Clinical Subject and Biospecimen Core

临床受试者和生物样本核心

基本信息

批准号：
8468301
负责人：
PRESCOTT G WOODRUFF
金额：
$ 37.46万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8468301
关键词：
Adrenal Cortex Hormones Affinity Allergens Allergic Antigens Asthma Biological Biological Assay Biological Markers Biopsy Breathing Bronchoscopy CD4 Positive T Lymphocytes Calcium Cell Communication Cells Clinical Clinical Research Collagen Collection Complex Data Development Disease Dyes Enrollment Ensure Epithelial Epithelium Event Flow Cytometry Gene Expression Helper-Inducer T-Lymphocyte Homing Hour Human IL17 gene Image Imagery Imaging technology Immune Immunohistochemistry In Situ Individual Inflammation Instruction Interleukin-13 Interleukin-17 Knowledge Label Lead Life Lung Lung diseases Lymphocyte Function Measurement Methods MicroRNAs Microscopy Modeling Molecular Mus Muscle Nature Pathogenesis Performance Phenotype Population Preparation Process Protocols documentation Reagent Recruitment Activity Regulation Reporter Research Resources Role Sampling Secure Severities Signal Transduction Site Smooth Muscle Specificity Specimen Structure of parenchyma of lung System T-Cell Receptor T-Lymphocyte T-Lymphocyte Subsets Tetanus Helper Peptide Time Tissues airway epithelium allergic airway disease asthmatic airway carina clinically significant cytokine eosinophil experience human subject imaging modality improved lung imaging molecular phenotype mouse model novel outcome forecast programs response second harmonic therapy outcome trafficking two-photon

项目摘要

PROJECT SUMMARY (See instructions): The Clinical Subject and Biospecimen Core will provide a core resource for the recruitment and characterization of human subjects, the completion of the clinical studies, the collection and processing of biospecimens from these subjects, and measurement of key molecular and cellular biomarkers that will be used in systematic phenotyping of ILl3- and IL-17 driven inflammation across the projects. Dr Prescott Woodruff (Associate director of the UCSF-Airway Clinical Research Center), along with a team consisting of a research coordinator, two technicians, and a programmer analyst, have considerable experience in all aspects of these systems. Using the resources of this highly experienced and well-resourced group, the core will have four aims: (i) To recruit and enroll asthmatic subjects for the allergen challenge protocol to support the proposed projects; (ii) To collect high quality biospecimens from this allergen challenge study and 2 other ongoing clinical studies using systems and methods which ensure compliance with federal and local regulations; (iii) To provide specialized processing, secure storage, and timely distribution ofthe human biospecimens collected from the clinical studies (iv) To establish standardized assessment of IL13- and IL-17 phenotype to subjects enrolled in the clinical studies through analysis of airway epithelial gene expression, immunohistochemistry and flow cytometry.

项目摘要（请参阅说明）：临床主题和生物传播核心将为招聘提供核心资源和人类受试者的表征，临床研究的完成，从这些受试者中收集和加工生物测量以及对关键分子和细胞生物标志物的测量，这些标志物将用于整个项目的ILL3-和IL-17驱动炎症的系统表型。 Prescott Woodruff博士（UCSF-Airway临床研究中心的副主任）以及由研究协调员，两名技术人员和一名程序员分析师组成的团队在这些系统的各个方面都有丰富的经验。利用这个经验丰富且资源丰富的小组的资源，核心将有四个目标：（i）招募和招募过敏原挑战方案的哮喘科目来支持拟议的项目；（ii）使用该系统和方法从这项过敏原挑战研究中收集高质量的生物测量和其他正在进行的临床研究，以确保遵守联邦和地方法规；（iii）提供从临床研究中收集的人类生物测量的专业加工，安全存储和及时分布（iv）通过分析气道上皮基因表达，免疫组织化学和流式细胞仪来建立对参加临床研究的受试者的IL13-和IL-17表型的标准化评估。