Neuroprotection in Parkinson Disease: Clinical Center

帕金森病的神经保护：临床中心

• 批准号: 8460675
• 负责人: Rodger Elble
• 金额: $ 7.19万
• 依托单位: SOUTHERN ILLINOIS UNIVERSITY SCH OF MED
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8460675
• 关键词: Caring; Clinical; Coenzyme Q10; Controlled Clinical Trials; Creatine; Double-Blind Method; Enrollment; Funding; Futility; Future; GPI 1485; Goals; Health; Illinois; Minocycline; National Institute of Neurological Disorders and Stroke; Neurodegenerative Disorders; Parkinson Disease; Participant; Phase; Phase III Clinical Trials; Pioglitazone; Placebo Control; Placebos; Randomized; Research; Site; Testing; United States; Universities; Visit; follow-up; medical schools; member; neuroprotection; treatment strategy

DESCRIPTION (provided by applicant): A major goal of research in Parkinson disease (PD) is to develop treatments that will slow or forestall the progression of this common neurodegenerative disease, which afflicts at least 500,000 people in the United States. Southern Illinois University School of Medicine (SIUSM) has been a member of the NINDS Exploratory Trials in Parkinson disease (NET-PD) network since its inception. SIUSM was a productive site in the initial two futility studies of creatine, coenzyme Q10, minocycline, and GPI 1485 and is a high-enrolling site for the ongoing Phase 3 randomized, double-blinded and placebo-controlled clinical trial of creatine (LS1). We are also a site for the futility trial of pioglitazone (FS-ZONE). This application is a request for continued funding as a participating center.

描述（由申请人提供）：帕金森氏病研究（PD）的主要目标是开发会减慢或阻止这种常见神经退行性疾病进展的治疗方法，该疾病会折磨于美国至少500,000人。自成立以来，伊利诺伊州南部大学医学院（SIUSM）一直是帕金森氏病（NET-PD）网络的Ninds探索性试验的成员。 Siusm是肌酸，辅酶Q10，minocycline和GPI的最初两项徒劳研究的生产地点 1485年，是正在进行的3期随机，双盲和安慰剂对照的肌酸临床试验（LS1）的高注射地点。我们还是吡格列酮（FS-Zone）徒劳试验的地点。该申请是作为参与中心继续资助的请求。

项目成果

Impaired pentagon drawing is an early predictor of cognitive decline in Parkinson's disease.

五边形绘图受损是帕金森病认知能力下降的早期预测因素。

• DOI: 10.1002/mds.25807
• 发表时间: 2014
• 期刊: Movement disorders : official journal of the Movement Disorder Society
• 作者: Kaul,Siddharth;Elble,RodgerJ
• 通讯作者: Elble,RodgerJ

What is essential tremor?

• DOI: 10.1007/s11910-013-0353-4
• 发表时间: 2013-06
• 期刊: CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
• 影响因子: 5.6
• 作者: Elble, Rodger J.