Complexity Loss, Aging and the Dynamics of Frailty

复杂性丧失、衰老和脆弱的动态

基本信息

批准号：
8526311
负责人：
Madalena D Costa
金额：
$ 23.53万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-01 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8526311
关键词：
Address Affect Aging American Award Biological Markers Biology of Aging Biomedical Engineering Blood Pressure Cognitive Complex Data Databases Development Elderly Equilibrium Erythrocytes Exhibits Faculty Fostering Functional disorder Funding Generic Drugs Goals Health Health Care Costs Health Status Heart Rate Human Impairment Incidence Instruction Measurement Measures Methods Morbidity - disease rate Musculoskeletal Equilibrium Nursing Homes Organ Pathologic Pathway interactions Peripheral Phase Physics Physiological Physiology Population Program Research Project Grants Property Public Health Research Research Personnel Research Training Rest Risk Series Stratification Syndrome System Testing Therapeutic Intervention Time Work base career follow-up frailty heart rhythm member mortality neuromuscular new technology novel strategies pressure programs response therapy design

项目摘要

This application constitutes the request to transition to the ROO phase of a K99 Pathway to Indepentdence Awarid aimed at fostering and expanding ail the inter-related components of a academic career in basic and applied aspects of human aging. Dr. IVladalena Costa's long-term research goals are: (i) to understand basic mechanisms of nonlinear biologic and physiologic control in health and their degradation with aging and frailty, (ii) to develop a new class of dynamical biomarkers that quantify integrative function and give information about pathophysiology not obtainable with traditional probes, and (iii) to determine the value of this new class of dynamical biomarlcers for risk stratification and the assessment of therapeutic interventions designed to reverse or retard pathologic aging. Her work is at the interfaces of statistical physics, bioengineering, physiology, and the biology of aging. Two emerging themes of this interdisciplinary work are that healthy systems, which are marked by robustness and adaptability, exhibit the most complex multiscale dynamics, and that aging and the frailty syndrome in particular, are marked by a loss of complex multiscale variability and adaptive capacity. Dr. Costa's K99 award has allowed her to become an independent investigator working at the interface between complex systems and the biologic of aging. Her specific research aims for the ROO phase as presented in the original proposal remain unchanged. Propelled by the foundational K99 training and research work. Dr. Costa is also pursuing a number of inter-related sub-projects as part of her coherent program as a full time faculty member. The specific aims are: 1) to elucidate nonlinear mechanisms of integrative physiologic control by developing dynamical biomarkers that quantify multiscale fluctuations; 2) to test the hypothesis that the dynamical complexity of physiologic regulatory mechanisms degrades with aging in representative systems ranging from the cellular to organ, and 3) to test the hypothesis that loss of complexity in physiologic systems over time can be predictive of overall health status degradation and subsequent development of frailty.

该应用程序构成过渡到K99途径的ROO阶段的要求 Awarid旨在促进和扩展基础学术生涯的相关组成部分人类衰老的应用方面。 Ivladalena Costa博士的长期研究目标是：（i）了解非线性的基本机制健康的生物和生理控制及其衰老和脆弱的降解，（ii）开发新的量化整合功能并提供有关病理生理学的信息的动态生物标志物类无法通过传统探针获得，并且（iii）确定这种新的动力学的价值用于风险分层的生物掌握和评估旨在逆转或延迟病理衰老。她的工作是统计物理学，生物工程，生理学和衰老生物学的界面。二这项跨学科工作的新兴主题是健康的系统，以鲁棒性为特征和适应能力，表现出最复杂的多尺度动力学，以及衰老和脆弱综合症特别是复杂的多尺度变异性和自适应能力的标志。 Costa博士的K99奖使她成为了在界面上工作的独立调查员在复杂的系统与衰老的生物学之间。她的具体研究目的是原始提案中提出的ROO阶段的目的保持不变。受到基础K99培训和研究工作的推动。 Costa博士也在追求许多作为全职教职员工的连贯计划的一部分，相互关联的子项目是一部分。具体目标是：1）通过开发动力学来阐明综合生理控制的非线性机制量化多尺度波动的生物标志物； 2）检验的假设是生理调节机制在代表性系统中随着细胞的衰老而降低和3）检验以下假设：随着时间的流逝，生理系统中复杂性的丧失可以是预测整体健康状况退化和随后的脆弱发展。