Lifespan/Tufts/Brown Center for AIDS Research (CFAR)

寿命/塔夫茨/布朗艾滋病研究中心 (CFAR)

• 批准号: 8129064
• 负责人: CHARLES CJ CARPENTER
• 金额: $ 78.64万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-21 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8129064
• 关键词: Lifespan; Tufts; Brown; Center; AIDS

The primary goal of this CFAR is to support clinical, basic and translational research designed to improve the prevention and treatment of HIV/AIDS with a major focus on women, racial and ethnic minorities, and individuals with substance abuse problems. A second, and related, goal is to stimulate and support the research career development of NIH funded investigators, particularly those from minority communities. Because of the multi-disciplinary approaches required to achieve the above goals, a third aim is to stimulate cross-disciplinary research involving clinical, social and basic scientists. To provide the essential services to achieve these goals, we have established a Developmental Core; four Clinical Cores (HIV & Women, Prevention Science, Translational Science, and Gl and Nutrition), and two Basic Cores (Retrovirology Services, and Biostatistics and Outcomes). We have established one crossdisciplinary Scientific Program, the International Scientific Program (ISP). Members of the ISP utilize CFAR Core services in collaborative HIV/AIDS research in several resource-restricted nations with high overall HIV prevalence. We have also utilized four flexible, multi-disciplinary Scientific Working Groups (SWGs), each of which has members supported by three or more CFAR Cores. These include Behavioral Science, Neuro-AIDS, Underrepresented Minority Development, and AIDS Malignancy SWGs. More effective means of preventing and treating HIV infection in populations targeted by this research will result in decreasing the overall incidence of HIV infection and the return of a large proportion of persons living with HIV to productive, symptom-free lives, both in the United States and in higher HIV-prevalence areas in Africa and Asia.

该 CFAR 的主要目标是支持旨在改善艾滋病毒/艾滋病预防和治疗的临床、基础和转化研究，重点关注妇女、少数族裔和有药物滥用问题的个人。第二个相关目标是刺激和支持 NIH 资助的研究人员的研究职业发展，特别是来自少数族裔社区的研究人员。由于实现上述目标需要多学科方法，第三个目标是促进临床、社会和基础科学家的跨学科研究。 为了提供实现这些目标的基本服务，我们建立了发展核心；四个临床核心（艾滋病毒与妇女、预防科学、转化科学、胃肠道和营养）和两个基本核心（逆转录病毒学服务、生物统计学和结果）。我们建立了一项跨学科科学计划，即国际科学计划（ISP）。 ISP 的成员利用 CFAR 核心服务在几个艾滋病毒总体患病率较高的资源有限的国家开展艾滋病毒/艾滋病合作研究。我们还利用了四个灵活的多学科科学工作组 (SWG)，每个工作组都有由三个或更多 CFAR 核心支持的成员。其中包括行为科学、神经艾滋病、代表性不足的少数族裔发展和艾滋病恶性肿瘤 SWG。在本研究的目标人群中采取更有效的预防和治疗艾滋病毒感染的方法将导致美国艾滋病毒感染的总体发病率下降，并使大部分艾滋病毒感染者恢复生产性的、无症状的生活以及非洲和亚洲艾滋病毒流行率较高的地区。