Temporal Organization of Memory in the Hippocampus

海马体记忆的时间组织

基本信息

批准号：
8449296
负责人：
Howard B. Eichenbaum
金额：
$ 39.29万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8449296
关键词：
Area Cells Code Cognition Cognition Disorders Cognitive Complement Cues Dimensions Environment Episodic memory Event Exhibits Fire - disasters Funding Generations Goals Hippocampus (Brain)Human Learning Life Location Maps Medial Memory Mental disorders Methods Modification Muscimol Names Nature Neurons Optics Pattern Performance Prefrontal Cortex Property Reporting Resolution Schizophrenia Signal Transduction Sleep System Testing Time Work base entorhinal cortex experience memory retrieval millisecond neural circuit neuromechanism prevent relating to nervous system spatiotemporal therapy development way finding

Area Cells Code Cognition Cognition Disorders Cognitive Complement Cues Dimensions Environment Episodic memory Event Exhibits Fire - disasters Funding Generations Goals Hippocampus (Brain)Human Learning Life Location Maps Medial Memory Mental disorders Methods Modification Muscimol Names Nature Neurons Optics Pattern Performance Prefrontal Cortex Property Reporting Resolution Schizophrenia Signal Transduction Sleep System Testing Time Work base entorhinal cortex experience memory retrieval millisecond neural circuit neuromechanism prevent relating to nervous system spatiotemporal therapy development way finding

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项目摘要

DESCRIPTION (provided by applicant): Episodic memory is characterized by our ability to remember the spatial and temporal context in which events occur. There is substantial evidence that the hippocampal neuronal activity reflects a representation of space but, until recently, little was known about whether or how the hippocampal neurons encode time. However, recent studies by us have shown that hippocampal neuronal activity provides a temporal context signal that contributes to memory. In addition there is now evidence that hippocampal neurons - called time cells - fire during particular moments in a temporally extended experience, similar to hippocampal place cells that fire associated with particular locations in a spatially extended environment. The proposed studies will explore the nature of temporal representation by the hippocampal system and prefrontal cortex. We will test the hypothesis that key properties of time cells are analogous to those of place cells. By simultaneous recordings in multiple areas, we will also test the hypothesis that time cells are paralleled by a periodic representation of time in the medial entorhinal cortex and prefrontal cortex representation that disambiguates overlapping experiences. Using both muscimol and optical silencing methods, we will further test the hypothesis that temporal coding in the hippocampus depends on the medial entorhinal cortex, and that the ability of hippocampal time cells to disambiguate overlapping experiences depends on the prefrontal cortex. These studies will challenge the prevalent view that the hippocampal system is dedicated to spatial navigation and advance our understanding of how this system represents events in their spatiotemporal context.

描述（由申请人提供）：情节记忆的特征是我们记住发生事件的空间和时间上下文的能力。有大量证据表明，海马神经元活性反映了空间的表示，但直到最近，人们对海马神经元的编码时间或如何编码时间知之甚少。但是，我们最近的研究表明，海马神经元活动提供了有助于记忆的时间上下文信号。此外，现在有证据表明，海马神经元（称为时间细胞）在时间扩展的经验中在特定时刻发射，类似于在空间扩展环境中与特定位置相关的海马置换细胞。拟议的研究将通过海马系统和额叶皮层探索时间代表的性质。我们将检验以下假设：时间细胞的关键特性类似于地方细胞的关键特性。通过在多个领域的同时记录，我们还将测试以下假设：时间单元与内侧内嗅皮层和前额叶皮层表示的定期表示，这使时间细胞的时间差异为歧义体验。我们将使用麝香酚和光沉默方法，进一步检验以下假设：海马中的时间编码取决于内侧内嗅皮层，以及海马时间细胞消除重叠经验的能力取决于前额叶皮质。这些研究将挑战普遍的观点，即海马系统致力于空间导航，并促进我们对该系统在时空环境中如何代表事件的理解。