TODAY STUDY GROUP GENETICS PROTOCOL

今日研究组遗传学方案

• 批准号: 8166747
• 负责人: Siripoom V McKay
• 金额: $ 0.8万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166747
• 关键词: Age; Blood; C-Peptide; Candidate Disease Gene; Cardiovascular system; Clinical; Collection; Communities; Comorbidity; Complications of Diabetes Mellitus; Computer Retrieval of Information on Scientific Projects Database; DNA; DNA Fingerprinting; Data; Development; Diabetes Mellitus; Diagnosis; Diagnostic tests; Dyslipidemias; Family history of; Funding; Genetic; Genetic Materials; Glucose; Grant; Hypertension; Informed Consent; Institution; Insulin Resistance; Measures; Medical History; Myocardial Infarction; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Participant; Prevention; Protocols documentation; Request for Proposals; Research; Research Personnel; Resources; Source; Stroke; Targeted Research; United States National Institutes of Health; novel diagnostics; prevent; repository

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The TODAY study group has prepared a protocol with the primary objective of collecting blood and phenotypic information to be used to explore relationships between candidate genes and type 2 diabetes (T2D), as well as obesity, insulin resistance, and cardiovascular complications of insulin resistance. Participation in the genetics study includes a blood draw for analysis of diabetes type and DNA extraction, as well as collection of basic family and medical history. Appropriate informed consent and assent are obtained from all participants to extract DNA and send blood, genetic material, and medical history to the Central Repository of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH). The data are kept indefinitely by the Central Repository. The NIDDK will issue requests for proposals (RFP) throughout the scientific community for research that may help in the development of new diagnostic tests, new treatments, and new ways to prevent diabetes and other related comorbidities. This is a repository for DNA and clinical information. Investigators wishing to access the repository would submit proposals to the TODAY Genetics group. NIDDK plans to issue an RFA to solicit proposals that would target research leading to improvements in the treatment and prevention of diabetes and related complications. A. Create a repository with DNA and clinical information for about 2,500 people diagnosed with type 2 diabetes before the age of 18. This repository will contain the following: a. Subject''s demographic information and medical history b. Family history of diabetes and complications of diabetes, hypertension, dyslipidemia, strokes and heart attacks. c. Random glucose and concurrent C-peptide will be measured and DNA will be collected.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 TODAY 研究小组制定了一项方案，其主要目标是收集血液和表型信息，用于探索候选基因与 2 型糖尿病 (T2D) 以及肥胖、胰岛素抵抗和胰岛素抵抗的心血管并发症之间的关系。 参与遗传学研究包括抽血分析糖尿病类型和 DNA 提取，以及收集基本家族史和病史。 获得所有参与者的适当知情同意和同意，提取 DNA 并将血液、遗传物质和病史发送至美国国立卫生研究院 (NIH) 国家糖尿病、消化和肾脏疾病研究所 (NIDDK) 中央存储库。 数据由中央存储库无限期保存。 NIDDK 将向整个科学界发布研究征求建议书 (RFP)，这些研究可能有助于开发新的诊断测试、新的治疗方法以及预防糖尿病和其他相关合并症的新方法。 这是 DNA 和临床信息的存储库。 希望访问该存储库的研究人员将向今日遗传学小组提交提案。 NIDDK 计划发布 RFA 来征求提案，这些提案的目标是改善糖尿病及相关并发症的治疗和预防的研究。 A. 为大约 2,500 名 18 岁之前诊断出患有 2 型糖尿病的人创建一个包含 DNA 和临床信息的存储库。该存储库将包含以下内容： 一个。 受试者的人口统计信息和病史 b. 糖尿病家族史以及糖尿病并发症、高血压、血脂异常、中风和心脏病。 c. 将测量随机葡萄糖和同时的 C 肽并收集 DNA。