Aging and the immune system

衰老与免疫系统

• 批准号: 8529951
• 负责人: BONNIE B. BLOMBERG
• 金额: $ 1万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-15 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8529951
• 关键词: Achievement; Address; African; Age; Aging; American; Area; Asians; B-Lymphocytes; Basic Science; Biological Markers; Cancer Vaccines; Cell Aging; Clinical Immunology; Collaborations; Communities; Congresses; Country; Data; Databases; Development; Disabled Persons; Elderly; Europe; European; Fostering; Funding; Future; Genomics; Goals; Health; Human; Immune; Immune response; Immune system; Immunity; Immunology; Infectious Agent; Intention; International; Intervention; Joints; Letters; Longitudinal Studies; Modeling; Mus; Parents; Paris, France; Pharmacologic Substance; Phenotype; Population; Proteomics; Regulation; Research; Research Personnel; Risk; Scientist; Secure; Societies; Source; Staging; Stem cells; Structure; System; T cell response; T-Lymphocyte; Thymus Gland; Time; Training; United States; Vaccines; cancer stem cell; clinical application; design; experience; forging; handicapping condition; immunological intervention; immunosenescence; meetings; member; microbiome; mortality; mouse model; pathogen; response; symposium; translational study; vaccine development

DESCRIPTION (provided by applicant): This R-13 application seeks partial support for a Satellite Meeting "Aging and the Immune System" in conjunction with the International Congress of Immunology (ICI) to be held in Milan, August 22-27, 2013. This meeting will bring together scientists from all over the world including American and European scientists whose intellectual focus is the immunology of aging. This conference, will take place in Milan on August 20th and 21st, 2013. Here we request funds to allow participation by speakers from the United States. The planned conference will provide an excellent venue for constructive discussions on recent achievements in research on the aging immune system, advantages and limits of the usage of genomics, including the microbiome, as well as methodological development and clinical application in this field, participation from pharmaceutical companies and vaccine development. We expect that this meeting will significantly contribute to a more integrated and better-coordinated European and American research structure in immunogerontology. In addition, we believe that the meeting, particularly with its opposition to the ICI, will attract ne investigators and trainees to the field. This meeting will enforce already existing collaborations and support the creation of new translational studies which will benefit the aging human population. The venue, the Milan Congress Center, MiCo, is the largest conference facility in Europe, opened in 2011, located in downtown Milan and therefore easily accessible by Metrorail and fully handicap accessible. First goal of the meeting is to summarize recent progress in research on immunology of aging, addressing the most important research areas such as adaptive, innate and clinically applied immunology. The second goal is to trigger a critical discussion on the advantages, limits and potential problems of the application of these discoveries to future interventions which can better help the elderly (vaccines). Recent vaccine development, biomarkers to predict responsiveness, and recently discovered interventions will be discussed. The third goal is to design future strategies on (a) how to optimize interaction, networking and collaborations in this specific research field, and (b) how to organize continuous interchange between European and US scientists. Historically, the focus of immunology and aging in the US has been with murine systems, whereas in Europe has mainly been with humans. This meeting will allow better interaction not only of the 2 different geographical but also disciplinary groups, and will make a substantial contribution to further strengthen immunogerontology as a distinct, generally accepted field within basic immunology.

说明（由申请人提供）：此 R-13 申请寻求对将于 2013 年 8 月 22 日至 27 日在米兰举行的国际免疫学大会 (ICI) 联合举办的卫星会议“衰老与免疫系统”寻求部分支持。这次会议将汇集来自世界各地的科学家，包括美国和欧洲的科学家，他们的学术重点是衰老免疫学。 本次会议将于 2013 年 8 月 20 日至 21 日在米兰举行。在此，我们请求资金允许来自美国的发言者参加。 计划中的会议将为衰老免疫系统研究的最新成果、包括微生物组在内的基因组学应用的优点和局限性、以及该领域的方法学发展和临床应用、制药公司的参与提供建设性讨论的绝佳场所。公司和疫苗开发。我们期望这次会议将为欧洲和美国免疫老年学研究结构的更加一体化和更好的协调做出重大贡献。 此外，我们相信这次会议，尤其是其反对 ICI 的会议，将吸引新的调查人员和受训人员前往该领域。这次会议将加强现有的合作，并支持创建新的转化研究，这将有利于人口老龄化。举办地点 MiCo 米兰会议中心是欧洲最大的会议设施，于 2011 年开业，位于米兰市中心，因此可通过地铁轻松抵达，并设有无障碍通道。 会议的首要目标是总结衰老免疫学研究的最新进展，涉及最重要的研究领域，例如适应性免疫学、先天免疫学和临床应用免疫学。 第二个目标是引发一场批判性讨论，讨论将这些发现应用于未来干预措施的优点、局限性和潜在问题，以更好地帮助老年人（疫苗）。将讨论最近的疫苗开发、预测反应性的生物标志物以及最近发现的干预措施。 第三个目标是设计未来的战略：（a）如何优化该特定研究领域的互动、网络和合作，以及（b）如何组织欧洲和美国科学家之间的持续交流。 从历史上看，美国免疫学和衰老的焦点一直是小鼠系统，而在欧洲主要是人类。这次会议不仅将促进两个不同地理群体和学科群体之间更好的互动，并将为进一步加强免疫老年学作为基础免疫学中一个独特的、普遍接受的领域做出重大贡献。