Neurobehavioral Analysis Core

神经行为分析核心

基本信息

批准号：
8659020
负责人：
TONY J SIMON
金额：
$ 13.07万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-24 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8659020
关键词：
Address Adult Autistic Disorder Behavior Behavior assessment Behavioral Bioinformatics Biological Biometry Blood Characteristics Child Clinical Research Clinical Trials Cognition Cognitive Communities Competence Complex Consultations Data Development Down Syndrome Electrophysiology (science)Emotions Ensure Environment Evaluation Experimental Designs Eye Faculty Fragile X Syndrome Genetic Genets Human Individual Infant Institutes Label Laboratories Language MRI Scans Magnetic Resonance Imaging Maps Measurement Measures Mental Retardation and Developmental Disabilities Research Centers Methods Monitor Neurobiology Neurodevelopmental Disorder Other Genetics Outcome Measure Parents Participant Peer Review Pharmacological Treatment Phase Phenotype Physiological Population Preparation Process Production Protocol Compliance Protocols documentation Psychometrics Psychophysiology Publications Recruitment Activity Research Research Design Research Personnel Sampling Scanning School-Age Population Scientist Services Site Structure Syndrome System Technology Testing Time Training Translating Trisomy X syndrome Work biobehavior brain behavior computerized data processing control trial design evidence base experience instrument intellectual and developmental disability interest member neurobehavioral neuropsychological phenome programs relating to nervous system research study social treatment trial visual process visual processing

项目摘要

The primary objective of the UC Davis MIND Institute IDDRC Neurobehavioral Analysis Core (NAC) is to help investigators generate detailed phenotypic characterizations of individuals with Intellectual and Developmental Disabilities (IDD). Phenotypic characterization requires measures that are appropriate for a representative sample of individuals with IDD and are designed, executed, and analyzed with the most precision and fidelity possible. Existing standardized tests, rating scales, and checklists are often not adequate for such characterization and adaptations of such measures or the creation of new measures are required. Moreover, many measures are often applicable to only a very narrow segment of the IDD population of interest. The NAC will assist IDDRC investigators in ensuring that they have the measures needed to generate advanced biobehavioral characterizations that can stand alone, be used to assess environmental contributions to IDD, or provide the evidence base for the development and evaluation of targeted treatments for IDD. To achieve this objective, the NAC will draw on the interdisciplinary expertise and already developed measures of several MIND Institute and UC Davis faculty and staff to provide key services for investigators conducting neurobiological studies of cognition, emotion, language, and other aspects of brain and behavior in human research participants with neurodevelopmental disorders that create IDD.

加州大学戴维斯分校 MIND 研究所 IDDRC 神经行为分析核心 (NAC) 的主要目标是帮助研究人员生成具有智力和智力的个体的详细表型特征发育障碍（IDD）。表型表征需要适合的措施 IDD 个体的代表性样本，并采用最先进的方法进行设计、执行和分析。精度和保真度成为可能。现有的标准化测试、评级量表和检查表往往不够充分为此，需要对此类措施进行描述和调整，或者制定新的措施。此外，许多措施往往仅适用于 IDD 人群中的一小部分。兴趣。 NAC 将协助 IDDRC 调查人员确保他们采取必要措施来生成先进的生物行为特征可以独立用于评估环境贡献 IDD，或为 IDD 靶向治疗的开发和评估提供证据基础。到为了实现这一目标，NAC 将利用跨学科的专业知识和已经制定的措施多名 MIND 研究所和加州大学戴维斯分校的教职员工为研究人员提供关键服务人类认知、情感、语言以及大脑和行为的其他方面的神经生物学研究患有导致 IDD 的神经发育障碍的研究参与者。