Exercise Training in Depressed Traumatic Brain Injury (TBI) Survivors

抑郁性创伤性脑损伤 (TBI) 幸存者的运动训练

基本信息

批准号：
8494649
负责人：
Anne M. Hudak
金额：
$ 13.11万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8494649
关键词：
Academic Medical Centers Adherence Adult Adverse effects Aerobic Exercise Aftercare Antidepressive Agents Appearance Biochemical Biological Biological Markers Brain Brain-Derived Neurotrophic Factor Caring Cognition Cognitive Conflict (Psychology)Data Depressed mood Disease Educational process of instructing Environmental Medicine Exercise Fatigue Fellowship Functional disorder General Population Goals Headache Health Health Benefit Home environment Hospitals Image Imaging Techniques Injury Institutes Institution Intervention Investigation K-Series Research Career Programs Knowledge Link Magnetic Resonance Imaging Measures Mental Depression Mentors Moderate Exercise Oral Outcome Pain Patients Pharmaceutical Preparations Physical Medicine Pilot Projects Placebos Population Protocols documentation Publishing Randomized Recovery Regimen Rehabilitation therapy Reporting Safety Societies Stretching Survivors Taxes Testing Time Training Training and Education Trauma Traumatic Brain Injury United States Vascular Endothelial Growth Factors alternative treatment arm brain volume career depressive symptoms design disability effective therapy hemiparesis improved insight neuroimaging neurotrophic factor phase 3 study post intervention social stigma suicide rate therapeutic target training project

项目摘要

DESCRIPTION (provided by applicant): Traumatic brain injury (TBI) alters the lives of many civilians and those involved in armed conflicts. Sequalae of TBI include depression in up to 30% of cases. Appearance of depression after TBI impairs recovery and results in sub-optimal re-integration into society. Treatment of post TBI depression relies on oral medications, whose efficacy and side effect profile is sub-optimal. Exercise training is effective in spontaneous depression as a stand-alone treatment and in conjunction with oral medications, and this may represent an alternative treatment option in the TBI population. Further, the pathophysiology of depression after TBI has yet to be examined with the full scientific rigor required. This project proposes to use exercise training of moderate intensity as a treatment for depression after TBI, while measuring biological markers as a way to investigate efficacy and provide insight into the pathophysiology. This mentored career development award would allow further training and education of the candidate in exercise training, depression, sophisticated imaging techniques and the analysis of such data. The candidate's career goal is to be an expert in depression after TBI, thereby improving outcome through understanding the pathophysiology and seeking population specific treatments. UT Southwestern is one of the leading academic medical centers in the United States, with a proven record of scientific excellence. Home to four Nobel Laureates, it is also the home institution of world renowned experts in depression and traumatic brain injury. Its major teaching institution, Parkland Memorial Hospital, maintains a Level One trauma designation, caring for 3000 trauma patients annually. Exercise training will take place at the Institute for Exercise and Environmental Medicine.

描述（由申请人提供）：创伤性脑损伤（TBI）改变了许多平民的生活以及参与武装冲突的人的生活。 TBI的Sequalae包括多达30％的病例中的抑郁症。 TBI后抑郁症的出现会损害恢复并导致次级最佳的重新整合到社会中。 TBI后抑郁症的治疗依赖于口服药物，其功效和副作用特征是最佳的。运动训练可有效自发抑郁作为独立治疗，并与口服药物结合使用，这可能代表TBI人群中的另一种治疗选择。此外，TBI后抑郁症的病理生理学尚未通过所需的全部科学严格进行检查。该项目建议将中等强度的运动训练作为TBI后抑郁症的治疗方法，同时测量生物标记，以研究疗效并提供对病理生理学的见解。这项指导的职业发展奖将允许在运动训练，抑郁，复杂的成像技术以及对此类数据的分析中进一步培训和教育候选人。候选人的职业目标是在TBI之后成为抑郁症的专家，从而通过了解病理生理学并寻求人口特定治疗来改善结果。 UT Southwestern是美国领先的学术医疗中心之一，具有卓越的科学卓越记录。它是四个诺贝尔奖获得者的所在地，它也是世界著名专家抑郁症和创伤性脑损伤专家的家乡机构。它的主要教学机构Parkland Memorial Hospital，保持了一级创伤指定，每年照顾3000名创伤患者。运动训练将在运动与环境医学研究所进行。