Microbiomes in Human Pancreatic Cancer
人类胰腺癌中的微生物组
基本信息
- 批准号:8582772
- 负责人:
- 金额:$ 71.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-07-19 至 2016-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): In the US, pancreatic cancer is the fourth leading cause of cancer-related death and is responsible for over 37,000 annual deaths. Prognosis is poor because most pancreatic cancers are diagnosed late in the progression of the disease, with only 5% of patients alive 5 years after initial diagnosis. Understanding the etiology of pancreatic cancer is critical to implement steps towards prevention and may concurrently provide insights on how to detect this highly fatal disease. Unfortunately, the causes of pancreatic cancer have been largely elusive and other than eliminating cigarette smoking and reducing obesity, opportunities for prevention are absent. Chronic pancreatitis and inflammation are thought to play a critical role in pancreatic carcinogenesis. Epidemiologic studies suggest that Helicobacter pylori infection and periodontal disease increase the risk of pancreatic cancer. We recently reported a 2-fold increase in risk of pancreatic cancer among individuals with high levels of antibodies to a pathogenic strain of Porphyromonas gingivalis (OR = 2.38, 95% CI =1.16-4.90, comparing >200 ng/ml vs. <200ng/ml). These findings underscore the need to perform a tissue based analysis to fully unveil the multifactorial microbial nature of pancreatic cancer. Thus, we propose to examine the human microbiota in pancreatic cancer patients, building from our expertise with the Human Microbiome Project. Our pilot study on pancreatic cancer tissue (fresh and paraffin-embedded) shows high levels of oral bacteria in all tissues tested thus far. For this proposal, we propose to (1) measure microbiota in patients with pancreatic cancer, and in subjects who did not have cancer using a combination of state-of-the-art molecular techniques; (2) examine possible routes of bacteria dissemination from the mouth to the pancreas. While this project will not be able to address causality directly, it will provide
valuable data to complement ongoing and future epidemiologic studies examining the role of bacteria in pancreatic cancer. This project is timely and highly relevant to the goals of the NIH Roadmap and the NIH Human Microbiome Project (HMP). Findings from this project will provide key data on the role of bacteria in pancreatic cancer and may provide new opportunities for prevention of this rapidly fatal disease, or for the development of early-stage detection biomarkers.
描述(由申请人提供):在美国,胰腺癌是与癌症有关的死亡的第四个主要原因,并导致年龄超过37,000人死亡。预后很差,因为大多数胰腺癌在疾病的进展后期都被诊断出来,最初诊断5年后只有5%的患者还活着。了解胰腺癌的病因对于实施预防步骤至关重要,并且可以同时提供有关如何检测这种高度致命疾病的见解。不幸的是,胰腺癌的原因在很大程度上是难以捉摸的,除了消除吸烟和减少肥胖症之外,没有预防机会。慢性胰腺炎和炎症被认为在胰腺癌中起着至关重要的作用。流行病学研究表明,幽门螺杆菌感染和牙周疾病会增加胰腺癌的风险。我们最近报道了对卟啉虫致病性抗体较高抗体的个体的胰腺癌风险增加了2倍(OR = 2.38,95%CI = 1.16-4.90,比较> 200 ng/ml vs. <200ng/ml)。这些发现强调了进行基于组织的分析以完全揭示胰腺癌的多因素微生物性质。因此,我们建议检查胰腺癌患者的人类微生物群,这是根据人类微生物组项目的专业知识来建立的。我们对胰腺癌组织(新鲜和石蜡填充)的试点研究显示,迄今为止所有测试的组织中的口服细菌都很高。对于此提案,我们建议(1)测量胰腺癌患者的微生物群,以及使用最先进的分子技术组合患有癌症的受试者; (2)检查细菌从口腔传播到胰腺的可能路线。虽然该项目将无法直接解决因果关系,但它将提供
有价值的数据以补充正在进行的和未来的流行病学研究,以研究细菌在胰腺癌中的作用。该项目与NIH路线图和NIH人类微生物组项目(HMP)的目标及时且高度相关。该项目的发现将提供有关细菌在胰腺癌中作用的关键数据,并可能为预防这种快速致命疾病或发展早期检测生物标志物提供新的机会。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

暂无数据
数据更新时间:2024-06-01
JACQUES G. IZARD的其他基金
Microbiomes in Human Pancreatic Cancer
人类胰腺癌中的微生物组
- 批准号:87044388704438
- 财政年份:2013
- 资助金额:$ 71.31万$ 71.31万
- 项目类别:
Microbiomes in Human Pancreatic Cancer
人类胰腺癌中的微生物组
- 批准号:90197739019773
- 财政年份:2013
- 资助金额:$ 71.31万$ 71.31万
- 项目类别:
SEROLOGICAL MARKERS OF PERIODONTAL DISEASE AND PANCREATIC CANCER RISK
牙周疾病和胰腺癌风险的血清学标志物
- 批准号:80533528053352
- 财政年份:2010
- 资助金额:$ 71.31万$ 71.31万
- 项目类别:
SEROLOGICAL MARKERS OF PERIODONTAL DISEASE AND PANCREATIC CANCER RISK
牙周疾病和胰腺癌风险的血清学标志物
- 批准号:77900457790045
- 财政年份:2010
- 资助金额:$ 71.31万$ 71.31万
- 项目类别:
STRUCTURAL ANALYSIS OF PERIPLASMIC FLAGELLAR FILAMENT DYNAMICS OF
周质鞭毛丝动力学结构分析
- 批准号:79545707954570
- 财政年份:2009
- 资助金额:$ 71.31万$ 71.31万
- 项目类别:
STRUCTURAL ANALYSIS OF PERIPLASMIC FLAGELLAR FILAMENT DYNAMICS OF
周质鞭毛丝动力学结构分析
- 批准号:77216957721695
- 财政年份:2008
- 资助金额:$ 71.31万$ 71.31万
- 项目类别:
Treponema denticola cytoskeletal filaments and oral infection
齿垢密螺旋体细胞骨架丝与口腔感染
- 批准号:73913097391309
- 财政年份:2007
- 资助金额:$ 71.31万$ 71.31万
- 项目类别:
Treponema denticola cytoskeletal filaments and oral infection
齿垢密螺旋体细胞骨架丝与口腔感染
- 批准号:72530187253018
- 财政年份:2007
- 资助金额:$ 71.31万$ 71.31万
- 项目类别:
STRUCT ANALYSIS PERIPLASMIC FLAGELLAR FILAMENT DYNAM OF TREPONEMA: SYPHILIS & HI
梅毒螺旋体周质鞭毛丝动态的结构分析
- 批准号:75983437598343
- 财政年份:2007
- 资助金额:$ 71.31万$ 71.31万
- 项目类别:
STRUCTURAL ANALYSIS OF PERIPLASMIC FLAGELLAR FILAMENT DYNAMICS OF TREPONEMA: SYP
密螺旋体周质鞭毛丝动力学的结构分析:SYP
- 批准号:73572717357271
- 财政年份:2006
- 资助金额:$ 71.31万$ 71.31万
- 项目类别:
相似国自然基金
靶向KK-LC-1的乳腺癌抗体偶联药物研发及机制研究
- 批准号:82373063
- 批准年份:2023
- 资助金额:46 万元
- 项目类别:面上项目
IL-6和PD-1抗体联用对KRAS突变肺腺癌的治疗作用及机制研究
- 批准号:82303747
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
抗体修饰的靶向型MOF材料的构建及其诱导HER2阳性乳腺癌铜死亡协同效应的研究
- 批准号:52371256
- 批准年份:2023
- 资助金额:51 万元
- 项目类别:面上项目
逆转乳腺癌多维度免疫抑制的正反馈增强型抗体偶联纳米药物
- 批准号:32371394
- 批准年份:2023
- 资助金额:50 万元
- 项目类别:面上项目
淋巴结结构重建在乳腺癌淋巴结转移灶响应PD-1抗体免疫治疗中的作用和机制
- 批准号:82373231
- 批准年份:2023
- 资助金额:49 万元
- 项目类别:面上项目
相似海外基金
CAR T cells targeting mesothelin and secreting bispecific antibodies targeting fibroblasts in pancreatic cancer
CAR T 细胞靶向间皮素并分泌靶向胰腺癌成纤维细胞的双特异性抗体
- 批准号:1073163510731635
- 财政年份:2023
- 资助金额:$ 71.31万$ 71.31万
- 项目类别:
Type 2 immunity: a primitive response to epithelial injury that shapes bone marrow and lung myeloid crosstalk
2型免疫:对上皮损伤的原始反应,形成骨髓和肺髓细胞串扰
- 批准号:1057795010577950
- 财政年份:2023
- 资助金额:$ 71.31万$ 71.31万
- 项目类别:
Development of contrast agents to facilitate image-guided surgery
开发造影剂以促进图像引导手术
- 批准号:1081018410810184
- 财政年份:2023
- 资助金额:$ 71.31万$ 71.31万
- 项目类别:
Project 2: Mechanisms of Resistance to Neoantigen Vaccines in PDAC
项目2:PDAC新抗原疫苗耐药机制
- 批准号:1070857510708575
- 财政年份:2023
- 资助金额:$ 71.31万$ 71.31万
- 项目类别:
Combination of tumor targeted therapy with stroma modulating agent for PDAC
肿瘤靶向治疗与基质调节剂联合治疗 PDAC
- 批准号:1062992410629924
- 财政年份:2023
- 资助金额:$ 71.31万$ 71.31万
- 项目类别: