Effect of tendon damage accumulation on healing and adaptation

肌腱损伤累积对愈合和适应的影响

• 批准号: 8535264
• 负责人: NELLY Andarawis-Puri
• 金额: $ 38.24万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8535264
• 关键词: Apoptosis; Apoptotic; Biological; Cells; Cellularity; Clinical; Disease; Environment; Exercise; Failure; Fatigue; Foundations; Goals; Healed; Homeostasis; Immobilization; Injury; Laceration; Length; Manuscripts; Matrix Metalloproteinases; Mechanics; Modeling; Moderate Exercise; Molecular; Musculoskeletal; Outcome; Preparation; Property; Protocols documentation; Publishing; Rattus; Recommendation; Resistance; Role; Rotator Cuff; Rupture; Simulate; Societies; Source; Tendon Injuries; Tendon structure; Testing; Up-Regulation; Weight-Bearing state; abstracting; base; clinically relevant; collagenase 3; disability; healing; improved; in vivo; in vivo Model; insight; novel; repaired; response; treatment strategy

DESCRIPTION (provided by applicant): Damage accumulation in tendons and tendon tears are a major source of musculoskeletal disability, afflicting the entire spectrum of society. Despite the importance of these problems, clinicians have little scientific basis for treatment recommendations because mechanisms whereby exercise may improve tendon homeostasis and resistance to injury, mechanisms responsible for the poor healing of fatigue damaged tendons, and the effect of activity on the healing of repaired diseased tendons are unknown. Previous studies have investigated the effects of exercise and laceration, but only in healthy tendon. We have developed and extensively characterized an in vivo model of fatigue damage accumulation in the rat patellar tendon, and now propose to study the response of fatigue damaged tendon to exercise and/or laceration. These studies, using this clinically relevant model of diseased tendons, will provide the foundation for novel and improved treatment strategies.

描述（由申请人提供）：肌腱和肌腱撕裂中的损害积累是肌肉骨骼残疾的主要来源，折磨了整个社会范围。尽管这些问题很重要，但临床医生对治疗建议的科学依据很少，因为运动可能会改善肌腱稳态和对伤害的抵抗力，导致疲劳性疲劳受损肌腱治愈不佳的机制以及活动对修复疾病肌腱治愈的影响。先前的研究研究了运动和裂伤的影响，但仅在健康肌腱中。我们已经开发并广泛地表征了大鼠tellar肌腱中疲劳损伤积累的体内模型，现在建议研究疲劳受损肌腱对运动和/或裂缝的响应。这些研究使用这种临床相关的患病肌腱模型，将为新颖和改进的治疗策略提供基础。