Site-specific delivery of photosensitizer and singlet oxygen in vivo

体内光敏剂和单线态氧的位点特异性递送

基本信息

批准号：
8474786
负责人：
ALEXANDER GREER
金额：
$ 37.5万
依托单位：
BROOKLYN COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-21 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8474786
关键词：
Area Blood Vessels Brain Brain Neoplasms Carotid Arteries Chemistry Cleaved cell Clinical Collaborations Complex Data Development Device or Instrument Development Devices Discipline Disease Drug Delivery Systems Engineering Eye Faculty Fiber Fiber Optics Funding Glass Goals Hybrids Hypoxia In Vitro Malignant neoplasm of esophagus Malignant neoplasm of ovary Medical Methods Modeling Operative Surgical Procedures Optics Organ Organic Chemistry Pharmaceutical Preparations Photochemotherapy Photosensitizing Agents Prodrugs Reaction Research Singlet Oxygen Site Skin Cancer Solutions System Technology Tissues Work aqueous base cancer therapy cytotoxic design expectation experience human disease improved in vivo innovation light intensity medical schools neoplastic cell new technology optical fiber photonics pre-clinical public health relevance targeted delivery treatment strategy tumor

项目摘要

DESCRIPTION (provided by applicant): Many clinical examples exist which require the use of a high-precision technology to eradicate tumors that are located next to vital anatomical sites. Sites that are often inaccessible or unsafe for treatment by traditional surgical and medical methods include major blood vessels such as the carotid arteries, critical areas of the brain, and portions of the eye. We will develop a site-specific fiber optic-based singlet oxygen generator, which has the potential to be used as a precise photochemical surgical knife to destroy tumor cells in areas that require cytotoxic control and are inaccessible by surgical methods. A fiber optic-based singlet oxygen generator for targeted singlet oxygen delivery is proposed for use in photodynamic therapy and drug delivery. The objective is to design a heterogeneous photodynamic therapy device that uses the optical excitation of sensitizer molecules released from porous ends on hollow photonic band-gap optical fibers through which O2 flows. The proposed research is predicated upon our strong preliminary data showing that porous Vycor glass serves as a photosensitizer support and can be integrated to a hollow fiber optic that is effective in generating singlet oxygen in aqueous solution. The hypothesis is that sensitizer molecules released from the fiber optic device will be localized at a tumor site and that high concentrations of singlet oxygen will be produced for its destruction at that site. This project is innovative in that, to date, all photodynamic therapy strategies have involved the systemic administration of a sensitizer; our work would therefore be the first to cleave a photosensitizer from the end of a fiber optic device through which O2 flows. The improved singlet oxygen delivery and selectivity is expected to fill a new niche in preclinical photodynamic therapy.

描述（由申请人提供）：存在许多临床实例，需要使用高精度技术来根除位于重要解剖部位附近的肿瘤。传统手术和医疗方法通常无法到达或不安全的部位包括颈动脉等主要血管、大脑的关键区域和眼睛的部分区域。我们将开发一种基于光纤的特定位点单线态氧发生器，它有潜力用作精确的光化学手术刀，以破坏需要细胞毒性控制且通过手术方法无法到达的区域的肿瘤细胞。提出了一种用于靶向单线态氧输送的基于光纤的单线态氧发生器，用于光动力疗法和药物输送。目的是设计一种异质光动力治疗装置，该装置利用从 O2 流过的空心光子带隙光纤上的多孔端释放的敏化剂分子的光激发。拟议的研究基于我们强有力的初步数据，该数据表明多孔 Vycor 玻璃可用作光敏剂载体，并且可以集成到中空光纤中，该中空光纤可有效在水溶液中产生单线态氧。假设从光纤装置释放的敏化剂分子将定位在肿瘤部位，并且将在该部位产生高浓度的单线态氧以将其破坏。该项目的创新之处在于，迄今为止，所有光动力治疗策略都涉及敏化剂的全身给药；因此，我们的工作将是第一个从氧气流经的光纤装置末端切割光敏剂的工作。改进的单线态氧输送和选择性有望填补临床前光动力治疗的新领域。

项目成果

期刊论文数量（28）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Synthesis and antiproliferative properties of a new ceramide analog of varacin.

新型伐拉辛神经酰胺类似物的合成和抗增殖特性。

DOI：
10.1016/j.chemphyslip.2015.07.023
发表时间：
2016
期刊：
Chemistry and physics of lipids
影响因子：
3.4
作者：
Mahendran,Adaickapillai;Ghogare,AshwiniA;Bittman,Robert;Arthur,Gilbert;Greer,Alexander
通讯作者：
Greer,Alexander

Encapsulation and convex-face thiozonolysis of triatomic sulfur (S(3)) with carbon nanotubes.