UCLA Older Americans Independence Center

加州大学洛杉矶分校美国老年人独立中心

基本信息

批准号：
8471218
负责人：
DAVID B. REUBEN
金额：
$ 58.93万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-15 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8471218
关键词：
ARHGEF5 gene Address Adoption Age Aging American Anemia Area Award Basic Science Behavioral Biological Assay Biology Caring Chronic Disease Clinical Clinical Research Collaborations Communities Consultations Cost Effectiveness Analysis Decision Making Demography Development Disease Elderly Ensure Environment Face Fatigue Fostering Foundations Funding Generations Goals HIV HIV Infections Health Health system Healthcare Healthcare Systems Hour Inflammation Inflammatory Information Dissemination Intervention K-Series Research Career Programs Laboratories Leadership Link Los Angeles Low income Measurement Mental Depression Minority Mission Modeling Older Population Operations Research Outcome Paper Persons Pilot Projects Population Population Research Prevention Preventive Reading Recruitment Activity Research Research Infrastructure Research Personnel Research Support Resources Risk Role Services Sleep Sleep Disorders Socioeconomic Status Testing Therapeutic TimeLine Training Translational Research Uninsured United States National Institutes of Health Vulnerable Populations Work base career development clinical practice data management design disability functional disability health disparity improved innovation interest meetings novel novel diagnostics prevent ranpirnase success successful intervention translational approach

项目摘要

DESCRIPTION (provided by applicant): The UCLA Claude Pepper Older Americans Independence Center (OAIC) is designed to promote research aimed at maintaining and restoring the independence of older persons. Through its theme of Preventing Disease and Disability in Vulnerable Populations: a Translational Approach, the UCLA OAlC's research extends across the full spectrum from Tl to T2 translational research. Within this theme, an important focus of the UCLA OAIC is on understanding the role of inflammation in disease and disability. To accomplish its goals, the UCLA OAIC has established 4 Research Cores (Recruitment and Retention, Research Operations, Analysis and Cost Effectiveness, and Inflammatory Biology) and a new Information Dissemination Core that will facilitate OAlC-related research at every step (recruitment, measurement, data management, analysis, interpretation, and adoption of findings). Research cores provide support at 4 levels: Consultation (e.g., providing up to several hours of advice, reading a paper or a proposal) Partnership on new proposals Short-term (e.g., up to 2-3 days of consultation, performing assays) Ongoing or long-term support (e.g., ongoing, part of the project team) In addition, the UCLA OAIC Pilot and Exploratory Studies Core and Research Career Development Core stimulate new research via a pipeline of junior investigators and pilot awards and recruit successful investigators into OAlC-related research. The Leadership/Administrative Core ensures that these specific activities are accomplished and the goals of the UCLA OAIC are optimally achieved. The UCLA OAIC will address health disparities that vulnerable older persons face because of 1) inadequate understanding of contributors (e.g., socioeconomic status, inflammation) to health and specific illnesses (e.g., HIV, sleep, depression), 2) lack of effective preventive or therapeutc approaches (biomedical and behavioral), or 3) inadequate ability to get needed treatment to vulnerable older populations (e.g., cultural barriers, ineffective health care systems). By focusin efforts and resources through the OAIC, the timeline for research to develop, test, and disseminate promising innovations to maintain independence can be accelerated.

描述（由申请人提供）：UCLA Claude Pepper老年美国人独立中心（OAIC）旨在促进旨在维持和恢复老年人独立性的研究。 UCLA OALC的研究通过其预防疾病和残疾的主题：一种转化方法，从TL到T2转化研究。在此主题中，UCLA OAIC的一个重要重点是了解炎症在疾病和残疾中的作用。为了实现其目标，UCLA OAIC已建立了4个研究核心（招聘和保留，研究操作，分析和成本效益以及炎症生物学），以及一个新的信息传播核心，这些核心将促进OALC相关的研究（招聘，测量，数据管理，分析，解释，解释，解释，解释，解释和采用））。研究核心提供4个级别的支持：咨询（例如，提供多达几个小时的建议，阅读论文或提案）新建议的合作伙伴关系短期（例如，最多2-3天的咨询，进行测定）正在进行的或长期的支持（例如，正在进行的项目团队的一部分）此外，加州大学洛杉矶分校OAIC的飞行员和探索性研究核心和研究职业发展核心通过初级调查人员和试点奖的管道刺激了新的研究，并招募了成功的研究人员参加与OALC相关的研究。领导/行政核心确保完成这些特定活动，并最佳地实现UCLA OAIC的目标。 The UCLA OAIC will address health disparities that vulnerable older persons face because of 1) inadequate understanding of contributors (e.g., socioeconomic status, inflammation) to health and specific illnesses (e.g., HIV, sleep, depression), 2) lack of effective preventive or therapeutc approaches (biomedical and behavioral), or 3) inadequate ability to get needed treatment to vulnerable older populations (e.g.,文化障碍，无效的医疗保健系统）。通过通过OAIC的重点努力和资源，可以加速发展，测试和传播有希望的创新以保持独立性的时间表。