Complications of Chronic Viral Infections

慢性病毒感染的并发症

基本信息

批准号：
8091301
负责人：
MARSHALL J GLESBY
金额：
$ 18.25万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-07-01 至 2013-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8091301
关键词：
AIDS clinical trial group Area Blood Banks Brazil Chronic Clinic Clinical Clinical Investigator Clinical Research Clinical Trials Cohort Studies Collaborations Commit Cross-Sectional Studies Diabetes Mellitus Disease Doctor of Philosophy Double-Blind Method Education Environment Faculty Fatty acid glycerol esters Funding Genotype Goals Grant HIV HIV-1 Hepatitis C virus Homocysteine Homocystine Human T-lymphotropic virus 1 Infection Insulin Resistance International Medial Medical Students Mentors Metabolic Mid-Career Clinical Scientist Award (K24)National Institute of Allergy and Infectious Disease Natural History Newly Diagnosed Oxidative Stress Patients Pilot Projects Pioglitazone Plasma Postdoctoral Fellow Protocols documentation Public Health Randomized Research Research Design Research Methodology Research Personnel Research Project Grants Resources Ribavirin Stream Thick Time Training Tropical Disease United States National Institutes of Health Universities Virus Diseases Visceral Woman base career design improved in vivo international center member neglect next generation patient oriented research placebo controlled study programs r-hGH-M rosiglitazone skills

项目摘要

DESCRIPTION (provided by applicant): The goal of this application is to expand my mentoring of medical students, post-doctoral fellows, and junior faculty in the conduct of patient-oriented research. My career has been devoted to conducting high quality patient-oriented research in the area of complications of chronic viral infections, with a focus on HIV disease. As the recipient of outstanding mentoring and training, including a PhD in Clinical Investigation, I am committed to training the next generation of clinical investigators. My longstanding research in the area of metabolic complications of HIV and its therapy and recent research in another chronic retroviral infection, HTLV-1 infection in Brazil, as detailed in the following specific aims, will serve as vehicles for training clinical investigators domestically and internationally: 1) To investigate metabolic complications of HIV disease and its therapy; 2) To investigate metabolic complications of HCV/HIV co-infection; and, 3) To characterize the clinical manifestations of HTLV-1 infection. Specific clinical research projects that are funded by R01-DK065515, a supplement from NIAID, and the AIDS Clinical Trials Group, in conjunction with an outstanding institutional environment and resources for education, will enable me to train the next generation of investigators in high quality, hypothesis-driven, patient-oriented research. Furthermore, support from the Fogarty International Center and a T32 training grant will provide a steady stream of high quality domestic and international trainees. This application describes a detailed mentoring plan for trainees, which includes the K30 Masters in Clinical Investigation program for which I developed and co-direct a Clinical Trials course. At this juncture in my career, the protected time afforded by a K24 award is critical to allow me to expand my domestic and international clinical research programs and mentoring activities. To date, I have been able to use my methodologic skills to improve the quality of patient-oriented research being conducted as part of the longstanding NIH-funded Cornell-Bahia collaboration in tropical diseases research. The K24 award will permit me to increase collaborations with colleagues at the Federal University of Bahia in Brazil, assisting in the design, conduct, and analysis of patient-oriented research in neglected tropical diseases of public health importance, including HTLV-1 infection.

描述（由申请人提供）：本申请的目标是扩大我对医学生、博士后研究员和初级教师进行以患者为导向的研究的指导。我的职业生涯一直致力于在慢性病毒感染并发症领域开展高质量的、以患者为导向的研究，重点是艾滋病毒疾病。作为出色的指导和培训（包括临床研究博士学位）的接受者，我致力于培训下一代临床研究人员。我在艾滋病毒代谢并发症及其治疗领域的长期研究以及最近在巴西对另一种慢性逆转录病毒感染（HTLV-1感染）的研究，如以下具体目标所述，将作为培训国内外临床研究人员的工具： 1) 研究HIV疾病的代谢并发症及其治疗； 2) 研究HCV/HIV合并感染的代谢并发症； 3) 表征 HTLV-1 感染的临床表现。由 R01-DK065515（NIAID 的补充）和艾滋病临床试验组资助的具体临床研究项目，加上出色的机构环境和教育资源，将使我能够以高质量、假设驱动、以患者为导向的研究。此外，福格蒂国际中心的支持和T32培训补助金将为国内外提供源源不断的高素质学员。该应用程序描述了针对学员的详细指导计划，其中包括我为该项目开发并共同指导临床试验课程的 K30 临床研究硕士项目。在我职业生涯的这个关头，K24 奖项提供的受保护时间对于我扩大国内和国际临床研究项目和指导活动至关重要。迄今为止，我已经能够利用我的方法学技能来提高以患者为导向的研究的质量，该研究是美国国立卫生研究院资助的康奈尔-巴伊亚热带病研究长期合作的一部分。 K24 奖将使我能够加强与巴西巴伊亚联邦大学同事的合作，协助设计、开展和分析针对具有公共卫生重要性的被忽视的热带疾病（包括 HTLV-1 感染）的以患者为导向的研究。