Imaging the Effect of Deep rTMS on Brain Activity in Chronic Cannabis Use

深度 rTMS 对长期吸食大麻时大脑活动的影响成像

基本信息

批准号：
8584100
负责人：
Nina Beatrix Lieselotte Urban
金额：
$ 23.97万
依托单位：
NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8584100
关键词：
Abstinence Acetylcysteine Acute Affect Agonist Anterior Area Behavior Brain Brain region Cannabinoids Cannabis Cannabis Abuse Chronic Clinical Trials Cocaine Cognition Cognitive Color Conflict (Psychology)Data Deep Brain Stimulation Drug Addiction Electromagnetics Frequencies Functional Imaging Functional Magnetic Resonance Imaging Future Goals Human Human Volunteers Illicit Drugs Image Inpatients Laboratories Lead Magnetic Resonance Imaging Marijuana Marijuana Dependence Matched Group Measures Medial Methods Modeling Names Participant Performance Pharmaceutical Preparations Placebos Preclinical Drug Evaluation Prefrontal Cortex Prevalence Randomized Relapse Research Project Grants Research Proposals Response to stimulus physiology Rest Self Administration Self-Administered Severities Short-Term Memory Structure Substance Withdrawal Syndrome Task Performances Testing Tetrahydrocannabinol Time Tobacco United States Verbal Learning Withdrawal Withdrawal Symptom addiction alternative treatment base blood oxygen level dependent clinically relevant design drug craving drug of abuse experience flexibility follow-up functional disability human subject imaging probe improved innovation neuropsychological novel prevent processing speed public health relevance repetitive transcranial magnetic stimulation response rimonabant volunteer

项目摘要

DESCRIPTION (provided by applicant): The objective of this research proposal is to use functional magnetic resonance imaging (fMRI) and a laboratory model of cannabis self-administration to evaluate an innovative type of repetitive transcranial magnetic stimulation (rTMS) in human volunteers as a potential treatment approach to cannabis dependence. There is preliminary evidence that rTMS with standard coils applied to the dorsolateral prefrontal cortex in cocaine and tobacco users reduce drug craving and drug self-administration. This study proposes to use rTMS with the H1 coil, which allows for the stimulation of deeper brain structures than previously available. The H1 coil will be directed at the dorsomedial prefrontal cortex (PFC) and anterior cingulate (ACC), areas shown to be affected in addiction, including cannabis dependence. Using fMRI and the Stroop color-naming task, we will compare baseline BOLD activation in the PFC and ACC of abstinent (but not treatment-seeking) chronic cannabis users and control subjects. The Stroop task assesses response to conflicting stimuli and response inhibition, functions subserved by the ACC and DLPFC. Cannabis using subjects will be randomized to receive active vs. sham rTMS for 11 days. We will repeat fMRI to measure any changes in BOLD activation in the PFC and ACC resulting from active rTMS administration, compared to sham. In addition, a laboratory model of cannabis seeking behavior will be used to investigate the potential of rTMS to reduce cannabis self-administration in human subjects. Laboratory based self-administration sessions can provide a model of withdrawal and relapse, and can be used to evaluate potential treatments for drug dependence. The overall hypothesis is that active rTMS administration will increase activity in the PFC and ACC and reduce the choice the self-administer cannabis. The results from this study will provide important pilot- data for a future larger study using this novel method as an imaging probe and as a potential treatment for cannabis abuse and dependence.

描述（由申请人提供）：本研究提案的目的是使用功能磁共振成像（fMRI）和大麻自我管理实验室模型来评估人类志愿者的创新型重复经颅磁刺激（rTMS）作为大麻依赖的潜在治疗方法。初步证据表明，将带有标准线圈的 rTMS 应用于可卡因和烟草使用者的背外侧前额皮质，可减少药物渴望和药物自我给药。这项研究建议将 rTMS 与 H1 线圈结合使用，这样可以刺激比以前更深的大脑结构。 H1 线圈将针对背内侧前额叶皮层 (PFC) 和前扣带皮层 (ACC)，这些区域被证明会受到成瘾（包括大麻依赖）的影响。使用 fMRI 和 Stroop 颜色命名任务，我们将比较戒断（但不寻求治疗）慢性大麻使用者和对照受试者的 PFC 和 ACC 中的基线 BOLD 激活。 Stroop 任务评估对冲突刺激的反应和反应抑制，以及 ACC 和 DLPFC 所支持的功能。使用大麻的受试者将被随机分配接受活性 rTMS 与假 rTMS，为期 11 天。我们将重复功能磁共振成像来测量与假手术相比，主动 rTMS 给药导致的 PFC 和 ACC 中 BOLD 激活的任何变化。此外，大麻寻求行为的实验室模型将用于研究 rTMS 减少人类受试者自我服用大麻的潜力。基于实验室的自我给药课程可以提供戒断和复发的模型，并可用于评估药物依赖的潜在治疗方法。总体假设是，主动 rTMS 给药会增加 PFC 和 ACC 的活动，并减少自我给药大麻的选择。这项研究的结果将提供重要的试点数据未来进行更大规模的研究，使用这种新方法作为成像探针，并作为大麻滥用和依赖的潜在治疗方法。