Biodemography and Genomics of Aging Trajectories and Plasticity in a Social Model

社会模型中衰老轨迹和可塑性的生物人口学和基因组学

• 批准号: 8628983
• 负责人: Olav Rueppell
• 金额: $ 14.35万
• 依托单位: UNIVERSITY OF NORTH CAROLINA GREENSBORO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8628983
• 关键词: Address; Adult; Affect; Age; Aging; Aging-Related Process; Apidae; Apis; Area; Bees; Behavior; Behavioral; Biological; Biological Models; Complex; DNA Methylation; Dedications; Demographic Analyses; Development; Dimensions; Disease; Early identification; Environment; Epigenetic Process; Evaluation; Evolution; Fostering; Funding; Gene Expression; Gene Expression Profile; Genes; Genomics; Goals; Health; Honey; Housing; Human; Individual; Intervention; Knowledge; Lead; Life; Life Experience; Life Stress; Link; Longevity; Mediating; Medical; Mentors; Mites; Modeling; Molecular; Molecular Profiling; Organism; Parasites; Pattern; Plastics; Policy Making; Population; Process; Regulation; Research; Research Activity; Role; Social Behavior; Social Environment; Social status; Stress; Students; Sum; Surveys; Time; Tissues; Urticaria; Variant; age related; base; behavior influence; biodemography; biological systems; biomedical scientist; cohort; comparative; cost; experience; functional decline; genetic analysis; genome-wide; innovation; insight; life history; methylome; mortality; next generation; normal aging; novel; public health relevance; research study; response; senescence; social; social model; social stress; stressor; Address; Adult; Affect; Age; Aging; Aging-Related Process; Apidae; Apis; Area; Bees; Behavior; Behavioral; Biological; Biological Models; Complex; DNA Methylation; Dedications; Demographic Analyses; Development; Dimensions; Disease; Early identification; Environment; Epigenetic Process; Evaluation; Evolution; Fostering; Funding; Gene Expression; Gene Expression Profile; Genes; Genomics; Goals; Health; Honey; Housing; Human; Individual; Intervention; Knowledge; Lead; Life; Life Experience; Life Stress; Link; Longevity; Mediating; Medical; Mentors; Mites; Modeling; Molecular; Molecular Profiling; Organism; Parasites; Pattern; Plastics; Policy Making; Population; Process; Regulation; Research; Research Activity; Role; Social Behavior; Social Environment; Social status; Stress; Students; Sum; Surveys; Time; Tissues; Urticaria; Variant; age related; base; behavior influence; biodemography; biological systems; biomedical scientist; cohort; comparative; cost; experience; functional decline; genetic analysis; genome-wide; innovation; insight; life history; methylome; mortality; next generation; normal aging; novel; public health relevance; research study; response; senescence; social; social model; social stress; stressor

DESCRIPTION (provided by applicant): My long-term goal is to understand the relation between aging and social evolution at the genomic, organismal, and biodemographic level. I use the comparative honey bee model that offers many experimental opportunities to study epigenetic influences on aging in a highly social context under natural conditions. These studies can yield new insights of general relevance into aging processes and generate novel hypotheses or concepts to stimulate human aging studies. Based on our previous demographic studies and findings that honey bees senescence is more influenced by social status and behavior than by chronological age, I propose to study the plastic aging patterns in honey bee workers further to address the questions how early life stressors, adult behavior, and social interventions determine individual life history trajectories. The predicted influences will be furter studied in surveys of the bees' transcriptome and methylome to elucidate genomic signatures of the exceptional aging plasticity of honey bees. The proposal has the following specific aims: 1) Identification of early developmental and behavioral influences on aging: The effect of parasite stress during development on mortality patterns will be studied with adult behavior as covariate. 2) Description of gene expression patterns and epigenetic mechanisms that underlie the social regulation of aging plasticity: Transcriptome and methylome profiles in specific tissues will be compared at three time points between stressed and unstressed individuals that experience normal aging or experimental aging reversal. All experiments will be conducted in large cohorts of individually identifiable workers housed in observation hives to enable demographic analyses. Motivated by previous studies, recent methodological advances and the growing need for a comprehensive understanding of aging, this proposal is timely and innovative. It addresses fundamental gerontological questions in a uniquely-suited model system. It will provide novel insights that illuminate the social dimension of aging in an experimental biological system to generate new hypotheses for future research. The funding would allow me to expand my dedication to mentoring student research and fostering the next generation of biomedical scientists.

描述（由申请人提供）：我的长期目标是了解基因组，生物和生物人口统计学水平上衰老与社会进化之间的关系。我使用了比较的蜜蜂模型，该模型提供了许多实验机会来研究对自然条件下高度社会环境中衰老的影响。这些研究可以产生对衰老过程的一般相关性的新见解，并产生新颖的假设或概念以刺激人类衰老研究。基于我们以前的人口统计研究和发现，蜜蜂衰老比按年代年龄更大的社会地位和行为影响更大，我建议进一步研究蜜蜂工人中的塑性老化模式，以解决早期生活压力，成人行为和社会干预如何决定个人生活历史的问题。预测的影响将在蜜蜂转录组和甲基甲基体的调查中进行研究，以阐明蜜蜂蜂蜜蜜蜂的特殊老化可塑性的基因组特征。该提案具有以下特定目的：1）鉴定早期发育和行为对衰老的影响：将研究以成年行为为协变量，研究发育过程中寄生虫应力对死亡率模式的影响。 2）在衰老可塑性的社会调节基础的基因表达模式和表观遗传机制中：将在特定组织中的转录组和甲基谱分布在压力正常和实验性衰老逆转的压力和无压力个体之间的三个时间点进行比较。所有实验都将在观察室中容纳的大量单独识别工人中进行，以实现人口统计学分析。在先前的研究中，最近的方法论进步以及对衰老的全面了解的日益增长的需求是及时且创新的。它解决了独特的模型系统中的基本老年学问题。它将提供新颖的见解，从而阐明实验生物系统中衰老的社会层面，从而为未来的研究产生新的假设。这笔资金将使我能够将自己的奉献精神扩展到指导学生研究并培养下一代生物医学科学家。