Prefrontal and Medial-Temporal Interactions in Memory

记忆中的前额叶和内侧颞叶相互作用

• 批准号: 8150150
• 负责人: Howard B. Eichenbaum
• 金额: $ 180.78万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-06 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8150150
• 关键词: Prefrontal; Medial; Temporal; Interactions; Memory; Prefrontal; Medial; Temporal; Interactions; Memory

DESCRIPTION (provided by applicant): A fundamental challenge in neuroscience is understanding of how major brain areas operate together as a system to support high level cognitive functions. In particular, one system of great importance to the understanding of mental disorders involves the prefrontal cortex (PFC) and the medial temporal lobe (MTL) that each contribute to high level functions in memory and cognition. In recent years, there has been significant progress in revealing the individual functions of areas within the PFC and MTL, and some successes in showing that these areas work together. However, there is a paucity of knowledge about the mechanisms by which PFC and MTL interact in the service of memory and cognition. Here we bring together a group of investigators who have led research on PFC and MTL, or both, using diverse approaches and different species. We have collaborated to develop an hypothesis of PFC-MTL interactions and aim to integrate our strengths towards revealing the mechanisms of that interaction, and in so doing, pioneer a true systems level understanding of memory and cognition. Our strategy combines theories of PFC and MTL function generated by our group with coordinated experimental analyses that converge on a common behavioral paradigm for exploring encoding and retrieval operations in context-guided associative memory. Experimental projects will examine how PFC and MTL areas contribute individually and interactively, using diverse and intersecting approaches: in humans, using both neuropsychological studies of brain damaged individuals and fMRI on normal human subjects, in monkeys using neurophysiological studies of single neuron activity and local field potentials, in rats using combined neurophysiological and reversible inactivation studies of non-spatial and spatial memory. The findings will be integrated in two key ways, by direct comparison of different data modalities through an Analysis Core and by convergence into a computational model that provides a comprehensive and unified account of PFC-MTL interactions. The Center will also pursue several directly related educational, dissemination, and outreach goals. PUBLIC HEALTH RELEVANCE: PFC and MTL areas are implicated in a broad range of mental disorders. Moreover, it has become increasingly clear that aspects of mental disorders reflect a breakdown of network functions of the PFC-MTL system. Correspondingly, characterization of PFC-MTL interactions is fundamental to understanding the origins of mental disorders and to developing therapies that influence network-level information processing.

描述（由申请人提供）：神经科学中的一个基本挑战是了解主要大脑区域如何作为支持高水平认知功能的系统。特别是，一种对理解精神障碍的重要性的系统涉及前额叶皮层（PFC）和内侧颞叶（MTL），每个系统都会在记忆和认知中促进高水平的功能。近年来，在揭示PFC和MTL内部地区的个体功能方面取得了重大进展，并且在表明这些地区共同起作用方面取得了一些成功。但是，关于PFC和MTL在记忆和认知服务中相互作用的机制的知识很少。在这里，我们将一组研究人员组合在一起，他们使用多种方法和不同的物种领导了PFC和MTL或MTL的研究。我们已经合作开发了PFC-MTL相互作用的假设，并旨在将我们的优势整合到揭示这种相互作用的机制上，并在这样做的过程中，先驱对记忆和认知的真实系统水平的理解。我们的策略结合了我们小组生成的PFC和MTL函数的理论与协调的实验分析，该分析会收敛于在上下文引导的关联记忆中探索编码和检索操作的共同行为范式。实验项目将使用多样化和相交的方法研究PFC和MTL领域如何单独和互动地贡献：在人类中，使用对猴子对正常受试者的神经心理学研究，使用神经元的神经生理学研究在猴子中对正常人类受试者进行正常人类受试者，并使用大鼠进行分散的神经疗法和分散的研究，以进行不合理的研究。这些发现将通过两种关键方式集成，通过通过分析核心直接比较不同的数据模式，并通过收敛到计算模型，该模型提供了PFC-MTL交互的全面统一说明。该中心还将追求几个直接相关的教育，传播和外展目标。 公共卫生相关性：PFC和MTL领域与广泛的精神障碍有关。此外，越来越清楚的是，精神障碍的各个方面反映了PFC-MTL系统网络功能的细分。相应地，PFC-MTL相互作用的表征对于理解精神障碍的起源和开发影响网络级信息处理的疗法至关重要。