Ontogeny of sociality in a mouse model

小鼠模型中社会性的个体发育

基本信息

批准号：
8324039
负责人：
JEFFREY R ALBERTS
金额：
$ 30.27万
依托单位：
TRUSTEES OF INDIANA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-08-01 至 2014-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8324039
关键词：
Accounting Adopted Altruism Behavior Behavioral Biological Assay Brain Cutaneous Data Development Diagnosis Dimensions Endocrine Engineering Environment Esthesia Expenditure Foundations Gene Expression Genomics Goals Group Affiliation Growth Health Homeostasis House mice Individual Infant Investigation Isotopes Knockout Mice Knowledge Laboratory mice Learning Life Link Mammals Maternal Behavior Measures Mental disorders Metabolic Methods Metric Modeling Mothers Mus Neurosecretory Systems Odors Organism Other Genetics Outcome Oxytocin Partner in relationship Pattern Physiological Physiology Process Rattus Research Role Schizophrenia Social Behavior Social Development Specificity Temperature Testing Thermogenesis United States National Institutes of Health Work autism spectrum disorder base design experience genetic analysis member mouse model novel offspring postnatal preference programs pup response social tool

项目摘要

DESCRIPTION (provided by applicant): Sociality is the dimension of behavior that brings organisms into association with others, especially other members of one's species and affords all the vital interactions that represent phenomena such group affiliation, mate choice, parental behaviors, information exchange, and altruism. Sociality exists on the level of the individual and on the level of the group, and each has a separable, but interrelated development. The proposed research is designed to define and identify the onset of sociality in Mus musculus, the major "model" mammal serving the NIH Roadmap. We propose a program of research that will employ observational, experiential, physiological, genomic and neuroendrocrine approaches to recognizing when social responses are first expressed by infant mouse pups, how their social behavior becomes directed at other mice, and the rules that govern individual and group behavior. The Specific Aims of the proposed research include: establishing for the C57 strain of laboratory mouse, a set of group and individual phenomena that represent their early social behaviors; creating parametric, foundation data on metabolic effort by individuals and groups so that physiological (especially thermal) effects of contact behavior can be separated from non-thermal, social affiliations. Throughout the research, we will also invoke selected genetically-engineered ("knock out") mice to both test specific hypotheses concerning the roles of cutaneous temperature sensation and the central oxytocin in the formation and expression of filial behavior. Sociality in individual development will be analyzed, especially the development of olfactory preferences that make specific individual's filial responses. Novel "olfactory isotopes" will be used to discover the developmental determinants that derive from specific experiences in the nest with mother and littermates. These constitute probes into how natural experiences serve as learning mechanisms in behavioral development. Finally, we will provide both global and specific measures of maternal behavior in the C57 mother mouse, for these data and their methods are needed for complete analyses of genetic and other experimental contributions to development, since many of these manipulations can operate by altering in maternal behavior. Maternal responses to genomically-altered litters and individuals will be studied to test these ideas. PUBLIC HEALTH RELEVANCE: The importance of the proposed research will be seen first in its contribution to linking objective and quantitative metrics of social behavior to modern knowledge of gene expression and endocrine processes in the brain. This linkage in a mouse model will provide a needed research tool for testing treatments for the many forms of mental illness, such as the autism spectrum disorders and schizophrenia, that involve fundamental disruptions in social processes and social responses.

描述（由申请人提供）：社会性是行为的维度，将生物体与他人（尤其是一个人的其他成员）相关，并提供了代表现象的所有重要相互作用，例如群体隶属关系，伴侣选择，父母行为，信息交流和利他主义。社会性存在于个人的水平和群体的水平上，每个人都有一个可分离但相互关联的发展。拟议的研究旨在定义和确定Mus Musculus的社会性发作，Mus Musculus是为NIH路线图服务的主要“模型”。我们提出了一项研究计划，该计划将采用观察性，经验，生理，基因组和神经内分泌方法，以识别何时首先由婴儿小鼠幼崽表达社会反应，他们的社交行为如何针对其他小鼠以及管理个人和群体行为的规则。拟议研究的具体目的包括：为C57实验室小鼠菌株建立，这是一组代表其早期社会行为的群体和个人现象；创建有关个人和群体代谢努力的参数基础数据，以便可以将接触行为的生理（尤其是热）影响与非热，社会隶属关系分开。在整个研究中，我们还将调用选定的遗传学工程（“敲除”小鼠，以测试有关皮肤温度感觉的作用和中央催产素在形成和表达货物行为中的作用的特定假设。将分析个体发展中的社会性，尤其是嗅觉偏好的发展，这些偏好使人的申请回应。新颖的“嗅觉同位素”将用于发现与母亲和同窝同夫人在巢穴中的特定经验中获得的发展决定因素。这些构成了自然体验如何作为行为发展中的学习机制的探测。最后，我们将在C57母鼠中同时提供孕产妇行为的全球和特定量度，因为这些数据及其方法需要对遗传和对发育的其他实验贡献进行完整分析，因为许多这些操作可以通过改变母体行为来运作。将研究对基因组改变的垃圾和个人的孕产妇反应，以测试这些想法。公共卫生相关性：拟议研究的重要性将首先出现在将社会行为的客观和定量指标与大脑中基因表达和内分泌过程的现代知识联系起来的贡献中。鼠标模型中的这种联系将提供一种需要的研究工具，用于测试许多形式的精神疾病的治疗，例如自闭症谱系障碍和精神分裂症，涉及社会过程和社会反应中的根本破坏。