CLINICAL CORE C

临床核心C

• 批准号: 8147512
• 负责人: RICHARD J MARTIN
• 金额: $ 32.44万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8147512
• 关键词: Adrenal Cortex Hormones; Allergens; Antigens; Asthma; Biopsy; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Bronchoscopy with Bronchoalveolar Lavage; Cells; Characteristics; Clinical; Collection; Communication; Data; Databases; Development; Equipment and Supplies; Human Resources; Hypersensitivity skin testing; Individual; Irrigation; Laboratories; Liquid substance; Morphology; Patients; Performance; Procedures; Process; Program Research Project Grants; Pulmonary function tests; Quality Control; Recruitment Activity; Research Personnel; Resistance; Respiratory physiology; Steroids; Structure of parenchyma of lung; Tissues; Training; computerized; high standard; improved; methacholine; programs; pulmonary function

The objectives of the Clinical Core C are: 1. To provide a central laboratory for the recruitment and characterization of normal and asthmatic subjects for the clinical components of Projects 1, 2, and 3. 2. To provide a central facility for performance and quality control of pulmonary function testing, antigen skin testing, and methacholine challenge. 3. To provide a central laboratory for collection and analysis of bronchoalveolar lavage fluid and biopsy tissue. 4. To coordinate the distribution of bronchoalveolar lavage cells and fluid, and biopsy tissue to the investigators in Projects 1, 2, and 3. 5. To coordinate the database development of all clinical and laboratory data on normal subjects and patients with asthma as well as transmittal of the data to the individual investigators. 6. To facilitate interproject communication concerning both clinical findings and technical accomplishments. In doing so, the clinical aspects of this Program Project grant will function at a high standard.

临床核心 C 的目标是： 1. 为项目 1、2 和 3 的临床部分提供一个中心实验室，用于招募和表征正常和哮喘受试者。 2. 为肺功能测试、抗原皮肤测试和乙酰甲胆碱激发的性能和质量控制提供中央设施。 3. 提供支气管肺泡灌洗液和活检组织采集和分析的中心实验室。 4. 协调向项目 1、2 和 3 的研究人员分配支气管肺泡灌洗细胞和液体以及活检组织。 5. 协调正常受试者和哮喘患者的所有临床和实验室数据的数据库开发，以及将数据传输给个别研究者。 6. 促进有关临床发现和技术成果的项目间沟通。 在此过程中，该计划项目拨款的临床方面将按照高标准发挥作用。