Multidimensional pathways to healthy aging among Filipino women

菲律宾女性健康老龄化的多维途径

基本信息

批准号：
8494505
负责人：
Linda S Adair
金额：
$ 48.97万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8494505
关键词：
Activities of Daily Living Adult Affect Age Age-Years Aging Air Biological Biological Markers Blood Pressure Body Composition Cardiovascular Diseases Caregivers Caring Characteristics Child Chronic Disease Cognition Cognitive Cohort Studies Communities Country Crowding Data Development Diet Dimensions Disease Dyslipidemias Early treatment Economic Development Economics Education Elderly Environment Environmental Risk Factor Family Relationship Family dynamics Filipino Goals Growth Health Health Care Costs Health Policy Health Surveys Health Transition Healthcare Heterogeneity Household Housing Human Immune Immune response Impaired cognition Income Individual Inflammation Interdisciplinary Study Life Life Experience Life Style Long-Term Effects Longevity Maintenance Measures Mental Depression Mental Health Methods Modeling Morbidity - disease rate Mothers Nutrition Surveys Participant Pathway interactions Pattern Personal Satisfaction Philippines Physical Function Physical activity Physical environment Policies Population Pregnant Women Prevention Preventive Public Health Quality of life Research Resolution Risk Risk Factors Role Rural Community Sample Size Sanitation Shapes Social Change Socioeconomic Status Structure Surveys Techniques Testing Time Urbanization Vaccination Weight Woman Women&apos s Health Work age group age related base cohort density design disability disorder risk emerging adult experience family structure functional disability functional outcomes glucose metabolism grandparent healthy aging improved insight interest lifestyle factors longitudinal analysis metropolitan physical conditioning psychologic psychosocial response screening skills social

项目摘要

DESCRIPTION (provided by applicant): This interdisciplinary study aims to identify biological, social, economic, and environmental influences on trajectories of health and functional outcomes in women in the transitional years from middle to later adulthood. It seeks to identify early adulthood experiences and exposures that affect (1) physical health, including body composition; blood pressure, biomarkers of inflammation and immune response to vaccination, dysregulation of glucose metabolism, and dyslipidemia; (2) physical functioning and disability; (3) cognition; and (4) psychosocial aspects of well-being including quality of relationships and depression. Data come from the ongoing, community-based Cebu Longitudinal Health and Nutrition Survey (CLHNS). The CLHNS has followed women through multiple survey rounds since 1983. With the proposed two additional survey rounds, the data will span a 30-year period of adult life, with a sample size of about 1875. Participants live in Metro Cebu, Philippines, in a changing environment characterized by rapid urbanization, social change, and economic development, providing an ideal setting in which to study how such changes influence health and functional capacity over time. At present 54% of women are 50-60 and 18% are >60 years old. Initial analysis will identify the sequence of development and patterns of co-occurrence of morbidity and disability risk. Subsequent multilevel longitudinal analysis will model the time-varying effects of the physical environment, including urbanization and its components of sanitation, air quality, crowding, housing density; socioeconomic status represented by wealth, income and education; family structure and relations with a focus on grandparenting roles; multiple dimensions of work related to its physical and time demands as well as work roles related to status and autonomy; as well as diet quality and physical activity. These exposures were selected because of their substantive importance, strong policy significance, and availability of especially detailed, high quality longitudinal data from the CLHNS. The study has the important advantage of having baseline data collected prior to the development of aging-related disease and disability, and will be able to identify causal associations.

描述（由申请人提供）：这项跨学科研究旨在确定生物、社会、经济和环境对女性中年到成年后期过渡时期健康和功能结果轨迹的影响。它旨在确定影响 (1) 身体健康（包括身体成分）的成年早期经历和暴露；血压、炎症生物标志物和疫苗接种免疫反应、葡萄糖代谢失调和血脂异常； (2) 身体机能和残疾； (3)认知； (4) 幸福感的社会心理方面，包括人际关系质量和抑郁。数据来自正在进行的、以社区为基础的宿务纵向健康和营养调查（CLHNS）。自 1983 年以来，CLHNS 已通过多轮调查对女性进行跟踪。根据拟议的另外两轮调查，数据将跨越成人生活的 30 年，样本量约为 1875 人。参与者居住在菲律宾宿雾市，以快速城市化、社会变革和经济发展为特征的不断变化的环境，为研究这些变化如何随着时间的推移影响健康和功能能力提供了理想的环境。目前，54%的女性年龄在50-60岁之间，18%的女性年龄>60岁。初步分析将确定发病和残疾风险的发展顺序和同时发生的模式。随后的多层次纵向分析将模拟物理环境随时间变化的影响，包括城市化及其卫生、空气质量、拥挤、住房密度等组成部分；以财富、收入和教育为代表的社会经济地位；家庭结构和关系，重点关注祖父母角色；与身体和时间需求相关的工作的多个维度以及与地位和自主性相关的工作角色；以及饮食质量和身体活动。选择这些风险敞口是因为它们具有实质性重要性、强大的政策意义以及来自 CLHNS 的特别详细、高质量的纵向数据的可用性。该研究的重要优点是在与衰老相关的疾病和残疾发生之前收集基线数据，并且能够识别因果关系。