Imaging the Effect of rTMS on Brain Activity in Cocaine Abusers

成像 rTMS 对可卡因滥用者大脑活动的影响

• 批准号: 8531203
• 负责人: Diana M Martinez
• 金额: $ 19.18万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8531203
• 关键词: Affect; Animal Model; Anterior; Area; Asses; Award; Basic Science; Behavior; Behavioral; Blood; Blood flow; Brain; Brain region; Clinical; Clinical Research; Clinical Treatment; Clinical Trials; Cocaine; Cocaine Abuse; Cocaine Dependence; Color; Data; Dependence; Frequencies; Functional Imaging; Functional Magnetic Resonance Imaging; Future; Goals; Human; Image; Laboratories; Magnetic Resonance Imaging; Measures; Medial; Metabolic; Metabolism; Methods; Modeling; Mood Disorders; Neurobiology; Neurotransmitters; Oxygen; Pharmaceutical Preparations; Play; Positron-Emission Tomography; Prefrontal Cortex; Randomized; Relapse; Research Priority; Role; Safety; Scanning; Self Administration; Self-Administered; Structure; System; Testing; Therapeutic; Thinking; Transcranial magnetic stimulation; Treatment outcome; Work; addiction; blood oxygen level dependent; cocaine use; design; fluorodeoxyglucose; frontal lobe; glucose metabolism; glucose uptake; high risk; human subject; innovation; innovative technologies; instrument; novel; reinforcer; repetitive transcranial magnetic stimulation; response

DESCRIPTION (provided by applicant): Treatment for cocaine dependence is a research priority, and innovative treatment approaches are needed. The goal of this application is to investigate the potential of a innovative technology that targets a brain region, rather than a medication, for cocaine abuse. Using a repetitive transcranial magnetic stimulation (rTMS) with a newly developed coil that can reach deeper brain regions (the H1 coil), this proposed application will study the effects of deep rTMS directed at the dorsomedial prefrontal cortex and anterior cingulate. Cocaine abusing subjects will undergo functional imaging studies using Positron Emission Tomography (PET) and Magnetic Resonance Imaging (fMRI). The PET scans will use [18F]FDG to measure regional glucose uptake and the fMRI scans will image the effect of deep rTMS on the blood-oxygen-level dependence response to the color-word stroop task. In addition to imaging, a laboratory model of relapse will be used, in which non-treatment seeking cocaine abusing subjects participate in cocaine self-administration sessions. In this model, cocaine abusing subjects are given the choice to self-administer cocaine in the setting of an alternative reinforcer (money), and the hypothesis is that brain stimulation will reduce cocaine self- administration. While this study is not a clinical trail for rTMS, it uses innovative methods that can provide a rapid assessment of its therapeutic potential. This type of translational work can be performed much more rapidly than a clinical study, in addition to providing information on the mechanism behind the response.

描述（由申请人提供）：可卡因依赖的治疗是研究重点，需要创新的治疗方法。该应用程序的目标是研究针对可卡因滥用的大脑区域而不是药物的创新技术的潜力。这项拟议的应用将使用重复经颅磁刺激 (rTMS) 和新开发的可到达更深层大脑区域（H1 线圈）的线圈，研究深度 rTMS 针对背内侧前额叶皮层和前扣带皮层的影响。可卡因滥用者将使用正电子发射断层扫描 (PET) 和磁共振成像 (fMRI) 进行功能成像研究。 PET 扫描将使用 [18F]FDG 来测量区域葡萄糖摄取，fMRI 扫描将成像深度 rTMS 对色词 stroop 任务的血氧水平依赖性反应的影响。除了成像之外，还将使用复发的实验室模型，其中未寻求治疗的可卡因滥用受试者参加可卡因自我给药课程。在该模型中，可卡因滥用受试者可以选择在替代强化物（金钱）的情况下自我施用可卡因，并且假设大脑刺激将减少可卡因自我施用。虽然这项研究不是 rTMS 的临床试验，但它使用了创新的 可以快速评估其治疗潜力的方法。除了提供有关反应背后机制的信息之外，这种类型的转化工作可以比临床研究更快地进行。