Pediatric Heart network DCC

儿科心脏网络 DCC

基本信息

批准号：
8182526
负责人：
LYNN A SLEEPER
金额：
$ 892.35万
依托单位：
NEW ENGLAND RESEARCH INSTITUTES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-06 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8182526
关键词：
Address Adherence Adolescent Adrenergic beta-Antagonists Adverse event Age Arrhythmia Aspirin Atenolol Bioinformatics Books Budgets Cardiology Cardiomyopathies Cardiovascular system Caring Case Report Form Certification Cessation of life Child Childhood Clinical Clinical Data Clinical Management Clinical Research Clinical Treatment Clinical Trials Code Cohort Studies Collaborations Common Ventricle Communication Congenital Heart Defects Contracts Core Facility Coronary artery Data Data Coordinating Center Data Quality Data Set Databases Development Devices Diagnostic Dictionary Dimensions Disease Documentation EFRAC Electronics Enalapril Enrollment Event Evidence Based Medicine Exercise Fostering Funding Genetic Goals Growth Health Health Status Heart Heart Diseases Image Infant Inflammatory Information Systems Institution Intravenous Immunoglobulins Journals Laboratories Lead Leadership Losartan Magnetic Resonance Imaging Maintenance Manuals Manuscripts Marfan Syndrome Measurement Measures Medical Medical center Methylprednisolone Mission Monitor Multi-Institutional Clinical Trial Myocardium Myopathy National Heart, Lung, and Blood Institute New England Observational Study Occupational activity of managing finances Online Systems Operative Surgical Procedures Outcome Parents Performance Persons Pharmaceutical Preparations Physiologic pulse Placebos Plant Roots Play Policies Positioning Attribute Preparation Principal Investigator Procedures Process Production Program Development Protocols documentation Publications Publishing Pulmonary artery structure Quality Control Quality of life Randomized Reading Registries Reporting Research Research Design Research Infrastructure Research Institute Research Personnel Research Support Resources Role Safety Sample Size Schedule Science Scientist Secure Serologic tests Services Shunt Device Site Steroids System Teleconferences Testing Time Training Translational Research Transplantation Ventricular Visit Weight Work Writing biobank clinical research site congenital heart disorder cost data acquisition data exchange data sharing design distributed data experience follow-up high standard improved innovation meetings novel operation payment programs protocol development quality assurance racial and ethnic disparities randomized trial reconstruction repository research study statistics symposium tool web site young adult

项目摘要

DESCRIPTION (provided by applicant): New England Research Institutes, Inc. (NERI) is applying to continue its 10-year role as the Data Coordinating Center (DCC) for the Pediatric Heart Network (PHN). The PHN will continue as a cooperative network of up to 8 Clinical Centers, 15 auxiliary sites, a DCC, a Network Chair, and NHLBI Project Scientists. The objectives of the PHN are to 1) provide an infrastructure for multi-center collaborative clinical research, and 2) to evaluate diagnostic, medical, interventional, and surgical therapies for congenital heart defects, inflammatory heart disease, heart muscle disease, and arrhythmias. As the DCC, NERI will continue to provide scientific and logistical support for the next cycle of the Network, with key responsibilities and functions for leadership in study design and statistics, overall study coordination and management of data acquisition; leadership in development activities for bioinformatics infrastructure and tools; electronic information and data systems; logistical and support services; and management and distribution of Network funds. A multiple PI leadership plan is proposed to continue the leadership roles shared by Dr. Sleeper (Clinical and Statistical Science) and Dr. Tennstedt (Network Operations), with clearly delineated roles and responsibilities for leading and directing the DCC, intellectually and operationally. Importantly, the DCC staff will be organized to include a Network Manager who is also the Manager for the NHLBI Bench to Bassinet Program. This will position the DCC to facilitate integration of the PHN as the clinical trials component of the B2B Program. RELEVANCE: The mission of the Pediatric Heart Network is to improve the health and quality of life for children, adolescents, and young adults who are born with heart defects or develop heart disease by conducting large clinical studies at many medical centers. The Data Coordinating Center provides important services to guide and support this research.

描述（由申请人提供）：新英格兰研究机构 (NERI) 正在申请继续担任儿科心脏网络 (PHN) 数据协调中心 (DCC) 的 10 年职责。 PHN 将继续作为一个由多达 8 个临床中心、15 个辅助中心、一个 DCC、一名网络主席和 NHLBI 项目科学家组成的合作网络。 PHN 的目标是 1) 为多中心协作临床研究提供基础设施，2) 评估先天性心脏病、炎症性心脏病、心肌疾病和心律失常的诊断、医疗、介入和手术治疗。作为DCC，NERI将继续为网络的下一个周期提供科学和后勤支持，其主要职责和职能是领导研究设计和统计、整体研究协调和数据采集管理；领导生物信息学基础设施和工具的开发活动；电子信息和数据系统；后勤和支持服务；网络资金的管理和分配。提出了一项多重 PI 领导计划，以继续由 Sleeper 博士（临床和统计科学）和 Tennstedt 博士（网络运营）共同承担领导角色，并明确界定在智力和运营方面领导和指导 DCC 的角色和责任。重要的是，DCC 工作人员中将包括一名网络经理，他也是 NHLBI 长凳到摇篮计划的经理。这将使 DCC 能够促进 PHN 整合为 B2B 计划的临床试验组成部分。相关性：儿科心脏网络的使命是通过在许多医疗中心进行大型临床研究来改善患有先天性心脏缺陷或罹患心脏病的儿童、青少年和年轻人的健康和生活质量。数据协调中心提供重要服务来指导和支持这项研究。