Hyperpolarizer for 13C MR Metabolic Imaging of Human Subjects and Animal Models

用于人类受试者和动物模型 13C MR 代谢成像的超极化器

• 批准号: 8333704
• 负责人: Daniel M Spielman
• 金额: $ 200万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8333704
• 关键词: 2,4-Dinitrophenol; Advanced Development; Animal Model; Animals; Biomedical Research; Cell Nucleus; Clinic; Communities; Development; Disease; Ensure; Funding; Goals; Grant; Health; Healthcare; Heart Diseases; Human; Image; Investments; Laboratories; Magnetic Resonance Imaging; Malignant Neoplasms; Metabolic; Methods; Mission; Molecular Medicine; National Center for Research Resources; Noise; Nuclear; Pathology; Patient Care; Play; Radiology Specialty; Research; Role; Services; Signal Transduction; Stem cells; Technology; Translations; Universities; bioimaging; cellular imaging; human subject; imaging modality; improved; insight; instrumentation; magnetic resonance spectroscopic imaging; molecular imaging; pre-clinical; programs; response

DESCRIPTION (provided by applicant): This proposal is in response to the NCRR "High End Instrumentation Grant Program S10" (RFA: PAR-11- 228) to expand our investment in improved instrumentation for the advancement of biomedical research in Stanford's interdisciplinary programs including the Richard M. Lucas Center for Imaging (Lucas Center), Center for Biomedical Imaging at Stanford (CBIS), and the Molecular Imaging Program at Stanford (MIPS). Translational biomedical research is of the utmost importance today and, with the rapid advances in molecular medicine and stem cells, imaging plays a vital role. We are requesting funds to purchase a General Electric Healthcare Spinlab" dynamic nuclear polarizer needed to extend our current 13C magnetic resonance spectroscopic imaging (MRSI) efforts. Specifically, we have built a highly successful experimental hyperpolarized 13C metabolic imaging program, but, so far, only technical research and small animal studies have been conducted due to the limitations of our pre-clinical polarizer. The proposed new polarizer will allow us to build upon this program with the additional capability of performing large animal and human studies, a critical step forward in the development of this promising technology. Providing more than a 10,000 fold increase in signal-to-noise ratio (SNR) as compared to thermally polarized 13C nuclei, hyperpolarized MRS forms an important bridge between MRI and molecular imaging, and the new polarizer will enable sophisticated metabolic imaging studies of cancer, heart disease, and other pathologies while ensuring the continued development of advanced hyperpolarized 13C MRS methods for years to come. The Spinlab polarizer will be located within the Lucas Center, which operates as a university Service Center and as an NCRR-funded National Research Resource (Center for Advanced MR Technology at Stanford), supplying state-of-the-art MR instrumentation and services to the campus and broader research community. A primary mission of the Stanford Department of Radiology is the translation of promising new imaging modalities from the laboratory setting to the clinic. The acquisition of this new DNP polarizer is directly aligned with this goal and has great potential to provide new insights into health and disease, ultimately improving patient care.

描述（由申请人提供）：该提案是对NCRR“高端仪器赠款计划S10”（RFA：PAR-11-228）的响应斯坦福（MIPS）。翻译生物医学研究至今至关重要，并且随着分子医学和干细胞的快速发展，成像起着至关重要的作用。我们要求资金购买一家通用的电力医疗旋转灯光“动态核偏光剂，以扩展我们当前的13C磁共振光谱成像（MRSI）的努力。具体来说，我们已经建立了一项非常成功的实验性超极化13C代谢成像程序，但到目前为止，仅允许我们的隔离度构建的层面化学技术，这使得启用了这些隔离度的启示。 additional capability of performing large animal and human studies, a critical step forward in the development of this promising technology. Providing more than a 10,000 fold increase in signal-to-noise ratio (SNR) as compared to thermally polarized 13C nuclei, hyperpolarized MRS forms an important bridge between MRI and molecular imaging, and the new polarizer will enable sophisticated metabolic imaging studies of cancer, heart disease, and other pathologies while ensuring the continued development of advanced超极化13C MRS方法已有几年。 SpinLab偏光层将位于卢卡斯中心，该中心是大学服务中心，并作为NCRR资助的国家研究资源（斯坦福大学高级MR技术中心），为校园和更广泛的研究社区提供最先进的MR仪器和服务。斯坦福大学放射学系的主要任务是将有希望的新成像方式从实验室环境转变为诊所。收购 新的DNP偏光层直接与这个目标保持一致，并具有对健康和疾病的新见解，最终改善了患者护理。

项目成果

PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose.

• DOI: 10.18632/oncotarget.19630
• 发表时间: 2017-10-31
• 期刊: Oncotarget
• 作者: Tee SS;Park JM;Hurd RE;Brimacombe KR;Boxer MB;Massoud TF;Rutt BK;Spielman DM
• 通讯作者: Spielman DM