Acupuncture Trialists' Collaboration: meta-analysis of chronic pain trials

针灸试验者的合作：慢性疼痛试验的荟萃分析

• 批准号: 8474697
• 负责人: Andrew J Vickers
• 金额: $ 30.43万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8474697
• 关键词: Acupuncture Therapy; Acupuncture procedure; Address; Affect; Award; Back Pain; Characteristics; Chronic Headaches; Clinical; Clinical assessments; Collaborations; Control Groups; Data; Data Analyses; Data Set; Databases; Degenerative polyarthritis; Devices; Effectiveness; Eligibility Determination; Funding; Future; Grant; Headache; Heterogeneity; Individual; International; Meta-Analysis; Names; National Center for Complementary and Alternative Medicine; Neck Pain; Needles; Outcome; Pain; Patients; Penetration; Pharmaceutical Preparations; Pharmacotherapy; Physicians; Publications; Publishing; Randomized; Research; Research Design; Shoulder Pain; Specialist; Techniques; Time; Update; Work; chronic pain; experience; meetings; randomized trial; text searching

DESCRIPTION (provided by applicant): Acupuncture is often considered for the treatment of chronic pain, but its value remains controversial. The Acupuncture Trialists' Collaboration was established in 2006 to provide best evidence on the effects of acupuncture on chronic pain. The collaboration obtains individual patient level data from high quality randomized trials of acupuncture for chronic pain, standardizes the data in order to combine it in a single data set, and then conducts analyses t to address questions concerning both acupuncture effectiveness and acupuncture study design. NCCAM awarded the collaboration R21 funding in support of its work in 2008. The Acupuncture Trialists' Collaboration now consists of an international group of 31 physicians, clinical trialists, biostatisticians, practicing acupuncturists and other specialists including many of the most widely recognized names in acupuncture research. It has been extremely successful in obtaining raw data from trialists in the pain conditions under its remit: osteoarthritis, non- specific back and neck pain, chronic headache, and shoulder pain. Of the 31 trials that met the stringent eligibility criteria for inclusion in the collaboration data set, usable individual patient data have been obtained from 29 trials. Data from all 29 trials have been checked, relabeled and added to the collaboration database, which now includes nearly 18,000 randomized patients. The initial analyses of these data are complete. In particular, we found strong evidence that acupuncture is superior both to no acupuncture control and to sham acupuncture for each of the pain conditions included. We also found evidence that the effect size of acupuncture depended on the comparator, for example, there were smaller differences between true acupuncture and sham techniques involving needle penetration, than between true acupuncture and a non-penetrating sham device. The Acupuncture Trialists' Collaboration therefore has a proven track record of bringing high-impact acupuncture research to fruition. Here we propose to update our database of trials, and analyses thereof, with an additional 5 years of data. Continuation funding for the collaboration will also allow us to extend our analyses to comparisons of acupuncture with drug therapy and to address four additional questions pertaining to acupuncture: predictors of acupuncture benefit; the time course of acupuncture effects; whether there are acupuncture 'responders' that have exceptional improvements after acupuncture therapy; whether outcomes vary between practitioners.

描述（由申请人提供）：针灸通常是用于治疗慢性疼痛的，但其价值仍然有争议。针灸审判者的合作成立于2006年，目的是提供有关针灸对慢性疼痛的影响的最佳证据。该协作从针灸的高质量随机试验中获得了单个患者级别的数据，标准化数据以将其结合在单个数据集中，然后进行分析，以解决有关针灸有效性和针灸研究设计的问题。 NCCAM授予合作R21资金，以支持2008年的工作。针灸试验员的合作现在由31名医师，临床试验员，生物统计学家，实践针灸师和其他专家组成的国际团体组成，包括针刺研究中许多知名的名字。在疼痛条件下，在疼痛状况下从试验者那里获得原始数据非常成功：骨关节炎，非特异性背部和颈部疼痛，慢性头痛和肩痛。在符合严格资格标准的31项试验中，可以从29项试验中获得可用的个人患者数据。所有29个试验的数据都已检查，重新标记并添加到协作数据库中，该数据库现在包括近18,000名随机患者。这些数据的初步分析已完成。特别是，我们发现有力的证据表明，针灸既优于无针灸控制，又是对所包括的每种疼痛条件的假针刺。我们还发现证据表明，针灸的效果大小取决于比较器，例如，涉及针刺穿透的真实针灸和假手术技术之间的差异要小，而不是真正的针灸和非穿透性假手术装置之间的差异。因此，针灸审判员的合作具有使高影响力针灸研究实现的可靠记录。在这里，我们建议更新我们的试验数据库及其分析，并提供5年的数据。对合作的持续资金还将使我们能够将分析扩展到针灸与药物治疗的比较，并解决与针灸有关的其他四个问题：针灸益处的预测指标；针灸效应的时间过程；针灸治疗后是否有针灸的“反应者”；从业者之间的结果是否有所不同。