Integrated Treatment for Smoking Cessation & Anxiety in People with HIV

戒烟综合治疗

基本信息

项目摘要

DESCRIPTION (provided by applicant): Cigarette smoking is the leading cause of death and disability in the United States (U.S.), contributing to over 440,000 deaths each year. Still, over 40 million adults in the U.S. currently smoke despite well-established links to morbidity and mortality. Studies suggest HIV+ adults are at a higher risk for being current smokers and that quitting smoking may be particularly difficult for individuals with anxiety problems. Although panic and related anxiety disorders frequently co-occur with smoking and are prevalent among persons living with HIV, there has been very little attention given to improving cessation outcome among this high-risk group of HIV+ smokers. This neglect sits on the backdrop of a larger issue in the smoking cessation literature: a general lack of innovation in efficacious psychosocial treatments for nicotine dependence, particularly among persons living with HIV. Researchers have frequently called attention to the links across smoking and anxiety-related states. Recent evidence suggests that anxiety disorders and related anxiety vulnerability factors, specifically anxiety sensitivity (or fear of somatic arousal), negatively impact cessation. These findings indicate that there is clinical and theoretical merit to targeting anxiety symptoms among HIV+ smokers to improve cessation outcomes. A growing body of work suggests that anxiety disorders can be effectively treated with transdiagnostic cognitive behavioral treatment (CBT). Accordingly, we are proposing a 3-year study to develop an integrated treatment for smoking cessation for anxiety-vulnerable HIV+ smokers. The intervention development approach will follow a staged model consistent with NIH guidelines for developing and standardizing behavioral interventions, with the proposed research representing a Stage IB study. Specifically, during the first year, startup activities will include piloting the integrated intervention on a subset of individuals (N = 12), soliciting internal and external expert consultant and participant feedback, and development of the final treatment manual and procedures. The goal during this phase will be to establish feasibility of treatment delivery, participant acceptability, and potential for an effect. During the following two years, a small two-arm efficacy study (N = 60) will be undertaken comparing the new intervention to a control intervention. This study represents an important step in the larger landscape of translating basic research to more efficacious strategies for treating nicotine dependence in HIV. This study addresses an important public health issue by assessing an intervention that may lead to a more effective application for the treatment of at-risk HIV+ smokers. The expected findings should: (1) Guide advances in the theoretical conceptualization of the mechanisms involved in HIV-anxiety-smoking relations. (2) Directly inform the development of a novel and psychosocial/behavioral and pharmacological smoking cessation intervention(s) for HIV+ smokers with anxiety disorders. This is an interdisciplinary research proposal that involves collaboration between clinical psychologists, physicians, and mental health/HIV counselors.
描述(由申请人提供):吸烟是美国(美国)死亡和残疾的主要原因,每年造成超过440,000人死亡。尽管如此,尽管与发病率和死亡率有良好的联系,但目前在美国有超过4000万成年人吸烟。研究表明,艾滋病毒+成年人患有当前吸烟者的风险更高,对于患有焦虑问题的人来说,戒烟可能特别困难。尽管恐慌和相关的焦虑症经常与吸烟同时发生,并且在艾滋病毒感染者中普遍存在,但在这一高风险的HIV+吸烟者中,人们对改善停止结果的关注很少。这种忽视是在戒烟文献中较大问题的背景下:普遍缺乏对尼古丁依赖性的有效的社会心理治疗,尤其是在患有艾滋病毒的人中。研究人员经常呼吁人们注意吸烟和与焦虑有关的状态之间的联系。最近的证据表明,焦虑症和相关的焦虑脆弱性因素,特别是焦虑敏感性(或对躯体唤醒的恐惧),对停止产生了负面影响。这些发现表明,靶向艾滋病毒+吸烟者中焦虑症状以改善停止结果具有临床和理论优点。越来越多的工作表明,可以通过转诊性认知行为治疗(CBT)有效治疗焦虑症。 因此,我们提出了一项为期3年的研究,以开发一种综合治疗方法,用于戒烟,以缓解焦虑症的HIV+吸烟者。干预开发方法将遵循与NIH制定和标准化行为干预指南一致的分阶段模型,拟议的研究代表了IB阶段的研究。具体而言,在第一年,启动活动将包括对个人的一部分(n = 12)进行综合干预,征集内部和外部专家顾问以及参与者的反馈,以及开发最终的治疗手册和程序。在此阶段的目标是确定治疗交付,参与者的可接受性和效果的潜力的可行性。在接下来的两年中,将进行一项小型的两臂疗效研究(n = 60),将新干预与对照干预进行比较。这项研究代表了将基础研究转化为更有效治疗HIV中尼古丁依赖性的更有效策略的更大景观的重要一步。 这项研究通过评估一种干预措施来解决一个重要的公共卫生问题,该干预措施可能会导致对处于危险的HIV+吸烟者的治疗更有效。预期的发现应:(1)指导在艾滋病毒 - 焦虑探索关系中涉及的机制的理论概念化方面的进步。 (2)直接为患有焦虑症的艾滋病毒+吸烟者的新颖和社会心理/行为和药理学戒烟干预提供了信息。这是一项跨学科研究建议,涉及临床心理学家,医生和心理健康/HIV辅导员之间的合作。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Moderate levels of depression predict sexual transmission risk in HIV-infected MSM: a longitudinal analysis of data from six sites involved in a "prevention for positives" study.
  • DOI:
    10.1007/s10461-013-0462-8
  • 发表时间:
    2013-06
  • 期刊:
  • 影响因子:
    4.4
  • 作者:
    O'Cleirigh, Conall;Newcomb, Michael E.;Mayer, Kenneth H.;Skeer, Margie;Traeger, Lara;Safren, Steven A.
  • 通讯作者:
    Safren, Steven A.
Characteristics and Correlates of Tobacco Use in a Community Sample of Sexual Minority Men and Women: Implications for Smoking Cessation Program Development.
性少数群体男性和女性社区样本中烟草使用的特征和相关性:对戒烟计划制定的影响。
  • DOI:
    10.1089/lgbt.2016.0157
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    4.8
  • 作者:
    O'Cleirigh,Conall;Elsesser,StevenA;King,Dana;Ehlinger,PeterP;Bradford,JudithB;Grasso,Chris;Mayer,KennethH
  • 通讯作者:
    Mayer,KennethH
A qualitative study of the feasibility and acceptability of a smoking cessation program for people living with HIV and emotional dysregulation.
  • DOI:
    10.1080/09540121.2018.1533225
  • 发表时间:
    2019-05
  • 期刊:
  • 影响因子:
    1.7
  • 作者:
    Labbe AK;Wilner JG;Coleman JN;Marquez SM;Kosiba JD;Zvolensky MJ;Smits JAJ;Norton PJ;Rosenfield D;O'Cleirigh C
  • 通讯作者:
    O'Cleirigh C
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Conall Michael O'Cleirigh其他文献

Conall Michael O'Cleirigh的其他文献

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{{ truncateString('Conall Michael O'Cleirigh', 18)}}的其他基金

Treatment Development for Smoking Cessation and Engagement in HIV/TB Care in South Africa
南非戒烟和参与艾滋病毒/结核病护理的治疗方法开发
  • 批准号:
    10706874
  • 财政年份:
    2023
  • 资助金额:
    $ 24.53万
  • 项目类别:
Effectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/Depression in People Living with HIV
解决艾滋病毒感染者戒烟和焦虑/抑郁问题的综合治疗的有效性
  • 批准号:
    10400306
  • 财政年份:
    2021
  • 资助金额:
    $ 24.53万
  • 项目类别:
Effectivenss of an Integrated Treatment to Address Smoking Cessation and Anxiety/Depression in People Living with HIV
综合治疗解决艾滋病毒感染者戒烟和焦虑/抑郁问题的有效性
  • 批准号:
    10349475
  • 财政年份:
    2019
  • 资助金额:
    $ 24.53万
  • 项目类别:
Effectivenss of an Integrated Treatment to Address Smoking Cessation and Anxiety/Depression in People Living with HIV
综合治疗解决艾滋病毒感染者戒烟和焦虑/抑郁问题的有效性
  • 批准号:
    9925766
  • 财政年份:
    2019
  • 资助金额:
    $ 24.53万
  • 项目类别:
Effectivenss of an Integrated Treatment to Address Smoking Cessation and Anxiety/Depression in People Living with HIV
综合治疗解决艾滋病毒感染者戒烟和焦虑/抑郁问题的有效性
  • 批准号:
    9926444
  • 财政年份:
    2019
  • 资助金额:
    $ 24.53万
  • 项目类别:
Nurse-Delivered CBT for Depression-Adherence in HIV Primary Care S. Africa
护士为南非艾滋病毒初级保健中的抑郁症依从性提供 CBT
  • 批准号:
    9127808
  • 财政年份:
    2015
  • 资助金额:
    $ 24.53万
  • 项目类别:
Nurse-Delivered CBT for Depression-Adherence in HIV Primary Care S. Africa
护士为南非艾滋病毒初级保健中的抑郁症依从性提供 CBT
  • 批准号:
    8991805
  • 财政年份:
    2015
  • 资助金额:
    $ 24.53万
  • 项目类别:
Integrated Behavioral Treatment for Chronic Pain/Drug Use in Older MSM with HIV
针对老年 HIV 感染男男性行为者的慢性疼痛/药物使用的综合行为治疗
  • 批准号:
    9000143
  • 财政年份:
    2015
  • 资助金额:
    $ 24.53万
  • 项目类别:
Integrated Treatment for Smoking Cessation & Anxiety in People with HIV
戒烟综合治疗
  • 批准号:
    8209316
  • 财政年份:
    2011
  • 资助金额:
    $ 24.53万
  • 项目类别:
HIV Prevention and Trauma Treatment for MSM with Childhood Sexual Abuse Histories
有童年性虐待史的 MSM 的艾滋病毒预防和创伤治疗
  • 批准号:
    8664432
  • 财政年份:
    2011
  • 资助金额:
    $ 24.53万
  • 项目类别:

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促炎细胞因子、有害酒精使用和脑代谢物的纵向建模作为 HIV 感染者神经认知变化的预测因子
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Assessing the real-world impact of a low nicotine product standard for smoked tobacco in New Zealand
评估新西兰低尼古丁产品标准对吸食烟草的现实影响
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以运动为基础的戒烟治疗对高焦虑敏感性成人的疗效和实施
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提高吸烟治疗利用率和戒烟的退伍军人社会支持干预
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