Longitudinal study of exposure to PBDEs and PFCs and child neurobehavior

PBDEs 和 PFCs 暴露与儿童神经行为的纵向研究

• 批准号: 8462975
• 负责人: Aimin Chen
• 金额: $ 56.44万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-23 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8462975
• 关键词: 3 year old; 5 year old; 8 year old; Acids; Address; Adverse effects; Age; Animals; Attention; Behavior; Biological; Birth; Blood; Brain; Chemical Exposure; Chemicals; Child; Clinical; Cognition; Cohort Studies; Data; Development; Dose; Dust; Environment; Environmental Exposure; Environmental Health; Epidemiologic Studies; Exhibits; Exposure to; Family; Flame Retardants; Funding; Future; Goals; Health; Hormonal; House Dust; Human; Human Milk; Hyperactive behavior; Impaired cognition; Impairment; Individual; Infant; Learning; Longitudinal Studies; Maternal Exposure; Measures; Memory; Mission; Motor Skills; National Institute of Environmental Health Sciences; Neurotoxins; Oral cavity; Organic Chemicals; Outcome Measure; Phase; Placenta; Predisposition; Pregnancy; Pregnant Women; Prevention; Prospective Studies; Recruitment Activity; Regulation; Reporting; Research; Research Personnel; Research Project Grants; Risk; Role; Route; Sampling; Scientist; Serum; Staging; Sulfonic Acids; Testing; Thyroid Function Tests; Thyroid Hormones; Time; Toxic Environmental Substances; Toxic effect; United States National Institutes of Health; Visit; Woman; base; cognitive function; cohort; consumer product; design; developmental neurotoxicity; executive function; experience; fetal; follow-up; high risk; human study; in utero; maternal serum; neurobehavior; neurobehavioral; neurodevelopment; novel; perfluorooctane; phenyl ether; pollutant; postnatal; prenatal; response; sample collection; surfactant

DESCRIPTION (provided by applicant): Polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl chemicals (PFCs, including perfluorooctane sulfonic acid [PFOS] and perfluorooctanoic acid [PFOA]) are persistent organic chemicals that were introduced several decades ago. Animal studies and limited human studies of PBDEs and PFCs have found evidence for developmental neurotoxicity in children, including thyroid hormone disruption, hyperactivity, delay in neuromotor maturation, and impaired cognition. Although these chemicals are being phased out, humans will still be exposed to PBDEs and PFCs in the environment for decades because these compounds were widely used as flame retardants and surfactants in consumer products. To address the potential adverse health risks of PBDEs and PFCs on fetal, infant, and child neurobehavioral development, the investigators will systematically examine their associations with thyroid function, cognition, learning and memory, motor skills, attention and executive function, and behavior from age 1 to 8 years. The long-term goal is to quantify the roles of PBDE and PFC exposures on child neurobehavior and to inform future prevention efforts. The three specific aims are to: 1) investigate the associations between prenatal and postnatal exposures to PBDEs and thyroid hormones and child neurobehavior; 2) examine the associations between prenatal and postnatal exposures to PFCs and thyroid hormones and child neurobehavior; and 3) assess the environmental exposure to PBDEs through transplacental and lactational routes and indoor dust in children. The investigators will test these associations in the Health Outcomes and Measures of the Environment (HOME) Study, an ongoing NIEHS-funded longitudinal birth cohort of 398 women and their children with current follow-up to 5 years. The investigators will extend the cohort to include an age 8 follow-up clinical visit with comprehensive neurobehavior assessments. The investigators will examine the PBDE and PFC exposures at different developmental stages (in utero at 16 weeks of gestation, ages 3, 5, and 8 years) and child neurobehavior measured at 1, 2, 3, 4, 5, and 8 years using stored serum samples. This longitudinal study will allow the investigators to determine the dose response, windows of susceptibility, and persistence of the association. We will also examine the contribution of PBDE exposures from house dust in a subset of children who have complete sample collection of maternal serum and child serum at 1, 2, and 3 years, along with extensive measures of mouthing behaviors. This research is closely related to the NIH mission to investigate prevalent environmental toxicants and children's neurodevelopment.

描述（由申请人提供）：多溴二苯基醚（PBDES）和全氟烷基化学物质（包括全氟辛烷磺酸[PFOS] [PFOS]和全氟辛酸[PFOA]）是持续的有机化学物质，是几十年前引入的。动物研究和对PBDE和PFC的人类研究有限，发现儿童发育神经毒性的证据，包括甲状腺激素破坏，多动，神经运动的成熟度延迟和认知受损。尽管这些化学物质被淘汰，但数十年来，人类仍将暴露于环境中的PBDES和PFC，因为这些化合物在消费产品中被广泛用作阻燃剂和表面活性剂。为了解决PBDE和PFC对胎儿，婴儿和儿童神经行为发展的潜在不良健康风险，研究人员将系统地检查其与甲状腺功能，认知，学习能力，运动技能，注意力，注意力和执行功能以及1至8岁的行为的关联。长期目标是量化PBDE和PFC暴露于儿童神经行为的作用，并为未来的预防工作提供信息。这三个具体目的是：1）研究产前和产后暴露与PBDES和甲状腺激素与儿童神经行为的关联； 2）检查产前和产后暴露与PFC和甲状腺激素与儿童神经行为之间的关联； 3）通过移植和泌乳路线和儿童的室内灰尘评估环境暴露于PBDES。研究人员将在环境研究（家庭）研究的健康结果和措施中测试这些关联，这是一项由398名妇女及其儿童组成的NIEHS资助的纵向纵向出生队列，目前有5年的随访。研究人员将将队列扩展到包括8岁的随访临床访问，并进行全面的神经行为评估。研究人员将检查不同发育阶段的PBDE和PFC暴露（在妊娠16周的子宫内，年龄在3、5和8岁之间），使用储存的血清样品在1、2、3、4、5和8年测得的儿童神经行为。这项纵向研究将使研究人员能够确定剂量反应，易感性和关联的持久性。我们还将研究在1、2和3年以1、2和3年的完整样本收集孕产妇血清和儿童血清样本的子集中，PBDE暴露于房屋灰尘的贡献，以及广泛的介绍行为。这项研究与NIH调查普遍的环境有毒物质和儿童神经发育密切相关。