Protective behavioral strategies and mental health: Reducing alcohol-related risk

保护性行为策略和心理健康：减少酒精相关风险

• 批准号: 8150460
• 负责人: Joseph W. Labrie
• 金额: $ 16.34万
• 依托单位: LOYOLA MARYMOUNT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8150460
• 关键词: Alcohol consumption; Alcohols; Anxiety; Area; Automobile Driving; Baseline Surveys; Behavioral; Client; Cognitive; Computers; Counseling; Data; Distress; Event; Feedback; Female; Future; Health; Human Resources; Intervention; Mediating; Mediator of activation protein; Mental Depression; Mental Health; Participant; Play; Psyche structure; Publishing; Randomized; Reporting; Risk; Services; Severities; Students; Surveys; Target Populations; Training; Treatment Efficacy; Work; alcohol consequences; alcohol intervention; alcohol related consequences; alcohol related problem; alcohol risk reduction; base; binge drinking; brief intervention; college; coping; drinking; experience; heavy drinking students; high risk; high risk drinking; interest; meetings; peer; post intervention; psychological distress; public health relevance; reduced alcohol use; skills training; university student

DESCRIPTION (provided by applicant): Escalating rates of psychological distress among college students create a new and, as yet, understudied area of concern for college personnel interested in reducing alcohol-related problems. Not only do students with poorer mental health (anxiety, depression, greater levels of psychological distress in comparison to peers) drink at levels equivalent to other students, but when controlling for drinking, they experience significantly more alcohol-related negative consequences. However, few alcohol interventions have targeted this population despite that fact that efforts to uncover effective strategies to reduce risk among students with co-morbid mental health issues and high-risk drinking hold wide implications. Further, our preliminary cross-sectional work has found that among students spontaneously employing cognitive behavioral protective behavioral strategies (PBS; e.g., spacing out drinks, avoiding risky activities while drinking such as playing drinking games or driving) aimed at reducing drinking (compared to students not employing PBS), students with poorer mental health experienced significantly greater reductions in consequences than those with better mental health, even after control for drinking. While PBS skills training has been part of several multi-component brief interventions, there is no published data about its efficacy as a stand-alone intervention. Thus, the proposed study will evaluate the efficacy of a stand-alone PBS cognitive-behavioral skills training with personalized feedback (PBS-STPF) intervention at increasing PBS use and reducing risky drinking and negative consequences among students seeking services from a college counseling center. Participants will be 350 student-clients from a college counseling center (60% female) who have had at least one heavy episodic drinking event in the past month. They will be randomized to either the PBS-STPF intervention or health information control condition. Both conditions involve completing a baseline survey on a computer followed by a one-one-one 20- 25 minute discussion. The PBS-STF intervention utilizes a personal PBS feedback sheet to reinforce existing PBS use while suggesting other protective strategies that the participant may use in the future. Participants will also explore ways to implement these strategies in frequently encountered and high-risk situations and explore ways to overcome barriers to implementation. Following either the PBS intervention or control discussion, the participants will be assessed via online surveys twice (1-month and 6-months post-intervention). We will also evaluate whether PBS use mediates intervention efficacy and whether level of severity of psychological distress and coping motives for drinking moderate intervention efficacy. This project will provide valuable information on both the efficacy of a cognitive behavioral based PBS stand-alone intervention among students with poorer mental health and preliminary data on relationships between various levels of general and specific mental health, alcohol use, and negative alcohol-related consequences. PUBLIC HEALTH RELEVANCE: This study evaluates the efficacy of a protective behavioral strategies (PBS) cognitive-behavioral skills training with personalized feedback (PBS-STPF) intervention aimed at increasing PBS use and reducing risky drinking and negative consequences among students seeking services from a college counseling center.

描述（由申请人提供）：大学生心理困扰的发生率不断上升，为有兴趣减少酒精相关问题的大学人员带来了一个新的、尚未得到充分研究的关注领域。心理健康状况较差（与同龄人相比焦虑、抑郁、心理困扰程度更高）的学生不仅饮酒水平与其他学生相当，而且在控制饮酒时，他们会经历更多与酒精相关的负面后果。然而，尽管发现有效策略来降低患有共病心理健康问题和高风险饮酒的学生的风险具有广泛的影响，但很少有酒精干预措施针对这一人群。此外，我们的初步横断面工作发现，学生自发地采用认知行为保护行为策略（PBS；例如，间隔饮酒、避免饮酒时进行危险活动，例如玩饮酒游戏或驾驶），旨在减少饮酒（与学生相比）不使用 PBS），即使在控制饮酒之后，心理健康状况较差的学生比心理健康状况较好的学生所遭受的后果显着减少。虽然 PBS 技能培训已成为多项多成分简短干预措施的一部分，但尚未公布有关其作为独立干预措施的有效性的数据。因此，拟议的研究将评估独立的 PBS 认知行为技能培训与个性化反馈 (PBS-STPF) 干预的效果，以增加 PBS 的使用并减少寻求大学咨询中心服务的学生的危险饮酒和负面后果。参与者将是来自大学咨询中心的 350 名学生客户（60% 为女性），他们在过去一个月中至少有过一次严重的偶发性饮酒事件。他们将被随机分配到 PBS-STPF 干预或健康信息控制条件。这两种情况都涉及在计算机上完成基线调查，然后进行 20-25 分钟的一对一讨论。 PBS-STF 干预利用个人 PBS 反馈表来强化现有的 PBS 使用，同时建议参与者将来可能使用的其他保护策略。参与者还将探讨在经常遇到的高风险情况下实施这些策略的方法，并探索克服实施障碍的方法。在 PBS 干预或对照讨论之后，参与者将通过两次在线调查进行评估（干预后 1 个月和 6 个月）。我们还将评估 PBS 的使用是否介导干预效果，以及心理困扰的严重程度和饮酒的应对动机是否调节干预效果。该项目将提供关于基于认知行为的 PBS 独立干预对心理健康状况较差的学生的有效性的有价值的信息，以及关于不同水平的一般和特定心理健康、饮酒和与酒精相关的负面后果之间关系的初步数据。 。 公共健康相关性：本研究评估了保护性行为策略 (PBS) 认知行为技能培训与个性化反馈 (PBS-STPF) 干预措施的有效性，旨在增加 PBS 的使用并减少寻求大学服务的学生的危险饮酒和负面后果咨询中心。

项目成果

Motif-Based Text Mining of Microbial Metagenome Redundancy Profiling Data for Disease Classification.

用于疾病分类的微生物宏基因组冗余分析数据的基于基序的文本挖掘。

• 发表时间: 2016
• 作者: Wang, Yin;Li, Rudong;Zhou, Yuhua;Ling, Zongxin;Guo, Xiaokui;Xie, Lu;Liu, Lei
• 通讯作者: Liu, Lei

Autoimmune hematological diseases following haploidentical donor hematopoietic stem cell Transplant compared with matched sibling and unrelated donor.

与匹配的兄弟姐妹和无关供者相比，单倍体相合供者造血干细胞移植后的自身免疫性血液疾病。

• 发表时间: 2017-04-18
• 作者: Lv, Weiran;Fan, Zhiping;Huang, Fen;Xu, Na;Xuan, Li;GuopanYu;Jiang, Qianli;Zhou, Hongsheng;Lin, Ren;Zhang, Xin;Sun, Jing;Liu, Qifa
• 通讯作者: Liu, Qifa

Comprehensive analysis of differential co-expression patterns reveal transcriptional dysregulation mechanism and identify novel prognostic lncRNAs in esophageal squamous cell carcinoma.

差异共表达模式的综合分析揭示了食管鳞状细胞癌中的转录失调机制并鉴定了新的预后lncRNA。

• 发表时间: 2017
• 作者: Li, Zhen;Yao, Qianlan;Zhao, Songjian;Wang, Yin;Li, Yixue;Wang, Zhen
• 通讯作者: Wang, Zhen

CD4+T Cell Subset Profiling in Biliary Atresia Reveals ICOS- Regulatory T Cells as a Favorable Prognostic Factor.

胆道闭锁中的 CD4 T 细胞亚群分析表明 ICOS 调节性 T 细胞是有利的预后因素。

• 发表时间: 2019
• 作者: Zhang, Shuhao;Goswami, Shyamal;Ma, Jiaqiang;Meng, Lu;Wang, Youping;Zhu, Fangming;Zhang, Dandan;Zheng, Shan;Dong, Rui;Xiao, Xianmin;Zhang, Xiaoming;Chen, Gong
• 通讯作者: Chen, Gong

Changes in plasma bile acids are associated with gallbladder stones and polyps.

血浆胆汁酸的变化与胆囊结石和息肉有关。

• 发表时间: 2020-10-31
• 影响因子: 2.4
• 作者: Wu, Linshi;Wang, Yinping;Zhu, Sibo;Bao, Xunxia;Fu, Zhiliang;Zhen, Timing;Yuan, Zhiqing;Li, Qiwei;Deng, Zheng;Sun, Jianhua;Chen, Tao
• 通讯作者: Chen, Tao