Center for Protein Structure and Function

蛋白质结构与功能中心

基本信息

批准号：
8471734
负责人：
FRANCIS S MILLETT
金额：
$ 104.29万
依托单位：
UNIVERSITY OF ARKANSAS AT FAYETTEVILLE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2015-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8471734
关键词：
Abnormal Cell Area Arkansas Binding Biomedical Research Centers of Research Excellence Chemistry Chromosomes Collaborations Collagen Core Facility Disease Drug Design Environment Epigenetic Process Equipment Faculty Funding Goals Grant Health Histones Hormones Human Injection of therapeutic agent Institutes Interdisciplinary Study Lead Link Malignant Neoplasms Mass Spectrum Analysis Mentors Molecular Mus Mutation NMR Spectroscopy National Center for Research Resources Nucleosomes Oncogenic Osteoporosis Parathyroid gland Phase Phosphotransferases Pilot Projects Post-Translational Protein Processing Production Proteins Proteomics Publishing Regulation Research Research Infrastructure Research Personnel Research Project Grants Research Support Scientist Signal Transduction Staging Strategic Planning Structure Techniques Tertiary Protein Structure Testing Training United States National Institutes of Health Universities Wages X-Ray Crystallography bone mass career cdc42 GTP-Binding Protein chemical synthesis density human disease improved member mutant new technology novel strategies programs protein function protein metabolite protein structure protein structure function ras Proteins rho

项目摘要

This is a proposal for Phase III support of the NCRR COBRE Center for Protein Structure and Function at the University of Arkansas, which was established in October, 2000 with Phase I NIH COBRE Grant 1 P20 RR15569- 01 and continued in September, 2005 with Phase II COBRE Grant 2 P20 RR015569-06. Protein structure and function is a central biomedical research area that has great potential for leading to improvements in human health. The Center supports thematically-linked multidisciplinary research projects involving junior faculty, mid-career faculty, and senior faculty with expertise in a broad range of techniques needed to study protein structure and function. The goals of the COBRE Center are to strengthen collaboration between investigators and allow them to develop promising new approaches to biomedical research in protein structure and function. The Center has made excellent progress since its establishment in October, 2000. Thirteen outstanding new faculty members have been hired, and core facilities in NMR spectroscopy, X-ray crystallography, mass spectrometry, large-scale protein production, and chemical synthesis have been established. The five research core facilities in the Center are highly interactive, allowing an investigator to develop a project through all stages from identifying specific proteins of biomedical significance, determining the structures of these proteins and how they interact with other proteins and metabolites, and in some cases designing drugs to treat diseases associated with altered function of the proteins. The strategic plan for Phase III of our COBRE Center during the next five years is (1) to maintain and strengthen the state-of-the-art COBRE research core facilities developed during phases I and II that are essential for the support of the research projects in the Center, and (2) to support research pilot projects and training components to sustain a collaborative, multidisciplinary research environment in protein structure and function. All of the research projects supported by our COBRE Center are directed toward obtaining a detailed molecular-level understanding of the structure and function of proteins that could lead to improved treatments for human disease. For example, the goal of one project is to develop and test a fused parathyroid hormone - collagen bindng domain protein for the treatment of osteoporosis.

这是阿肯色大学NCRR柯布雷蛋白质结构和功能中心的第三阶段支持的建议，该中心于2000年10月成立，II II II期Cobre Grant 2 P20 P20 RRRR015569-06。蛋白质结构和功能是一个中央生物医学研究领域，具有巨大的潜力，可以改善人类健康。该中心支持涉及初级教职员工，职业学院和高级教师的主题链接多学科研究项目，并具有研究蛋白质结构和功能所需的广泛技术。毛绒中心的目标是加强研究人员之间的合作，并允许他们开发有希望的新方法来蛋白质结构和功能方面的生物医学研究。自2000年10月成立以来，该中心取得了良好的进步。已聘请了13名新的新教师，并建立了NMR光谱，X射线晶体学，质谱，大规模蛋白质生产和化学合成的NMR光谱中的核心设施。该中心的五个研究核心设施具有高度互动性，从而使研究人员可以通过所有阶段开发一个项目，从识别特定的生物医学意义的特定蛋白质，确定这些蛋白质的结构以及它们如何与其他蛋白质和代谢物相互作用，在某些情况下，在某些情况下设计药物到与蛋白质变化功能相关的治疗疾病相关的疾病。在接下来的五年中，我们的山毛中心的第三阶段战略计划是（1）是（1）维护和加强在I和II阶段开发的最先进的柯布雷研究核心设施，这对于支持中心的研究项目至关重要，并且（2）支持研究试验项目和培训组件，以维持蛋白质结构和蛋白质结构和蛋白质结构和protein protein结构和培训环境。我们的毛绒中心支持的所有研究项目旨在获得对蛋白质的结构和功能的详细分子水平的理解，这可能会改善对人类疾病的治疗。例如，一个项目的目的是开发和测试融合的甲状旁腺激素 - 胶原蛋白结构蛋白用于治疗骨质疏松症。