Comparative Biogerontology Core

比较生物老年学核心

• 批准号: 8122848
• 负责人: RICHARD A MILLER
• 金额: $ 9.34万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8122848
• 关键词: Age; Aging; Archives; Biochemical; Birds; Breeding; Canis familiaris; Cell Line; Cells; Cryopreserved Cell; Gerontology; Goals; Institution; Learning; Life; Lipids; Longevity; Mammals; Metals; Natural Selections; Property; Proteins; Resistance; Scientist; Stress; Sulfur Amino Acids; chelation; comparative; oxidation

Comparative Biogerontology Core: Richard Miller, Director The goal of the Comparative Biogerontology Core is to establish cryopreserved cell lines from multiple species of long-lived and short-lived birds and mammals, including long-lived and short-lived breeds of dogs, and to use these to learn more about the biochemical, biophysical, and cellular properties that are associated with exceptionally long lifespans as these have evolved under natural selection. The CBC cell archives are already being exploited by scientists at UM and at other institutions in studies of stress resistance, protein oxidation, lipid profiles, metal chelation, and sulfur amino acid metabolites as these relate to species and breed differences in aging rate and longevity.

比较生物老年学核心：Richard Miller，主任 比较生物老年学核心的目标是建立来自多种长寿和短命鸟类和哺乳动物（包括长寿和短命狗品种）的冷冻细胞系，并利用这些细胞系来了解更多有关生物化学的信息。 、生物物理和细胞特性与超长寿命相关，因为这些特性是在自然选择下进化的。 CBC 细胞档案已被密歇根大学和其他机构的科学家用于抗应激、蛋白质氧化、脂质谱、金属螯合和硫氨基酸代谢物的研究，因为这些与物种和品种有关 衰老速度和寿命的差异。