TAS:: 75 0872:: TAS LUNG TISSUE RESEACH CONSORTIUM CLINICAL CENTER

塔斯马尼亚州:: 75 0872:: 塔斯马尼亚州肺组织研究联盟临床中心

• 批准号: 8602363
• 负责人: Gerard J Criner
• 金额: $ 35.13万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-03 至 2015-01-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8602363
• 关键词: Blood specimen; Cancer Patient; Chronic Obstructive Airway Disease; Clinical; Clinical Data; Connective Tissue Diseases; Data; Disease; Enrollment; Excision; Future; Hamman-Rich syndrome; Interstitial Lung Diseases; Interstitial Pneumonia; Lung; Lung diseases; National Heart, Lung, and Blood Institute; Nodule; Pathogenesis; Patients; Physiological; Research; Research Personnel; Respiratory physiology; Structure of parenchyma of lung; Tissue Sample; Tissues

The National Heart, Lung and Blood Institute (NHLBI) Lung Tissue Research Consortium (LTRC) was established with the primary purpose of collecting lung tissue and blood samples and a secondary purpose of collecting clinical data, limited exposure data, physiologic studies, and radiographic studies from patients with chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), other related idiopathic interstitial pneumonias (IIP) and interstitial pneumonias associated with connective tissue diseases who undergo medically-indicated lung resection. For the purpose of comparison, lung tissue and similar clinical data will be collected from control subjects who require lung resection. These control subjects will primarily come from cancer patients without poor lung function for whom non-neoplastic tissue can be collected remotely from a nodule or mass and may also come from patients enrolled with suspected interstitial lung disease (ILD) who are shown after pathological examination not to have this disease. All tissue and blood specimens and clinical data will be banked and stored for distribution to future investigators who have approved study proposals and are investigating the pathogenesis of the aforementioned lung diseases.

The National Heart, Lung and Blood Institute (NHLBI) Lung Tissue Research Consortium (LTRC) was established with the primary purpose of collecting lung tissue and blood samples and a secondary purpose of collecting clinical data, limited exposure data, physiologic studies, and radiographic studies from patients with chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), other related idiopathic与接受医学指示的肺切除的结缔组织疾病相关的间质性肺炎（IIP）和间质肺炎。为了进行比较，将从需要肺切除的对照受试者中收集肺组织和类似的临床数据。这些对照受试者将主要来自没有肺功能较差的癌症患者，这些患者可以从结节或肿块中远程收集非肿瘤组织，也可能来自患有可疑间隙肺病（ILD）的患者，这些患者在病理检查后被证明没有这种疾病。所有组织和血液标本和临床数据都将库存并存储，以分配给未来的研究人员，这些研究人员批准了研究建议，并正在研究上述肺部疾病的发病机理。