EFFECTS BRANCHED CHAIN AMINO ACIDS & CAMOSINE PRECURSORS ON MUSCLE DAMAGE

影响支链氨基酸

• 批准号: 8166985
• 负责人: NAOMI K FUKAGAWA
• 金额: $ 0.17万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166985
• 关键词: Alanine; Antioxidants; Branched-Chain Amino Acids; Buffers; Carnosine; Computer Retrieval of Information on Scientific Projects Database; Data; Effectiveness; Exercise; Exercise Tolerance; Fatigue; Funding; Future; Grant; Histidine; Injury; Institution; Isoleucine; Leucine; Longevity; Maintenance; Muscle; Muscle Fatigue; Nerve Tissue; Older Population; Oxidative Stress; Performance; Personal Satisfaction; Population; Property; Proteins; Recommendation; Regimen; Research; Research Personnel; Resources; Role; Skeletal Muscle; Source; Supplementation; Time; United States National Institutes of Health; Valine; Work; attenuation; dietary supplements; improved; repaired

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A majority of the population believes in the benefits of nutritional supplements and takes them regularly. Understanding how different components of supplements interact and the mechanisms of their effects are vital for rational use and recommendations. The branched chain amino acids (BCAA) include leucine, isoleucine and valine and are unique in their effects on skeletal muscle and frequently used to reduce delayed onset muscle soreness and muscle fatigue after exercise. The objective of this work will be to determine whether BCAA and histidine (HIS) or B-alanine (B-ALA), which are precursors for camosine (CAR) synthesis, interact to enhance exercise performance. Carnosine is a dipetide composed of B-ALA and HIS and abundant in muscle and nervous tissue. We hypothesize that the addition of HIS or B-ALA to the BCAA regimen increases CAR levels, which in turn enhances the effectiveness of BCAA because of the CAR's antioxidant and buffering properties. A four-week supplementation period will be used to determine whether complementary effects exist between BCAA and HIS or B-ALA, leading to improved endurance (longer time to fatigue) and attenuation of muscle injury after prolonged low intensity exercise. This would support the concept that exercise performance may be enhanced by a combination of AA supplements. The mechanisms to be examined include the role of oxidative stress and the effect of the supplements on factors related to muscle synthesis and repair. This is of significance for athletes who want to enhance exercise performance and tolerance. Furthermore, the data will lay the groundwork for future studies in the older population for whom exercise tolerance and maintenance of body protein mass are essential to longevity and well-being.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 大多数人相信营养补充剂的好处并定期服用。 了解补充剂的不同成分如何相互作用及其作用机制对于合理使用和建议至关重要。 支链氨基酸 (BCAA) 包括亮氨酸、异亮氨酸和缬氨酸，对骨骼肌的作用独特，经常用于减少运动后迟发性肌肉酸痛和肌肉疲劳。 这项工作的目的是确定支链氨基酸 (BCAA) 和组氨酸 (HIS) 或 B-丙氨酸 (B-ALA)（作为肌氨肽 (CAR) 合成的前体）是否相互作用，从而提高运动表现。 肌肽是由 B-ALA 和 HIS 组成的二肽，在肌肉和神经组织中含量丰富。 我们假设在 BCAA 方案中添加 HIS 或 B-ALA 会增加 CAR 水平，由于 CAR 的抗氧化和缓冲特性，这反过来又会增强 BCAA 的有效性。 为期四个星期的补充期将用于确定 BCAA 与 HIS 或 B-ALA 之间是否存在互补作用，从而提高耐力（更长的疲劳时间）并减轻长时间低强度运动后的肌肉损伤。 这支持了这样的观点：结合使用 AA 补充剂可以提高运动表现。 要检查的机制包括氧化应激的作用以及补充剂对肌肉合成和修复相关因素的影响。 这对于想要增强运动表现和耐力的运动员来说具有重要意义。 此外，这些数据将为未来针对老年人群的研究奠定基础，对老年人群来说，运动耐力和维持体内蛋白质质量对于长寿和健康至关重要。