Imaging the Effect of rTMS on Brain Activity in Cocaine Abusers

成像 rTMS 对可卡因滥用者大脑活动的影响

基本信息

批准号：
8531203
负责人：
Diana M Martinez
金额：
$ 19.18万
依托单位：
NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8531203
关键词：
Affect Animal Model Anterior Area Asses Award Basic Science Behavior Behavioral Blood Blood flow Brain Brain region Clinical Clinical Research Clinical Treatment Clinical Trials Cocaine Cocaine Abuse Cocaine Dependence Color Data Dependence Frequencies Functional Imaging Functional Magnetic Resonance Imaging Future Goals Human Image Laboratories Magnetic Resonance Imaging Measures Medial Metabolic Metabolism Methods Modeling Mood Disorders Neurobiology Neurotransmitters Oxygen Pharmaceutical Preparations Play Positron-Emission Tomography Prefrontal Cortex Randomized Relapse Research Priority Role Safety Scanning Self Administration Self-Administered Structure System Testing Therapeutic Thinking Transcranial magnetic stimulation Treatment outcome Work addiction blood oxygen level dependent cocaine use design fluorodeoxyglucose frontal lobe glucose metabolism glucose uptake high risk human subject innovation innovative technologies instrument novel reinforcer repetitive transcranial magnetic stimulation response

项目摘要

DESCRIPTION (provided by applicant): Treatment for cocaine dependence is a research priority, and innovative treatment approaches are needed. The goal of this application is to investigate the potential of a innovative technology that targets a brain region, rather than a medication, for cocaine abuse. Using a repetitive transcranial magnetic stimulation (rTMS) with a newly developed coil that can reach deeper brain regions (the H1 coil), this proposed application will study the effects of deep rTMS directed at the dorsomedial prefrontal cortex and anterior cingulate. Cocaine abusing subjects will undergo functional imaging studies using Positron Emission Tomography (PET) and Magnetic Resonance Imaging (fMRI). The PET scans will use [18F]FDG to measure regional glucose uptake and the fMRI scans will image the effect of deep rTMS on the blood-oxygen-level dependence response to the color-word stroop task. In addition to imaging, a laboratory model of relapse will be used, in which non-treatment seeking cocaine abusing subjects participate in cocaine self-administration sessions. In this model, cocaine abusing subjects are given the choice to self-administer cocaine in the setting of an alternative reinforcer (money), and the hypothesis is that brain stimulation will reduce cocaine self- administration. While this study is not a clinical trail for rTMS, it uses innovative methods that can provide a rapid assessment of its therapeutic potential. This type of translational work can be performed much more rapidly than a clinical study, in addition to providing information on the mechanism behind the response.

描述（由申请人提供）：可卡因依赖的治疗是研究的重点，需要创新的治疗方法。该应用程序的目的是研究针对大脑区域而不是药物来滥用可卡因的创新技术的潜力。使用重复的经颅磁刺激（RTMS）与新开发的线圈，该线圈可以到达更深的大脑区域（H1线圈），该提出的应用将研究针对背侧前额叶皮层和前侧收益的深RTM的影响。可卡因滥用受试者将使用正电子发射断层扫描（PET）和磁共振成像（fMRI）进行功能成像研究。 PET扫描将使用[18F] FDG测量区域葡萄糖的吸收，而fMRI扫描将对深RTMS对血氧级级别依赖性响应的影响对颜色词的Stroop任务产生影响。除成像外，还将使用复发的实验室模型，在该模型中，寻求可卡因虐待受试者的非治疗参与可卡因自我管理会议。在此模型中，可卡因滥用受试者可以选择在替代增强器（货币）的情况下自我管理可卡因，并且假设是大脑刺激会减少可卡因的自我给药。虽然这项研究不是RTMS的临床步道，但它使用创新可以快速评估其治疗潜力的方法。除了提供有关反应背后的机制的信息外，这种类型的翻译工作可以比临床研究更快地进行。