NEURAL BASIS OF RESILIENT READERS IN DYSLEXIA

阅读障碍患者适应能力强的读者的神经基础

• 批准号: 8169867
• 负责人: Joshua Heitzmann
• 金额: $ 1.23万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169867
• 关键词: 16 year old; Adolescent; Brain; Characteristics; Child; Cognitive; Comprehension; Computer Retrieval of Information on Scientific Projects Database; Dyslexia; Functional Magnetic Resonance Imaging; Funding; Grant; Gray unit of radiation dose; Inferior; Institution; Judgment; Left; Lobule; Methods; Parietal; Reader; Reading; Research; Research Personnel; Resources; Semantics; Source; Superior temporal gyrus; Text; United States National Institutes of Health; base; interest; morphometry; phonology; relating to nervous system; semantic processing; skills; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Only recently has it been explored that some dyslexic readers may classify as 'resilient readers' because of their average or above average text comprehension skills. Specific Aims: To investigate the neural basis of resilient readers, Methods: A total of 62 healthy native English speakers between 6-16 years of age (mean 13.4, standard deviation (SD) 2.6) participated in our study. Among them, 31 children were skilled readers and 31 were dyslexic readers with and without poor reading comprehension skills (15 and 16 children, respectively). We performed voxel-based morphometry (VBM) and examined differences in regional gray and white matter volume (GMV, WMV) in dyslexic adolescents with and without poor reading comprehension. We also performed phonological and semantic processing tasks utilizing functional magnetic resonance imaging (fMRI) to identify whether there were corresponding differences in brain activation. Results: Whole brain analysis of GMV regressing out total GMV showed significantly greater GMV in the left parieto-temporal region in the Dys[NormComp] compared to the Dys[PoorComp] Group (p<0.01 corrected). This cluster included two distinct peaks in the left posterior superior temporal gyrus (pSTG) and inferior parietal lobule (IPL). There were no significant differences in WMV. Post-hoc region-of-interest analysis showed significantly greater GMV in controls compared to Dys[NormComp] and Dys[PoorComp] combined (t(59)=2.09, p=0.04), but not compared to Dys[NormComp] only (t(59)=0.72, p=0.48). Corresponding to the cognitive characteristics, left parieto-temporal activation during rhyme judgment showed no significant difference between Dys[NormComp] and Dys[PoorComp], but Dys[NormComp] compared to Dys[PoorComp] showed significantly greater activation during semantic categorization in this region.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 介绍： 直到最近才发现，一些阅读困难的读者可能会因为他们的文本理解能力处于平均或高于平均水平而被归类为“有弹性的读者”。 具体目标： 为了研究有弹性的读者的神经基础， 方法： 共有 62 名年龄在 6-16 岁之间、以英语为母语的健康人士（平均值 13.4，标准差 (SD) 2.6）参与了我们的研究。 其中，31 名儿童为熟练阅读者，31 名儿童为阅读困难读者，阅读理解能力较差（分别为 15 名和 16 名）。我们进行了基于体素的形态测量（VBM），并检查了有或没有阅读理解能力差的阅读障碍青少年的区域灰质和白质体积（GMV，WMV）的差异。 我们还利用功能磁共振成像（fMRI）执行语音和语义处理任务，以确定大脑激活是否存在相应的差异。 结果： 回归总 GMV 的 GMV 全脑分析显示，与 Dys[PoorComp] 组相比，Dys[NormComp] 组左顶颞区的 GMV 显着更高（校正后的 p<0.01）。该簇包括左后颞上回 (pSTG) 和顶下小叶 (IPL) 的两个不同峰。 WMV 没有显着差异。事后感兴趣区域分析显示，与 Dys[NormComp] 和 Dys[PoorComp] 组合相比，对照组的 GMV 显着更高 (t(59)=2.09，p=0.04），但不与仅 Dys[NormComp] 相比（ t(59)=0.72，p=0.48)。 与认知特征相对应，在韵律判断过程中，Dys[NormComp]和Dys[PoorComp]之间的左顶颞叶激活没有显着差异，但与Dys[PoorComp]相比，Dys[NormComp]在该区域的语义分类过程中表现出明显更大的激活。