Midcareer Investigator Award

职业生涯中期研究员奖

• 批准号: 8531887
• 负责人: Stephen Jay Freedland
• 金额: $ 17.55万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-16 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8531887
• 关键词: Adverse effects; Affect; Aftercare; Androgens; Award; Biological Markers; Body Weight; Body Weight decreased; C-reactive protein; Cancer Biology; Cancer Patient; Carbohydrates; Clinical; Clinical Trials; Cohort Studies; Diet; Disease; Disease Progression; Exercise; Faculty; Fatty acid glycerol esters; Funding; Future; Generations; Goals; Growth; Human; In Vitro; Insulin; Intake; Intervention; Intervention Studies; Leptin; Life Style; Link; Malignant Neoplasms; Malignant neoplasm of prostate; Measures; Mediator of activation protein; Medical Oncology; Medical Students; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Morbidity - disease rate; Mus; Natural History; Obesity; Outcome; Patients; Phase; Pilot Projects; Pomegranate; Population; Process; Prostate Cancer therapy; Prostatic; Public Health; Radical Prostatectomy; Recurrence; Research; Research Personnel; Research Training; Risk; Role; Scientist; Serum; Source; Surgeon; Testing; Time; Toxic effect; Training; Urologist; Urology; Weight; adiponectin; arm; cancer therapy; career; clinical care; deprivation; diet and exercise; dietary restriction; dietary supplements; glycemic control; improved; insulin signaling; lifestyle intervention; meetings; men; next generation; oxidative damage; patient oriented research; prevent; primary outcome; programs; prospective; randomized trial; secondary outcome; trial comparing; tumor progression; urologic

DESCRIPTION (provided by applicant): This Midcareer Investigator Award application seeks support to provide Dr. Freedland with protected time for patient-oriented research (POR) and to act as research mentor for junior faculty and 1 research fellow per year. Dr. Freedland's POR focuses on retrospective cohort studies with a transitioning emphasis on prospective clinical trials aimed at developing new and less toxic treatments to minimize prostate cancer treatment side effects and slow prostate cancer progression. Herein, he proposes a new trial comparing a carbohydrate-restricted diet vs. control for men with PSA recurrence after prostate cancer therapy aiming to slow the rate of PSA rise (lengthen the PSA doubling time), as an indirect measure of slowed prostate cancer growth. Secondary outcomes include weight loss and important prostate cancer biomarkers. Successful completion of this award will advance our understanding of lifestyle and other low toxicity interventions for prostate cancer as well as help educate the next generation of POR investigators.

描述（由申请人提供）：该中级研究员奖申请申请寻求支持，以向弗里德兰博士提供受患者面向患者的研究（POR）的受保护时间，并担任初级教职员工的研究导师和每年1名研究员。 Freedland博士的POR专注于回顾性队列研究，其过渡强调前瞻性临床试验，旨在开发新的和毒性较小的治疗方法，以最大程度地减少前列腺癌治疗副作用和缓慢的前列腺癌的进展。在此，他提出了一项新的试验，比较了前列腺癌治疗后PSA复发的碳水化合物限制性饮食与对照，旨在减缓PSA升高的速度（延长PSA倍增时间），这是前列腺癌生长缓慢的间接度量。次要结果包括体重减轻和重要的前列腺癌生物标志物。成功完成该奖项将使我们对前列腺癌的生活​​方式和其他低毒性干预措施的了解以及帮助 教育下一代POR调查人员。