UAB Center for AIDS Research

阿拉巴马大学艾滋病研究中心

• 批准号: 8110793
• 负责人: Michael S. Saag
• 金额: $ 61.46万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8110793
• 关键词: UAB; Center; AIDS; Research

The mission of the UAB CFAR is to stimulate and support multidisciplinary basic, behavioral, clinical and translational AIDS research so as to hasten the development of effective treatments and prevention strategies for AIDS. For 20 years, the Center has played a vital role in supporting cutting edge research activities of its members that have led to paradigm-shifting discoveries, including: the discovery of HIV-1 quasispecies diversity (Nature 1988), detection of HIV-1 RNA in plasma (Science 1993), viral dynamics in acute and chronic infection (NEJM 1991; Nature 1995), HIV-1 escape from cytotoxic T-cells (Nat Medicine 1997) and neutralizing antibodies (Nature 2003), first-in-human phase 1 clinical studies of 7 currently approved therapies (NEJM 1993; Nat Medicine 1998; JAMA 2006), the zoonotic origins of HIV-1 (Nature 1999; Nature 2006; Science 2006), and the identification of the transmitted HIV-1 envelope and complete genome/proteome responsible for HIV infection (PNAS 2008). A common thread connecting all of these discoveries is the proactive participation of the CFAR in facilitating basic, translational and clinical research through effective collaboration between basic and clinical investigators. The objectives of the CFAR reflect this continuing commitment to innovative, multidisciplinary AIDS research and include: 1. To provide a central institutional focus for HIV/AIDS research activities that emphasize effective communication and collaboration among CFAR members and the wider HIV/AIDS research community. 2. To enhance productivity of ongoing research programs by encouraging interdisciplinary research and by providing critical shared resource facilities and administrative and fiscal management support to Center investigators. 3. To use robust strategic planning methods to identify new research opportunities and priorities, to align them with existing CFAR programs, and to foster new research programs where none are in existence but where faculty interest and University capacity is evident. 4. To stimulate the entry of junior and established faculty into HIV/AIDS research programs. This is accomplished through mentoring young investigators and by a peer-reviewed Developmental Grants Program. 5. To stimulate faculty recruitment and program development in areas that reflect the ongoing evolution of HIV/AIDS research and the global epidemic. The Center is comprised of 163 Center members from 35 Divisions and Departments within UAB funded by current AIDS-related grants and contracts totaling more than $87.2 million. Nine Core Facilities are proposed that provide vital support for the Center's principal thematic areas of viral pathogenesis, experimental therapeutics, global health, prevention and vaccine development. The success of the UAB CFAR in stimulating HIV/AIDS research is reflected in the growth in NIH extramural funding for AIDS-related research from $6.0 million in NIH funding in 1988 to over $26 million currently, in over 2500 research publications over the past six year grant period, in the recruitment of more than 21 HIV/AIDS investigators since 2QQ2, and in the garnering of strong Institutional support.

UAB CFAR的使命是刺激和支持多学科基本， 行为，临床和转化艾滋病研究，以加快艾滋病的有效治疗和预防策略的发展。 20年来，该中心在支持其成员的尖端研究活动中发挥了至关重要的作用，这些研究活动导致了范式转移发现，包括：发现HIV-1 Qarasispecies多样性（自然1988年），HIV-1 RNA的检测在血浆（Science 1993）中，急性和慢性感染中的病毒动力学（NEJM 1991; Nature 1995），HIV-1从细胞毒性T细胞中逃脱（Nat Medicine 1997）和中和抗体（自然，2003年），第一个人类阶段1目前批准疗法的7种临床研究（NEJM 1993; Nat Medicine 1998; JAMA 2006），HIV-1的人畜共患起源（Nature 1999; Nature 2006; Science 2006）和 鉴定传播的HIV-1包膜和负责HIV感染的完整基因组/蛋白质组（PNAS 2008）。连接所有这些发现的一个共同线程是CFAR通过基本和临床研究人员之间有效的合作来促进基本，转化和临床研究的积极参与。 CFAR的目标反映了对创新的多学科艾滋病研究的持续承诺，并包括： 1。为艾滋病毒/艾滋病研究活动提供中央机构的重点，该研究强调CFAR成员和更广泛的艾滋病毒/艾滋病研究社区之间的有效沟通和协作。 2。通过鼓励跨学科研究，并为中心调查人员提供关键的共享资源设施以及行政和财政管理支持，以提高正在进行的研究计划的生产率。 3。使用强大的战略规划方法来确定新的研究机会和优先事项，以使其与现有的CFAR计划保持一致，并培养新的研究计划，除了教师兴趣和大学能力很明显的地方，都不存在。 4。刺激初级和既定教师进入艾滋病毒/艾滋病研究计划的进入。这是通过指导年轻的研究人员和同行评审的发展赠款计划来实现的。 5。刺激教师招聘和计划发展，以反映艾滋病毒/艾滋病研究和全球流行病的持续发展。 该中心由来自UAB内35个部门和部门的163名中心成员组成，由当前与艾滋病有关的赠款和合同总计超过8720万美元。提出了九个核心设施，可为中心的主要主题区域提供病毒发病机理，实验疗法，全球健康，全球健康， 预防和疫苗开发。 UAB CFAR在刺激艾滋病毒/艾滋病研究方面的成功反映在NIH校外资金的增长中，从1988年的6000万美元的NIH资金增加到了当前的2600万美元，目前在过去六年中的2500多家研究出版物中赠款期，在招募超过 21艾滋病毒/艾滋病研究人员自2QQ2以来，并获得了强大的机构支持。