Self-regulatory Control and Eating: A Neuroimaging Study of Bulimia Nervosa

自我调节控制和饮食：神经性贪食症的神经影像学研究

• 批准号: 8457572
• 负责人: Laura A. Berner
• 金额: $ 4.22万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-04 至 2014-09-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8457572
• 关键词: Affect; Area; Base of the Brain; Behavior; Behavioral; Binge Eating; Brain; Bulimia; Chronic; Classification; Complement; Corpus striatum structure; Data; Development; Diagnostic; Diagnostic and Statistical Manual; Disease; Eating; Eating Disorders; Exhibits; Food; Frequencies; Functional Magnetic Resonance Imaging; Goals; Image; Impairment; Individual; Informal Social Control; Investigation; Link; Liquid substance; Maintenance; Measurement; Measures; Mediating; Mental disorders; Modality; Morphologic artifacts; Motion; National Research Service Awards; Near-Infrared Spectroscopy; Participant; Pathology; Patient Self-Report; Performance; Prefrontal Cortex; Process; Psychopathology; Reporting; Research; Research Training; Risk Factors; Self-control as a personality trait; Severities; Signal Transduction; Stimulus; Symptoms; System; Testing; Training Activity; Validation; Woman; Yogurt; base; behavior measurement; cognitive neuroscience; disorder prevention; experience; functional disability; improved; meetings; neurobehavioral; neuroimaging; neuromechanism; novel; programs; psychosocial; relating to nervous system; research study; response; skills; therapy development

DESCRIPTION (provided by applicant): There is considerable evidence to suggest that individuals with bulimia nervosa (BN) exhibit deficits in self- regulatory control. The brain regios involved in these processes have been identified by functional magnetic resonance imaging (fMRI) studies. However, research directly linking self-regulatory deficits and neural activity to clinically meaningful behaviors in BN is notably lacking, largely because motion artifact precludes measurement with fMRI of neural activity during participant-initiated eating. The proposed Ruth L. Kirschstein National Research Service Award (NRSA) is a two-year program of research and training focused on the neural systems mediating general and eating-related self-regulatory control processes in BN. Functional near- infrared spectroscopy (fNIR), a portable and inexpensive neuroimaging modality, allows for assessment of cortical activity in more ecologically- and clinically-valid settings. The proposed project will examine brain activity during a standard and an eating-related go/no-go task in 35 women meeting provisional DSM-5 diagnostic criteria for BN and 35 matched healthy controls. The project aims first to confirm and cross-validate previous findings. This will include testing the hypotheses that 1) compared to healthy controls, women with BN will demonstrate impaired performance and reduced prefrontal neural activity (as measured by fNIR) during the inhibition of prepotent responses in a standard go/no-go task; 2) among women with BN, the magnitude of activity in prefrontal regions will correlate inversely with self-reported frequency of bulimic behaviors. In a subset of participants (n = 28), the fNIR data for this standard task will be cross-validated using fMRI. The study then aims to extend findings using a novel, go/no-go liquid-meal sipping task and a palatable yogurt shake. The same hypotheses will be tested during this second go/no-go task, which requires inhibition of a prepotent sipping response during "no-go" trials. The results of the proposed study would not only confirm the importance of deficits in prefrontal activation during response inhibition tasks in BN, but extend these previous findings by demonstrating similar, and perhaps more profound, deficiencies in activity during a behavioral task that requires self-regulatory control during eating. Importantly, unlike previous studies that have included only symptom-provocation tasks or general cognitive neuroscience paradigms, the combination of aims allows for distinction of activations related specifically to the inhibition of eating from those related o general response inhibition. This NRSA will provide the applicant with the skills and research experience needed to integrate imaging and behavioral data in the investigation of the neural substrates of BN. The novel integration of neuroimaging with a cognitive neuroscience paradigm and an eating task will elucidate the neurobehavioral connections associated with binge eating and the prefrontal neural mechanisms that may contribute to the development and maintenance of the disorder. PUBLIC HEALTH RELEVANCE: While considerable evidence suggests that individuals with bulimia nervosa (BN) struggle with self-regulation, no research to date has directly linked brain activity, self-regulatory deficits, and clinically meaningful behaviors in this chronic and increasingly prevalent psychiatric disorder. The proposed study will be the first to measure brain activity among women with and without BN during both general and eating-related self-regulatory control tasks. The results will allow us to better determine whether altered activity in the prefrontal regions that mediate self-regulatory processes is specific to bulimic pathology.

描述（由申请人提供）：有大量证据表明，神经性贪食症（BN）的个体在自我调节控制方面表现出缺陷。通过功能磁共振成像（fMRI）研究鉴定了参与这些过程的大脑区域。但是，将自我调节性缺陷和神经活动与BN的临床有意义行为联系起来的研究显然缺乏，主要是因为运动伪像在参与者发起的饮食过程中无法通过神经活动的fMRI进行测量。拟议的露丝·柯希斯坦国家研究服务奖（NRSA）是一项为期两年的研究和培训计划，重点介绍了BN中介导一般和与饮食相关的自我调节性控制过程的神经系统。功能性近红外光谱（FNIR）是一种便携式且廉价的神经影像学模式，可以评估更生态和临床播种的环境中的皮质活动。拟议的项目将在标准和与饮食有关的GO/NO-GO任务期间检查大脑活动，其中35名妇女遇到了BN的临时DSM-5诊断标准和35个匹配的健康对照。该项目首先旨在确认和跨越验证以前的发现。这将包括检验1）与健康对照组相比的假设，在抑制标准的GO/NO-DO任务中，BN的女性将表现出表现受损的性能和降低前额叶神经活动（由FNIR衡量）； 2）在BN的女性中，前额叶区域的活性幅度将与自我报告的粗暴行为相关。在参与者的子集中（n = 28），该标准任务的FNIR数据将使用fMRI进行交叉验证。然后，该研究的目的是使用小说，GO/No-Go液体饮食任务和可口的酸奶奶昔扩展发现。在第二次执行/不执行任务中，将对同样的假设进行测试，这需要抑制在“禁止”试验期间进行预言的响应。拟议的研究的结果不仅会证实BN响应抑制任务期间前额叶激活中缺陷的重要性，而且还通过证明在行为任务中需要进行自我调节的行为任务中相似，更深刻的活动中的相似，更深刻的活动来扩展这些先前的发现。重要的是，与以前仅包括症状出现任务或一般认知神经科学范式的研究不同，目的的组合可以区分与从这些相关的一般反应抑制中抑制进食有关的激活。该NRSA将为申请人提供将成像和行为数据整合到BN神经基质中所需的技能和研究经验。神经影像与认知神经科学范式和饮食任务的新型整合将阐明与暴饮暴食有关的神经行为连接以及可能有助于该疾病发展和维持的前额叶神经机制。 公共卫生相关性：虽然有大量证据表明，神经性贪食症（BN）的人与自我调节作斗争，但迄今为止，没有研究直接联系大脑活动，自我调节性缺陷以及在这种慢性且越来越普遍的精神病患者中的临床意义。拟议的研究将是在一般和饮食相关的自我调节控制任务中首次测量有或没有BN的女性大脑活动的研究。结果将使我们能够更好地确定活动是否改变了 介导自我调节过程的前额叶区域特异性是粗糙的病理学。