NHLBI Pediatric Translational Consortium Administrative Coordinating Center

NHLBI 儿科转化联盟行政协调中心

• 批准号: 8424991
• 负责人: SHARON L TENNSTEDT
• 金额: $ 875.66万
• 依托单位: NEW ENGLAND RESEARCH INSTITUTES, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8424991
• 关键词: Address; Advisory Committees; Area; Basic Science; Bioinformatics; Cardiac; Cardiology; Cardiovascular Diseases; Case Report Form; Certification; Childhood; Clinic; Clinical; Clinical Research; Clinical Trials; Collaborations; Communication; Complex; Conduct Clinical Trials; Congenital Heart Defects; Consent Forms; Data; Data Coordinating Center; Data Quality; Databases; Development; Electronic Mail; Electronics; Environment; Fostering; Funding; Genetic; Genomics; Goals; Heart; Human; Image; Information Systems; Instruction; Laboratories; Lead; Leadership; Mails; Maintenance; Methodology; Molecular; Monitor; National Heart, Lung, and Blood Institute; Pathway interactions; Persons; Physiological; Preparation; Principal Investigator; Probability; Procedures; Process; Program Development; Protocols documentation; Qualifying; Quality Control; Recording of previous events; Relative (related person); Reporting; Research; Research Personnel; Research Support; Resources; Role; Schedule; Scientist; Services; Sum; Teleconferences; Telephone; Training; Translational Research; Translations; Work; data management; design; experience; innovation; meetings; member; payment; programs; symposium; web site

DESCRIPTION (provided by applicant): The NHLBI Translational Program in Pediatric Cardiovascular Disease will encourage and facilitate translation of results from basic science to clinical research and to provide clinic input to needs for basic research. The Program will consist of the Pediatric Cardiac Genomics Consortium and the Cardiac Development Consortium supported by the Administrative Coordinating Center (ACC). Each Consortium will function independently but will interact with each other as well as with the NHLBI Pediatric Heart Network. Key areas of ACC responsibility and function include provision of logistical and support services; management and distribution of Consortia funds to support Research Cores; and provision of electronic information and communication services. In addition, study activities in the Pediatric Cardiac Genomics Consortium will be supported by the PHN DCC, i.e. harmonization of protocols and consent forms across the Consortium, development and programming of case report forms; training and certification of Research Center staff in conduct of Consortium studies, management of clinical research data, and quality control activities. NERI is uniquely qualified to serve as the ACC for this initiative. Most relevant, NERI has served most effectively as the Pediatric Heart Network Data Coordinating Center (PHN DCC) since its inception in 2001. NERI's contributions to the PHN have been significant and varies has encompass numerous administrative accomplishments that are highly relevant to the ACC, as well as other scientific, statistical, and technical accomplishments. The proposed leadership of the ACC consists of key investigators with the same leadership roles in the PHN DCC who will bring extensive, directly related, and highly complementary administrative, research and clinical experience in pediatric cardiology. NERI has a long history of coordinating center work (31 DCCs) that has allowed for greater efficiency and sharing of approaches for administrative procedures unique to clinical research networks as well as innovative data management, development of public and administrative websites, and methodologies for designing and analyzing clinical studies and trials and complex longitudinal data. In sum, NERI's scientific environment contributes substantially to the probability of successful completion of the activities of this Translational Program in Pediatric Cardiovascular Disease, including successful alignment with the Pediatric Heart Network. RELEVANCE (See instructions): The NHLBI translational program in pediatric cardiovascular disease consists of two research consortia whose work will lead to enhanced understanding of the molecular, cellular, and physiologic mechanisms responsible for healthy development and the relative contribution of genetic influences to the formation of cardiac defects in humans. Collaboration and integration of the work of the NHLBI Pediatric Heart Network will provide the pathway for the translation of research findings from these two Consortia to the conduct of clinical trials.

描述（由申请人提供）： 小儿心血管疾病的NHLBI转化计划将鼓励和促进基础科学结果转化为临床研究，并为基础研究需求提供临床投入。该计划将包括小儿心脏基因组学联盟和由行政协调中心（ACC）支持的心脏发展联盟。每个财团将独立起作用，但会相互作用，并与NHLBI小儿心脏网络相互作用。 ACC责任和功能的关键领域包括提供后勤和支持服务；财团资金的管理和分配以支持研究核心；并提供电子信息和通信服务。此外，PHN DCC将支持小儿心脏基因组学联盟中的研究活动，即在整个财团中协议和同意书的协调，案例报告表的发展和编程；研究中心工作人员的培训和认证在财团研究，临床研究数据管理和质量控制活动中的培训和认证。 Neri具有独特的资格，可以作为该计划的ACC。自2001年成立以来，最相关的是，NERI最有效地成为小儿心脏网络数据协调中心（PHN DCC）。NERI对PHN的贡献很重要，各种各样的行政成就涵盖了与ACC高度相关的许多行政成就，以及其他科学，统计，统计，统计和技术成就。 ACC的拟议领导由PHN DCC中具有相同领导角色的主要调查员组成，他们将带来广泛，直接相关且高度互补的行政，研究和临床经验。 NERI在协调中心工作（31 DCC）的历史悠久，该工作允许提高效率并共享用于临床研究网络独有的行政程序以及创新数据管理，公共和行政网站的开发以及设计和分析临床研究和试验和复杂的长期数据的方法。总而言之，NERI的科学环境对成功完成该转化计划在儿科心血管疾病中的活动的可能性很大，包括成功与儿科心脏网络的一致性。相关性（请参阅说明）：小儿心血管疾病中的NHLBI转化计划由两个研究联盟组成，其工作将增强对负责健康发展的分子，细胞和生理机制的了解，以及对健康发展的相对贡献，以及遗传影响对人类心脏缺陷的形成。 NHLBI小儿心脏网络工作的协作和整合将为从这两个财团转化为临床试验的进行研究结果提供途径。