BIOMEDICAL ANALYSIS OF HUMAN BIOSPECIMENS FOR DIPHR

DIPHR 人体生物样本的生物医学分析

基本信息

批准号：
8740710
负责人：
ERIN ALLEN
金额：
$ 14.66万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-09 至 2014-09-08
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8740710
关键词：
Address Adolescent African American Albumins Aliquot Ancillary Study Behavioral Bioinformatics Biological Markers Biometry Body fat Bone Mineral Contents Calcium Child Child health care Childhood Clinic Contracts Dual-Energy X-Ray Absorptiometry Epidemiologic Studies Epidemiology Health behavior Human Human Development Infant Institutes Laboratories Low Birth Weight Infant Measures Mission Mothers National Institute of Child Health and Human Development Neonatal Newborn Infant Participant Perinatal Physiologic calcification Pre-Eclampsia Pregnancy Prevention Prevention Research Protein Isoforms Race Research Risk Sampling Scanning Serum Severities Shipping Ships Site Supplementation Task Performances Testing Vitamin D Vitamin D Deficiency Vitamin D-Binding Protein Woman design fetal population health repository reproductive

项目摘要

The tasks to utilize this contract are to analyze samples from the Calcium for Preeclampsia Prevention trial (CPEP) to measure total 25(0H)D, its isoforms (25(0H)D2 and 25(0H)D3), Vitamin D binding protein (VDBP), albumin, and total calcium in up to 992 serum samples from the CPEP trial. Period of performance for this task is estimated to be 6 months. The Division of lntramural Population Health Research of the Eunice Kennedy Shriver National Institute of Child Health and Human Development encompasses three branches: 1) Epidemiology Branch; 2) Biostatistics and Bioinformatics Branch and 3) Prevention Research Branch [http://www.nichd.nih.gov/about/org/despr/]. Central to the Division's mission is to design, implement, and direct epidemiologic, behavioral and biostatistical research which focuses on reproductive, perinatal and pediatric epidemiologic research as well as research addressing child and adolescent health behaviors. The Division previously conducted the Calcium for Preeclampsia Prevention (CPEP) trial from 1992-1995 across 5 clinics in the US testing the effect of calcium supplementation on risk and severity of preeclampsia (PE). One of the CPEP study sites (Memphis, TN) conducted an ancillary study of' Fetal bone mineralization' whereby both the mother and her newborn could receive a dual-energy X-ray absorptiometry (DXA) scan. Several studies have shown that . women with vitamin D deficiency during pregnancy tend to have infants with lower birth weight, although the evidence is still controversial. To build on previous findings, we will measure maternal CPEP serum samples for vitamin D biomarkers to investigate maternal vitamin D status in association with neonatal body fat and neonatal bone mineral content. Maternal vitamin D status will also be examined in association with maternal bone mineral content. Serum samples collected longitudinally in this trial will offer several measures of vitamin D status throughout gestation enabling us to better characterize the vitamin D profile of these women. These measures will also be used to characterize the trajectories of vitamin D biomarkers across gestation stratifying by two racial groups namely Whites and African-Americans. Serum samples from the trial have been stored in the NICHD Bio-repository at -70¿C. Aliquots of the participants will be shipped to the laboratory

利用该合同的任务是分析钙的样本以供Preclampsia 预防试验（CPEP）总计25（0H）D，其ISFORM（25（0H）D2和25（0H）D3），维生素D结合蛋白（VDBP），白蛋白，钙钙最多992种血清样品 CPEP试验估计为6个月。 Eunice Kennedy Shriver National的Lntramural Populal人口健康研究部儿童健康与人类发展研究所包括三个分支：1）流行病学分支； 2）生物统计学和生物信息学分支机构3）分支[http://www.nichd.nih.gov/about/org/despr/]。设计，实施和直接流行病学，行为和生物群体主义者专注于生殖，围产期和小儿流行病学研究以及研究解决儿童和青少年健康行为。该部门先前从事预防先兆子痫的钙（CPEP）试验 1992 - 1995年在美国5个诊所中先兆子痫的严重程度（PE）。 “胎儿骨矿化”的辅助研究，母亲和她的新生儿都可以接受双能X射线吸收法（DXA）扫描已表明。列前维生素D缺乏症的女性往往患有较低的出生体重的婴儿， Althooth仍然有争议的证据。维生素D生物标志物研究母体维生素D状态的母体CPEP血清样品与新生儿脂肪和新生儿骨矿物质含量有关还将检查与母体骨矿物质样品相关的状态在这项试验中纵向收集，并提供了整个维生素D状态的优势妊娠使我们能够更好地表征女性的维生素D特征。措施也将用于表征跨维生素D生物标志物的轨迹两个种族群体（即白人和非裔美国人）进行妊娠从试验中存储在-70¿的NICHD BIO替代者中C.等分试样颗粒将运送到实验室