Developmental Activities

发展活动

基本信息

批准号：
7983702
负责人：
ROBERT Samuel LANGER
金额：
$ 8.25万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7983702
关键词：
Advisory Committees CCNE1 gene Cells Chad Clinical Collaborations Communication Communities Consultations DNA Data Databases Deposition Development Direct Costs Disseminated Malignant Neoplasm Education and Outreach Educational process of instructing Evaluation Exhibits Faculty Festival Funding General Population Genes Goals Gold Grant Hybrids Image Magnetic Resonance Imaging Mails Microfluidics Mission Mus Museums Nanotechnology Nucleic Acids Pilot Projects Public Domains Publications Research Research Personnel Research Project Grants Resources Schools Science Series Sorting - Cell Movement Staging Students Vision Visit Work base cancer Biomedical Informatics Grid career clinically relevant data sharing design di-block copolymer flexibility high school in vivo interest lectures member mouse model nano nanomaterials nanomedicine nanoparticle neoplastic cell outreach programs public education tumor web site

项目摘要

OVERALL VISION FOR DEVELOPMENTAL ACTIVITIES Over the last 5 years of our CCNE, there has been a tremendous interest by researchers to join the consortium through pilot projects and/or collaborative research. We view such projects as an important adjunct of the CCNE's mission and from which full projects and important science can emerge. For example, in the past our consortium has funded the selected following projects: ¿ Paula Hammond and Dane Wittrup (pilot project) on functionalized linear-dendritic diblock copolymers for tumor-selective nucleic acid delivery. One ofthe postdocs (Greg Thurber) now works in the Weissleder lab and confinues interactions (85, 86) ¿ Stephen Lippard (pilot project) on functionalizing gold nanoparticles with DNA duplexes containing tethered, releasable plafinum conjugates at their termini in collaboration with Chad Mirkin at Northwestern CCNE (87) ¿ Robert Westen/elt (pilot project) on hybrid integrated circuit/microfluidic chips forthe manipulation of cells (88, 89) ¿ Sridhar Ramaswamy (pilot project) on nanomodels of metastatic cancer (90) ¿ Mehmet Toner and Daniel Haber (pilot project) on microfluidic sorting of circulating tumor cells. This original pilot project has resulted in several high impact publications (91-93) and funding outside the consortium, including a recent SU2C grant involving several CCNE members (Bhatia, Weissleder). Pilot, Alliance Challenge and other exploratory projects provide a mechanism by which to attract new researchers and to rapidly fund the most promising ideas. The following section lists some of our general plans on continuing developmental activities.

发展活动的总体愿景在 CCNE 的过去 5 年里，研究人员对通过试点项目和/或合作研究加入联盟表现出了极大的兴趣，我们将此类项目视为 CCNE 使命的重要辅助，并从中获得完整的项目和重要的科学成果。例如，我们的联盟过去资助了以下选定的项目： ¿ Paula Hammond 和 Dane Wittrup（试点项目）研究用于肿瘤选择性核酸递送的功能化线性-树枝状二嵌段共聚物。其中一位博士后（Greg Thurber）现在在 Weissleder 实验室工作并继续相互作用 (85, 86)。 ¿ Stephen Lippard（试点项目）利用含有 DNA 双链体的金纳米颗粒进行功能化与 Chad Mirkin 合作，在其末端连接可释放的铂结合物西北 CCNE (87) ¿ Robert Westen/elt（试点项目）关于混合集成电路/微流控芯片，用于操纵细胞 (88, 89) ¿ Sridhar Ramaswamy（试点项目）关于转移性癌症的纳米模型 (90) ¿ Mehmet Toner 和 Daniel Haber（试点项目）研究循环肿瘤细胞的微流体分选。最初的试点项目已经产生了一些高影响力的出版物（91-93）和外部资金财团，包括最近涉及多名 CCNE 成员（Bhatia、Weissleder）的 SU2C 资助。试点、联盟挑战和其他探索性项目提供了吸引新人的机制。研究人员并快速资助最有前途的想法以下部分列出了我们关于持续发展活动的一些总体计划。