度标记的关系的相关假设。我们将使用年龄在 50 岁至 75 岁之间的研究参与者的横截面和纵向数据来评估该模型。我们认为 HIV 和 CVD 对大脑结构/功能有直接影响，中枢神经系统完整性与认知功能有直接联系； CVD本身是通过年龄增长来预测的。我们预测 HIV 感染会调节 CVD 和大脑结构之间通路的强度。也就是说，相对于未感染的男性，艾滋病毒感染者的 CVD 对大脑结构/功能的影响将会增强。