Neurophysiological Mechanisms in the Development of Externalizing Problems

外化问题发展中的神经生理学机制

基本信息

批准号：
8649520
负责人：
Isaac T Petersen
金额：
$ 4.22万
依托单位：
TRUSTEES OF INDIANA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-01-01 至 2015-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8649520
关键词：
3 year old Adolescent Adult Age Age-Years Aggressive behavior Attention Attention deficit hyperactivity disorder Autistic Disorder Behavior Behavioral Behavioral Mechanisms Biological Markers Brain Caregivers Categories Child Clinical Skills Complement Conduct Disorder Development Diagnostic Dimensions Disease Disinhibition Drug abuse Dyslexia Early Diagnosis Early identification Electroencephalography Event Event-Related Potentials Family Frequencies Goals Informal Social Control Knowledge Lead Learning Left Link Longitudinal Studies Measures Mediating Neurophysiology - biologic function Nursery Schools Occupational Parents Phenotype Prevention Prevention approach Problem behavior Process Psychopathology Public Health Reporting Research Research Training Risk Risk Factors Risk Marker Role School-Age Population Sensitivity and Specificity Stimulus Substance abuse problem Symptoms Testing Time Toddler Training Translating Work base behavior measurement cost effective early childhood effective intervention experience externalizing behavior innovation neurodevelopment neuromechanism neurophysiology prevent programs public health relevance relating to nervous system response skills tool

项目摘要

DESCRIPTION (provided by applicant): The goal of the proposed project is better understanding of mechanisms in the development of externalizing problems, including conduct and attention problems, with special emphasis on neural mechanisms. From a developmental perspective it is important to study neural functioning in relation to externalizing behavior befor behavior problems have become established. With more knowledge of the processes, early detection and prevention approaches may become more successful. The proposed study appears to be the first to chart the development of neural functioning in relation to externalizing problems in early childhood. The proposed longitudinal research seeks to identify neural mechanisms in the development of externalizing problems among children 2.5-3.5 years of age using event-related potentials (ERPs). ERPs are neural responses to stimuli measured by electroencephalography (EEG), with the potential to be biomarkers for dimensions of psychopathology at earlier ages than when externalizing symptoms typically become salient. The central hypothesis based on previous findings is that ERPs, including the N2 and P3 components, will predict the development of externalizing behavior problems, as mediated by self-regulation deficits. The rationale of the proposed research is that understanding early neural risk factors and mechanisms in externalizing problems may lead to more accurate identification of at-risk children and modifiable intermediate phenotypes. This in turn can lead to more cost-effective interventions and even prevention of behavior problems. The approach is innovative in longitudinally examining neural biomarkers in early childhood as predictors of externalizing problems, dimensions of disinhibition and sustained attention deficits rather than diagnostic categories. The proposed research is significant because it will identify more accurate early developmental mechanisms than behavioral markers by themselves, which may translate to more successful prevention. The proposed research will also identify better early behavioral indicators of the neural mechanisms of externalizing problems. These intermediate phenotypes for externalizing problems can become clinically practical assessment tools in early childhood. The project includes two specific aims: 1) Identify early neural biomarkers of the development of externalizing problems, and 2) Determine mechanisms underlying the development of externalizing problems. Aim 1 will examine whether the N2 and P3 ERP components predict the development of later externalizing problems reported by parents and secondary caregivers. Aim 2 will test whether the N2 and P3 predict later self-regulation deficits on lab tasks, which, in tun, lead to externalizing problems. We will also test other neural biomarkers to increase sensitivity and specificity for predicting the development of later externalizing problems. The study will follow children from 30 to 42 months, an era of accelerated neural development and increased externalizing problems that are becoming stable. Externalizing problems will be reported by parents and secondary caregivers. Self-regulation problems will be measured by behavioral tasks.

描述（由申请人提供）：拟议项目的目标是更好地理解外化问题的发展机制，包括行为和注意力问题，特别强调神经机制。从发展的角度来看，在行为问题出现之前研究与外化行为相关的神经功能非常重要。随着对过程的更多了解，早期检测和预防方法可能会变得更加成功。拟议的研究似乎是第一个绘制与外化相关的神经功能发展的图表幼儿期的问题。拟议的纵向研究旨在利用事件相关电位（ERP）来确定 2.5-3.5 岁儿童外化问题发展的神经机制。 ERP 是通过脑电图 (EEG) 测量的神经对刺激的反应，有可能成为比外化症状通常变得突出的更早年龄的精神病理学维度的生物标志物。基于先前发现的中心假设是，ERP（包括 N2 和 P3 组件）将预测由自我调节缺陷介导的外化行为问题的发展。该研究的基本原理是了解早期的神经元外部化问题的风险因素和机制可能会导致更准确地识别高危儿童和可改变的中间表型。这反过来又可以带来更具成本效益的干预措施，甚至可以预防行为问题。该方法的创新在于纵向检查儿童早期的神经生物标志物，作为外化问题、去抑制维度和持续注意力缺陷的预测因子，而不是诊断类别。拟议的研究意义重大，因为它将识别出比行为标记本身更准确的早期发育机制，这可能转化为更成功的预防。拟议的研究还将确定外化问题神经机制的更好的早期行为指标。这些外化问题的中间表型可以成为幼儿期临床实用的评估工具。该项目包括两个具体目标：1）识别外化问题发展的早期神经生物标志物，2）确定外化问题发展的潜在机制。目标 1 将检查 N2 和 P3 ERP 组件是否可以预测父母和二级照顾者报告的后来外化问题的发展。目标 2 将测试 N2 和 P3 是否可以预测以后实验室任务中的自我调节缺陷，这最终会导致外部化问题。我们还将测试其他神经生物标志物，以提高预测后续外化问题发展的敏感性和特异性。这项研究将跟踪 30 至 42 个月大的儿童，这是一个神经发育加速、外化问题增多且趋于稳定的时期。外化问题将由父母和二级照顾者报告。自我调节问题将通过行为任务来衡量。