Ontogeny of sociality in a mouse model

小鼠模型中社会性的个体发育

基本信息

批准号：
8324039
负责人：
JEFFREY R ALBERTS
金额：
$ 30.27万
依托单位：
TRUSTEES OF INDIANA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-08-01 至 2014-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8324039
关键词：
Accounting Adopted Altruism Behavior Behavioral Biological Assay Brain Cutaneous Data Development Diagnosis Dimensions Endocrine Engineering Environment Esthesia Expenditure Foundations Gene Expression Genomics Goals Group Affiliation Growth Health Homeostasis House mice Individual Infant Investigation Isotopes Knockout Mice Knowledge Laboratory mice Learning Life Link Mammals Maternal Behavior Measures Mental disorders Metabolic Methods Metric Modeling Mothers Mus Neurosecretory Systems Odors Organism Other Genetics Outcome Oxytocin Partner in relationship Pattern Physiological Physiology Process Rattus Research Role Schizophrenia Social Behavior Social Development Specificity Temperature Testing Thermogenesis United States National Institutes of Health Work autism spectrum disorder base design experience genetic analysis member mouse model novel offspring postnatal preference programs pup response social tool

项目摘要

DESCRIPTION (provided by applicant): Sociality is the dimension of behavior that brings organisms into association with others, especially other members of one's species and affords all the vital interactions that represent phenomena such group affiliation, mate choice, parental behaviors, information exchange, and altruism. Sociality exists on the level of the individual and on the level of the group, and each has a separable, but interrelated development. The proposed research is designed to define and identify the onset of sociality in Mus musculus, the major "model" mammal serving the NIH Roadmap. We propose a program of research that will employ observational, experiential, physiological, genomic and neuroendrocrine approaches to recognizing when social responses are first expressed by infant mouse pups, how their social behavior becomes directed at other mice, and the rules that govern individual and group behavior. The Specific Aims of the proposed research include: establishing for the C57 strain of laboratory mouse, a set of group and individual phenomena that represent their early social behaviors; creating parametric, foundation data on metabolic effort by individuals and groups so that physiological (especially thermal) effects of contact behavior can be separated from non-thermal, social affiliations. Throughout the research, we will also invoke selected genetically-engineered ("knock out") mice to both test specific hypotheses concerning the roles of cutaneous temperature sensation and the central oxytocin in the formation and expression of filial behavior. Sociality in individual development will be analyzed, especially the development of olfactory preferences that make specific individual's filial responses. Novel "olfactory isotopes" will be used to discover the developmental determinants that derive from specific experiences in the nest with mother and littermates. These constitute probes into how natural experiences serve as learning mechanisms in behavioral development. Finally, we will provide both global and specific measures of maternal behavior in the C57 mother mouse, for these data and their methods are needed for complete analyses of genetic and other experimental contributions to development, since many of these manipulations can operate by altering in maternal behavior. Maternal responses to genomically-altered litters and individuals will be studied to test these ideas. PUBLIC HEALTH RELEVANCE: The importance of the proposed research will be seen first in its contribution to linking objective and quantitative metrics of social behavior to modern knowledge of gene expression and endocrine processes in the brain. This linkage in a mouse model will provide a needed research tool for testing treatments for the many forms of mental illness, such as the autism spectrum disorders and schizophrenia, that involve fundamental disruptions in social processes and social responses.

描述（由申请人提供）：社会性是一种行为维度，它使生物体与其他生物体（尤其是同一物种的其他成员）建立联系，并提供代表群体归属、配偶选择、亲代行为、信息交换等现象的所有重要相互作用。利他主义。社会性存在于个人层面和群体层面，两者都有各自独立而又相互关联的发展。拟议的研究旨在定义和确定小家鼠（Mus musculus）社交性的开始，小家鼠是服务于 NIH 路线图的主要“模型”哺乳动物。我们提出了一个研究计划，将采用观察、经验、生理、基因组和神经内分泌方法来识别幼鼠何时首次表达社交反应，它们的社交行为如何针对其他小鼠，以及管理个体和群体的规则行为。拟议研究的具体目标包括：为实验室小鼠 C57 品系建立一组代表其早期社会行为的群体和个体现象；创建有关个人和群体代谢努力的参数化基础数据，以便将接触行为的生理（尤其是热）影响与非热、社会关系分开。在整个研究过程中，我们还将调用选定的基因工程（“敲除”）小鼠来测试有关皮肤温度感觉和中枢催产素在孝顺行为的形成和表达中的作用的特定假设。将分析个体发展中的社会性，特别是做出特定个人孝顺反应的嗅觉偏好的发展。新型“嗅觉同位素”将用于发现发育决定因素，这些决定因素源自与母亲和同窝动物在巢中的特定经历。这些构成了对自然体验如何作为行为发展中的学习机制的探讨。最后，我们将提供 C57 母鼠母体行为的全局和具体测量，因为这些数据及其方法是对遗传和其他实验对发育的贡献进行完整分析所需要的，因为许多这些操作可以通过改变母体小鼠的母体行为来进行。行为。将研究母亲对基因组改变的窝和个体的反应，以检验这些想法。公共卫生相关性：拟议研究的重要性首先体现在它将社会行为的客观和定量指标与大脑基因表达和内分泌过程的现代知识联系起来的贡献。小鼠模型中的这种联系将为测试多种形式的精神疾病的治疗提供所需的研究工具，例如自闭症谱系障碍和精神分裂症，这些疾病涉及社会过程和社会反应的根本破坏。