Mobility Life: Monitoring Mobility in Daily Lives of People with Neurological Disease

移动生活：监测神经系统疾病患者日常生活中的移动能力

• 批准号: 9523322
• 负责人: Mahmoud El-Gohary
• 金额: $ 88.63万
• 依托单位: APDM, INC.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9523322
• 关键词: Admission activity; Adult; Age; Algorithms; Ankle; Bandage; Businesses; Cessation of life; Clinic; Clinical; Clinical Research; Collaborations; Complex; Consensus; Databases; Disease Progression; Environment; Equilibrium; Fatigue; Gait; Goals; Grant; Health Sciences; Home environment; Hospitals; Human; Huntington Disease; Impairment; Injury; Laboratories; Length; Life; Measures; Medical; Mission; Monitor; Movement; Movement Disorders; Multiple Sclerosis; Neurologic; Neurologist; Neurology; Nursing Homes; Oregon; Parkinson Disease; Patient Monitoring; Patients; Performance; Pharmaceutical Preparations; Phase; Preparation; Quality of life; Reference Values; Reporting; Research Personnel; Severities; Shoes; Small Business Innovation Research Grant; Stress; System; Technology; Testing; Treatment Efficacy; Universities; Visiting Nurse; Wireless Technology; Work; age related; clinical practice; disability; experience; fall risk; falls; foot; improved; innovation; instrument; interest; intervention effect; light weight; mild cognitive impairment; nervous system disorder; novel; patient population; physical therapist; prospective; response; sensor; technology development; verification and validation; wearable technology

Project Summary Falls are the leading cause of injuries, hospital visits, nursing home admissions, and reduced quality of life for people with neurological disorders. Although there is consensus that impaired mobility is the basis for most falls, it is very difficult to evaluate these complex abilities outside a laboratory setting. Brief clinical examinations do not accurately reflect daily, functional mobility in real life environments. Patients at risk of falls would benefit from a system they can easily use to measure their daily mobility, assess mobility fluctuations throughout the day, evaluate their risk of falling, and measure effects of interventions aimed at improving their functional mobility and reducing their falls. No commercial technology yet exists to continuously monitor fluctuations in mobility or quantify fall risk in natural environments during normal activities. We developed and validated an unobtrusive system, called Mobility Life, to objectively characterize gait and turning during spontaneous activities with wearable inertial sensors. During this Phase II, we will develop an instrumented ankle wrap for continuous monitoring of gait, develop a user interface to support clinical research, develop reports that show indications of fall risk for clinical practice, and thoroughly verify and validate our technology. We will also determine which metrics are most indicative of fall risk and determine normative values for non-fallers in the same age range as the expected patient populations. Our specific aims are: AIM I. Technology Development: Prepare Mobility Life for clinical practice. · Milestone 1: Develop an instrumented elastic ankle bandage (SmartSox) for continuous gait monitoring. · Milestone 2: Develop useful clinical reports to convey patients' daily mobility impairments, fluctuations, and fall risk. · Milestone 3: Complete the system verification and validation in preparation for FDA 510(k) clearance to market. Aim II. Clinical Research: Demonstrate the clinical utility of Mobility Life to monitor quality of functional mobility and fall risk in neurological patients. · Milestone 4: Determine which daily life mobility impairments best predict fall risk in patients with PD or MS. · Milestone 5: Develop reference values for integrity of functional mobility in healthy age-matched subjects.

项目摘要 跌倒是受伤，医院探访，疗养院入院和减少生活质量的主要原因 神经系统疾病的动力。 很难评估这些复杂的临床缩减之外的复杂性。 在现实生活环境中，无法准确反映每天的功能流动性。 从一个系统中可以轻松地用于测量每日活动性，评估活动的流动性，这一天， 评估他们跌倒的风险，并测量旨在改善其功能流动性的干预措施的影响 并减少他们的瀑布。 在正常活动中量化自然环境中的跌落风险。 我们开发并验证了一个名为Mobility Life的不引人注目的系统，以客观地表征步态。 在具有可穿戴惯性传感器的自发活动中转动。 仪器踝关节包裹可连续监测步态，开发一个用户界面以支持临床研究， 开发报告表明表明临床实践风险的迹象，并彻底验证和验证我们 技术。 对于与预期的患者人群相同的年龄范围的非差异者。 AIM I.技术开发：为临床实践准备移动性生活。 ·里程碑1：开发一种仪器弹性踝绷带（SMARTSOX）进行连续步态监测。 ·里程碑2：制定有用的临床报告以使患者每日移动障碍降临 跌倒风险。 ·里程碑3：完成系统的验证和验证，以准备FDA 510（k）间隙 市场。 AIM II。 神经系统患者的功能活动性和跌倒风险。 ·里程碑4：确定哪些日常生活流动性障碍最好地预测PD患者的跌倒风险 多发性硬化症。 ·里程碑5：在健康年龄匹配的受试者中发展健康功能完整性的参考值。

项目成果

Laboratory versus daily life gait characteristics in patients with multiple sclerosis, Parkinson's disease, and matched controls.

• DOI: 10.1186/s12984-020-00781-4
• 发表时间: 2020-12-01
• 期刊: Journal of neuroengineering and rehabilitation
• 影响因子: 5.1
• 作者: Shah VV;McNames J;Mancini M;Carlson-Kuhta P;Spain RI;Nutt JG;El-Gohary M;Curtze C;Horak FB
• 通讯作者: Horak FB

Does gait bout definition influence the ability to discriminate gait quality between people with and without multiple sclerosis during daily life?

• DOI: 10.1016/j.gaitpost.2020.11.024
• 发表时间: 2021-03
• 期刊: Gait & posture
• 影响因子: 2.4
• 作者: Shah VV;McNames J;Harker G;Curtze C;Carlson-Kuhta P;Spain RI;El-Gohary M;Mancini M;Horak FB
• 通讯作者: Horak FB