Stromal Regulation of Bone Metastasis

骨转移的基质调节

基本信息

批准号：
8505003
负责人：
RAGHU KALLURI
金额：
$ 90.19万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-26 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8505003
关键词：
Accounting Affect Animals Area Autopsy Behavior Biology Cancer Etiology Cancer Patient Cells Cessation of life Diagnosis Disease Disseminated Malignant Neoplasm Distant Elements Engraftment Exhibits Fostering Gene Mutation Genes Genetic Genetic Determinism Genetic Screening Hypoxia Instruction Laboratories Lead Life Malignant Neoplasms Malignant neoplasm of lung Malignant neoplasm of prostate Mesenchymal Metabolic Metastatic Lesion Metastatic Neoplasm to the Bone Metastatic Prostate Cancer Molecular Myofibroblast Neoplasm Metastasis Organ Patients Pharmaceutical Preparations Population Prostate Prostatic Diseases Prostatic Neoplasms Regulation Role Skeleton System Therapeutic bone bone cell cell type design epithelial to mesenchymal transition in vivo insight men metastatic process mortality mouse model neoplastic cell new therapeutic target preclinical study preference programs prostate cancer cell stem tumor tumor microenvironment

项目摘要

DESCRIPTION (provided by applicant): Cancer accounts for 8-9 million deaths a year, 80% of which are due to systemic spread of cancer to distant organs. It has long been recognized that primary cancers spread to distant organs with 'specific' preference, and skeleton/bone is one of the most common organs to be affected by metastatic cancer. Among primary cancers, prostate cancer is considered to be an orthotropic tumor with specific predilection to form bone metastasis. Over 70% of prostate cancer patients exhibit bone metastasis as detected during the disease course or autopsies. Prostate cancers are amongst the most commonly diagnosed malignancies and the 2nd leading cause of cancer death in men. Bone metastases are the predominant reason for prostate cancer related deaths, and current therapies have very short-term benefits, if any. To achieve the central objective, the laboratories of Kalluri, Pandolfi and Scadden have joined forces to propose a focused and cohesive plan to study the biology of bone metastasis. The three projects in this TMEN network will generate new genetic mouse models of metastatic prostate cancer, offer new insights into the biology of prostate cancer initiating cells, identify possible bone metastasis cell of origin, establish the role of tumor microenvironment in metastatic prostate cancer with specific emphasis on prostate and bone microenvironment, identify new therapeutic targets against metastatic prostate cancer and evaluate a new drugs for metastatic prostate cancer in pre-clinical trials. Successful completion of this proposed network proposal will offer significant new advances in area of metastatic prostate cancer.

描述（由申请人提供）：癌症每年占8至900万人死亡，其中80％是由于癌症向遥远的器官的全身传播所致。长期以来，人们已经认识到，原发性癌症传播到具有“特定”偏好的远处器官，而骨骼/骨骼是受转移性癌症影响的最常见器官之一。在原发性癌症中，前列腺癌被认为是一种具有特异性倾向的正交性肿瘤，形成骨转移。超过70％的前列腺癌患者表现出疾病或尸检期间发现的骨转移。前列腺癌是最常见的恶性肿瘤，也是男性癌症死亡的第二大原因。骨转移是前列腺癌与死亡相关的主要原因，当前的疗法具有非常短期的益处（如果有）。为了实现中心目标，卡卢里，潘多尔夫和斯卡德登的实验室联合起来提出了一项重点和凝聚力的计划，以研究骨转移的生物学。 The three projects in this TMEN network will generate new genetic mouse models of metastatic prostate cancer, offer new insights into the biology of prostate cancer initiating cells, identify possible bone metastasis cell of origin, establish the role of tumor microenvironment in metastatic prostate cancer with specific emphasis on prostate and bone microenvironment, identify new therapeutic targets against metastatic prostate cancer and evaluate a new drugs for临床前试验中的转移性前列腺癌。该提出的网络提案的成功完成将在转移性前列腺癌领域提供重大进步。