CHOLESTEROL EFFLUX FROM MACROPHAGES

巨噬细胞中的胆固醇流出

• 批准号: 8166529
• 负责人: SHOBHA GHOSH
• 金额: $ 0.03万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166529
• 关键词: Arterial Fatty Streak; Atherosclerosis; Attenuated; Blood Vessels; Cholesterol; Cholesterol Esters; Computer Retrieval of Information on Scientific Projects Database; Foam Cells; Funding; Grant; High Density Lipoproteins; Hydrolysis; Institution; Patients; Pilot Projects; Research; Research Personnel; Research Proposals; Resources; Risk; Serum; Source; United States National Institutes of Health; macrophage; monocyte; particle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothesis of the study: Attenuated hydrolysis of stored cholesterol esters in atherosclerotic-lesion associated foam cells contributes to decreased cholesterol efflux capacity of serum HDL particles in patients with atherosclerosis or risk for atherosclerosis and is associated with decreased vascular endothelial function. The present research proposal aims to assess cholesterol efflux potential of serum, and its relationship to ApoAI / ApoAII ratio of HDL particles, monocyte/macrophage CEH expression and vascular endothelial function. This will be a cross-sectional pilot study investigating cholesterol efflux potential, ApoAI / ApoAII ratio, cholesterol ester hydrolysis expression, and endothelial function in three groups.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 研究假设：动脉粥样硬化病变相关泡沫细胞中储存的胆固醇酯的水解减弱，导致动脉粥样硬化或有动脉粥样硬化风险的患者血清高密度脂蛋白颗粒的胆固醇流出能力降低，并与血管内皮功能下降有关。 本研究旨在评估血清胆固醇流出潜力，及其与HDL颗粒ApoAI/ApoAII比值、单核细胞/巨噬细胞CEH表达和血管内皮功能的关系。 这将是一项横断面试点研究，调查三组的胆固醇流出潜力、ApoAI / ApoAII 比率、胆固醇酯水解表达和内皮功能。