2009 Insulin-like Growth Factors in Physiology and Disease Gordon Conference

2009 生理学和疾病中的胰岛素样生长因子戈登会议

• 批准号: 8423719
• 负责人: Peter S Rotwein
• 金额: $ 1.2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-15 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8423719
• 关键词: Address; Affect; Aging; Amino Acids; Area; Binding Proteins; Biology; Blood Vessels; Bone Regeneration; California; Cardiac; Cardiovascular system; Communities; Development; Disease; Fatty acid glycerol esters; Glucose; Goals; Health; Human Biology; Human Development; Hypertrophy; International; Malignant Neoplasms; Metabolic; Metabolism; Muscle Development; Myocardial; Natural regeneration; Participant; Pathology; Pathway interactions; Physiological; Physiology; Proteins; Regenerative Medicine; Regulation; Request for Proposals; Research; Resolution; Scientist; Series; Signal Transduction Pathway; Skeletal Muscle; Somatomedins; Text; Tissues; abstracting; age related; cancer therapy; disorder control; human disease; meetings; posters; programs; receptor binding; symposium; therapeutic target; tumor progression; tumorigenesis

Abstract This proposal requests partial support for an international meeting on Insulin-like Growth Factors in Physiology and Disease as part of the Gordon Research Conference series, and will be held in Ventura, California during March 22 - 27, 2009, with subsequent meetings in 2011 and 2013. The Broad and Long-term Goals of the conference are to increase our understanding of the fundamental mechanisms controlling the actions of these proteins in human biology and disease. The Specific Aims of this meeting will be to convene 25 speakers who will represent critical areas of insulin-like growth factor (IGF) research with a total of 135 participants for a five-day conference in a relatively isolated setting. The program will have a keynote address and eight sessions, which will address current issues in IGF biology as they pertain to aging and age-related diseases, regenerative medicine, cancer (including tumorigenesis, cancer progression, and targeted therapeutics), cardiovascular biology (including control of vascular smooth muscle development and pathology, and regulation of myocardial hypertrophy), metabolic regulation (specifically signal transduction pathways controlling intermediary metabolism), and other aspects of the expression and function of IGFs, their receptors, and binding proteins in normal physiology and human disease. In addition, four afternoon poster sessions will permit all participants to contribute to these topics. The Significance of this application is that the Gordon Research Conference on Insulin-like Growth Factors in Physiology and Disease is a critical component of regular meetings that propels research in the international IGF scientific community. The Health Relatedness of this application is that discussions at this Gordon Research Conference will define key questions that require experimental resolution in areas that affect human development and aging, regeneration and repair of bone, skeletal muscle, and other tissues, cancer therapy, cardiac and vascular development and disease, and the control of glucose, fat, and amino metabolism in normal physiology and disease.

抽象的 该提案要求部分支持戈登研究会议系列的一部分关于生理和疾病的国际胰岛素样增长因素，并将在2009年3月22日至27日在加利福尼亚州的文图拉举行，随后在2011年和2013年举行的会议。会议的广泛和长期目标是为了使我们对这些蛋白质的基本疾病的理解增加了这些蛋白质的理解。这次会议的具体目的是召集25位演讲者，他们将代表类似胰岛素的生长因子（IGF）研究的关键领域，共有135名参与者在相对孤立的环境中进行为期五天的会议。该计划将有一个主题演讲和八个课程，该计划将解决IGF生物学中的当前问题，因为它们与衰老和与年龄有关的疾病有关控制中介代谢的途径以及正常生理和人类疾病中IGF，其受体和结合蛋白的表达和功能的其他方面。此外，四个下午的海报会议将使所有参与者都可以为这些主题做出贡献。该应用的重要性是，戈登（Gordon）在生理和疾病中类似胰岛素样生长因素的研究会议是推动国际IGF科学界研究的常规会议的关键组成部分。该应用的健康相关性是，在本戈登研究会议上的讨论将定义关键问题，这些问题需要在影响人类发育和衰老，骨骼，骨骼肌的再生和修复领域的实验分辨率，骨骼肌肉以及其他组织，癌症治疗，心脏和血管发育和疾病，以及对葡萄糖，脂肪，脂肪，脂肪，脂肪和氨基代谢在正常生理学和疾病中的控制。