Imaging

影像学

• 批准号: 8114899
• 负责人: DAVID S GIERADA
• 金额: $ 21.4万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8114899
• 关键词: Back; Chronic Obstructive Airway Disease; Clinical; Data; Development; Dimensions; Evaluation; Gases; Human; Image; Image Analysis; Imaging Techniques; Individual; Institution; Investigation; Lung; Lung volume reduction surgery; Magnetic Resonance Imaging; Measurement; Methodology; Methods; Pathologist; Patients; Performance; Procedures; Production; Protocols documentation; Pulmonary Emphysema; Scanning; Services; Specimen; Surgeon; Technical Expertise; Techniques; X-Ray Computed Tomography; attenuation; design and construction; experience; image archival system; image processing; image reconstruction; multidisciplinary; programs; radiologist

The Imaging Core will provide the scientific and technical expertise needed to fulfill all of the CT and MR imaging needs of the Projects. Providing all imaging services through a single core will avoid duplication of effort regarding Human Studies and regulatory issues, development of scanning protocols, subject management during scanning, and image analysis techniques. Image analysis methods will focus on the quantification of emphysema for both CT and MR, and also airway and airway wall dimensions with CT. Performing all procedures through a single Core will insure consistent imaging and analysis methodology among the Projects, facilitating comparison and correlation of imaging data. The Imaging Core will be comprised of individuals that have been part of a multidisciplinary team (which includes radiologists, physicists, pulmonologists, pathologists, and surgeons) involved in the CT and He MR evaluation of COPD that dates back over seven years. Our experience with the use of these imaging techniques began with the characterization of patients with severe COPD in the Lung Volume Reduction Surgery program at our institution (1-7). It has involved investigations into the impact of technical factors on CT measurements of lung attenuation (8-10), technical factors involved in 3He MR imaging (11-13), and evaluation of the lung microstructure with 3He MR (14). We have performed emphysema-related quantitative analysis of CT scans in over 200 patients, imaged more than 50 subjects with 3He MR (including 33 with advanced COPD), and imaged more than 30 explanted lung specimens with both CT and 3He MR in ongoing studies. Services provided by the Core will include: assistance with Human Studies and regulatory issues; development and implementation of scanning and image reconstruction protocols; production of hyperpolarized 3He gas for MR imaging; MR imaging coil design and construction; performance of CT and MR scans; clinical interpretation of CT scans; image processing and analysis; archiving of images and raw data; and assistance with image deidentification as needed. Project 1 will use the Imaging Core for CT and MR imaging, image analysis, and associated services. Project 3 will use the Core for CT imaging, image analysis, and associated services, and for analysis of existing CT scans of potential subjects for the presence emphysema. Projects 4 and 5 will use the Imaging Core for CT imaging, image analysis, and associated services.

成像核心将提供完成所有 CT 和诊断所需的科学和技术专业知识。 项目的 MR 成像需求。通过单个核心提供所有成像服务将避免重复 关于人类研究和监管问题、扫描协议的开发、主题的努力 扫描期间的管理和图像分析技术。图像分析方法将重点关注 CT 和 MR 定量肺气肿，以及 CT 定量气道和气道壁尺寸。 通过单个核心执行所有程序将确保一致的成像和分析方法 项目之间，促进成像数据的比较和关联。 成像核心将由多学科团队的成员组成 （包括放射科医生、物理学家、肺科医生、病理学家和外科医生）参与 CT 和 他对 COPD 的 MR 评估可以追溯到七年前。我们使用这些成像的经验 技术始于严重 COPD 患者肺容量减少的特征 我们机构的手术计划 (1-7)。涉及技术因素对CT影响的调查 肺衰减测量 (8-10)、3He MR 成像涉及的技术因素 (11-13) 和评估 使用 3He MR 观察肺微观结构 (14)。我们进行了肺气肿相关的定量分析 对 200 多名患者进行 CT 扫描，对 50 多名受试者进行 3He MR 成像（其中 33 名晚期患者） COPD），并在正在进行的研究中使用 CT 和 3He MR 对 30 多个外植肺标本进行了成像。 核心提供的服务将包括： 人类研究和监管问题方面的协助； 扫描和图像重建协议的开发和实施；生产 用于 MR 成像的超极化 3He 气体；磁共振成像线圈设计和构造； CT和MR表现 扫描； CT 扫描的临床解释；图像处理与分析；图像和原始数据的归档； 并根据需要提供图像去识别帮助。项目 1 将使用 CT 和 MR 成像核心 成像、图像分析和相关服务。项目 3 将使用 Core 进行 CT 成像、图像分析、 和相关服务，以及分析潜在受试者的现有 CT 扫描是否存在 气肿。项目 4 和 5 将使用 Imaging Core 进行 CT 成像、图像分析和相关 服务。