MUSC Center for Oral Health Research

MUSC 口腔健康研究中心

基本信息

批准号：
8540443
负责人：
Keith L Kirkwood
金额：
$ 102.13万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-05 至 2017-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8540443
关键词：
Accountability Achievement Affect Area Basic Science Biology Biomedical Engineering Centers of Research Excellence Chronic Disease Clinical Clinical Research Complement Core Facility Data Dental Dental Care Dental Schools Dental caries Diabetes Mellitus Dietary Practices Disease Environment Extramural Activities Faculty Fostering Funding Gnotobiotic Goals Grant Growth Growth and Development function Health Health Expenditures Herpes Labialis Human Resources Infectious Disease Immunology Institutes Institution Interdisciplinary Study Investigation Laboratories Laboratory Animal Production and Facilities Life Link Malignant Neoplasms Malignant neoplasm of pharynx Medicine Mentors Mouth Diseases National Institute of Dental and Craniofacial Research Oral Oral health Orofacial Pain Paper Peer Review Periodontal Diseases Phase Pilot Projects Positioning Attribute Publishing Recruitment Activity Regenerative Medicine Research Research Infrastructure Research Personnel Research Project Grants Research Training Resources Risk Factors Schools Services South Carolina Spottings Strategic Planning Therapeutic Intervention Tissues Tobacco use Training Programs Translational Research United States United States National Institutes of Health Universities abstracting anticancer research base college community based participatory research craniofacial health disparity laser capture microdissection malignant mouth neoplasm member new technology oral infection programs research facility success trend

项目摘要

With Phase III COBRE support, the MUSC Center for Oral Health Research (COHR) will complete its transition to long-term sustainability as a nationally competitive multidisciplinary research program in oral health. The COHR was conceived to expand the critical mass of funded investigators at MUSC in oral and craniofacial research and to enhance scientific core resources that serve as platforms to increase the capacity of our faculty to compete successfully for NIH funding. The COHR has mentored a total of 28 junior investigators to date, of which 17 have been promoted and 3 have earned tenure; 23 of the 28 have been retained at our institution. As a group, they have published more than 250 peer-reviewed papers and abstracts. They have received support from a total of 50 extramural grants, including 24 NIH grants on which they serve as PI or Key Personnel. The major components of this proposal are: A) The Administrative Core providing organizational, coordinating, fiscal and accountability functions; B) The Laboratory Core (L-COHR) providing services through four interactive facilities--the Gnotobiotic Animal Research Facility, Mineralized Tissue Facility, Oral Cancer Research Facility, and Laser Capture Microdissection Facility; C) The Clinical Core (C-COHR) fostering clinical and translational research and stimulating research discoveries through community-based participatory research; and D) The Pilot Project and Feasibility Projects Program providing support for pilot studies to foster research projects that utilize Center resources, personnel and facilities and facilitate interaction with COHR members. The COHR also has an NIH-funded research training component (T-COHR) that complements this proposal. The COHR's growth and activities have fueled a major cultural shift in the College of Dental Medicine and fostered recognition for oral health research at both campus and national levels. Research discoveries and grant success have created an interactive, supportive environment for research in the College of Dental Medicine. Thus, the Center for Oral Health Research is strategically positioned for long-term success as a critical resource for investigators developing new technologies, therapeutics and interventions to enhance the oral health of people in South Carolina and the United States.

借助III阶段的COBRE支持，MUSC口腔健康研究中心（COHR）将完成其向长期可持续性的过渡，因为它是一项具有全国竞争性的多学科研究计划。人们构思了COHR扩大口头和颅面研究中MUSC资助的研究人员的关键质量，并增强科学核心资源，这些核心资源是提高我们教职员工成功竞争NIH资金的能力的平台。迄今为止，COHR总共指导了28名初级调查人员，其中17名已被提升，其中3个赢得了任期。 28个中的23个已保留在我们的机构中。作为一个小组，他们发表了250多个经过同行评审的论文和摘要。他们总共获得了50个卫生赠款的支持，其中包括24个NIH赠款，他们是PI或关键人员。该提案的主要组成部分是：a）行政核心提供组织，协调，财政和问责制； b）实验室核心（L-COHR）通过四个互动设施提供服务 - gnotobirotic动物研究设施，矿化组织设施，口腔癌研究设施和激光捕获显微解剖设施； c）临床核心（C-COHR）通过基于社区的参与研究来促进临床和转化研究并刺激研究发现； d）试点项目和可行性项目计划为试点研究提供支持，以促进利用中心资源，人员和设施的研究项目，并促进与COHR成员的互动。 COHR还拥有NIH资助的研究培训组件（T-COHR），可补充该提案。 COHR的成长和活动助长了牙科医学院的重大文化转变，并在校园和国家一级培养了对口腔健康研究的认可。研究发现和赠款成功为牙科医学学院的研究创造了一个互动，支持性的环境。因此，在战略上将口腔健康研究中心的长期成功定位为开发新技术，治疗学和干预措施以增强南卡罗来纳州和美国人们口腔健康的关键资源。