Emory Epithelial Pathobiology Research Development Center

埃默里大学上皮病理学研究发展中心

• 批准号: 8288323
• 负责人: CHARLES A PARKOS
• 金额: $ 50.38万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-23 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8288323
• 关键词: Advisory Committees; Annexins; Apoptosis; Apoptotic; Area; Biology; CCR6 gene; Categories; Cell Culture Techniques; Cell Proliferation; Childhood; Clinical Nutrition; Colitis; Collaborations; Communicable Diseases; Coupled; Critical Care; Development; Diabetes Mellitus; Diarrhea; Digestive System Disorders; Direct Costs; Endocrinology; Epithelial; Epithelial Cells; Epithelium; Financial Support; Flagellin; Fostering; Functional disorder; Funding; Future; GTP-Binding Proteins; Gastrointestinal tract structure; Gene Expression; Goals; Gold; Graft Rejection; Grant; Helicobacter Infections; Hepatic Fibrogenesis; Hepatitis C; Host Defense; Image Analysis; Individual; Infection; Inflammation; Inflammatory disease of the intestine; Institution; Intention; Intestines; Journals; Kidney; Liver; Lung; Lymphocyte; MMP9 gene; Medicine; Mission; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrology; Neurofibromin 2; Newsletter; Nox enzyme; Operative Surgical Procedures; Oxidation-Reduction; Oxidative Stress; Parkinsonian Disorders; Pathology; Pediatric Neurology; Peer Review; Physiological Processes; Physiology; Play; Productivity; Program Research Project Grants; Publishing; Purinergic P1 Receptors; Regulation; Research; Research Personnel; Research Support; Rodent; Role; Schools; Series; Services; Short Bowel Syndrome; Signal Transduction; Sodium; Structure; Structure of thyroid parafollicular cell; TLR5 gene; Telomerase; Tight Junctions; Ubiquitination; Universities; Urea; Work; Wound Healing; Yang; Zebrafish; base; cell motility; college; cost; falls; gastrointestinal system; glucagon-like peptide 1; immunoregulation; interest; medical schools; meetings; member; migration; neutrophil; non-alcoholic fatty liver; nutrition; programs; research and development; response; symposium; tumorigenesis; wound

The Emory Epithelial Pathobiology Research Development Center was established in June of 2003 as one of four newly funded Digestive Diseases Research Development Centers (DDRDCs) supported by the NIDDK. The goal of the Center is to provide core services to a group of highly specialized and interactive epithelial biologists and pathobiologists in the digestive system with the intention of enhancing research capability, promoting new research directions, and fostering collaboration and interaction among the investigators. Research supported by the Center is mainly focused on epithelial biology and pathobiology of the digestive tract with three overarching themes: Inflammation/Infection, Proliferation/ Differentiation, and Normal Physiology. The Center has three cores: (A) Gene Expression Analysis Core, (B) Image Analysis Core, and (C) Cell Culture Core. In the past few years, these cores have played crucial roles in the development of a digestive diseases-centered research program at Emory and significantly enhanced the research capability of Center members as demonstrated by their outstanding scientific productivity. At its inception, the Center had 9 established investigators (full members) and 5 junior investigators (junior members) with a combined annual direct costs of $2,965,972 (55% of which supported by NIDDK). To date, the Center has evolved into a group of 21 full members and 8 junior members spanning across Departments of Medicine (including Divisions of Digestive Diseases, Endocrinology, Nephrology, Pulmonary & Critical Care Medicine, and Infectious Diseases), Pathology, Physiology, Surgery, Pediatrics, and Neurology in the Emory University School of Medicine, and Department of Biology in the Emory College. The combined annual director costs of this competing renewal application are $8,862,960, 67.7% of which are funded by the NIDDK. Thus, in less than 4 years, the Center has more than doubled its membership and nearly tripled its base grant support. Importantly, since 2003, this group of investigators collectively published 441 original research articles in peer-reviewed journals, out of which 100 contained 2 or more authors that are members of the Center. Moreover, at least 124 of these published work used core services provided by the Center, the majority of which cited the contribution of the Center. The Center has also received substantial amounts of financial support from the institution (Office of the Dean, Chairs of Medicine and Pathology, and Division of Digestive Diseases) with which to implement a highly successful enrichment program including a Pilot/Feasibility Project Grant Program, Research Seminar Series, Annual Scientific Symposium and Advisory Committee Meeting, and periodic Newsletters. The continuation of the Center will therefore further increase the strength of digestive diseases research at Emory with a strong focus on areas within the missions supported by the NIDDK.

Emory上皮病理学研究开发中心于2003年6月成立，是NIDDK支持的四个新资助的消化疾病研究发展中心（DDRDC）之一。该中心的目的是为消化系统中的一组高度专业化和互动上皮生物学家和病理生物学家提供核心服务，以增强研究能力，促进新的研究方向以及促进研究人员之间的协作和互动。该中心支持的研究主要集中于具有三个总体主题的消化道上皮生物学和病理学：炎症/感染，增殖/分化和正常生理学。该中心有三个核心：（a）基因表达分析核心，（b）图像分析核心和（c）细胞培养核心。在过去的几年中，这些核心在以埃默里（Emory）为中心的消化疾病研究计划的发展中发挥了至关重要的作用，并显着增强了中心成员的研究能力，这是其出色的科学生产力所证明的。该中心成立于该中心，有9名已有的调查人员（完整成员）和5名初级调查人员（初级成员），年度直接成本合计为2,965,972美元（其中55％由NIDDK支持）。迄今为止，该中心已经演变成21个完整成员和8个初级成员，这些成员跨越医学部门（包括消化系统疾病，内分泌学，肾脏学，肾脏学，肺和重症监护医学以及感染性疾病），病理学，生理学，手术，手术，儿科以及埃默里大学医学学院的神经学和神经学。该竞争续签申请的合并年度董事成本为8,862,960美元，其中67.7％由NIDDK资助。因此，在不到4年的时间里，该中心的会员人数增加了一倍以上，几乎两倍增加了基本赠款的支持。重要的是，自2003年以来，这组研究人员在同行评审期刊上共同发表了441篇原始研究文章，其中100个包含2位或更多作者，这些作者是该中心的成员。此外，其中至少有124个发表的工作使用了该中心提供的核心服务，其中大多数引用了该中心的贡献。该中心还从该机构（院长办公室，医学和病理主席以及消化系统疾病的办公室）获得了大量财政支持，以实施非常成功的丰富计划，包括试验/可行性项目赠款计划，研究研讨会系列，年度科学介绍委员会和咨询委员会会议和定期新闻通讯。因此，该中心的延续将进一步提高埃默里（Emory）消化疾病研究的强度，重点关注NIDDK支持的任务内的领域。

项目成果

MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells.

• DOI: 10.1053/j.gastro.2010.11.054
• 发表时间: 2011-03
• 期刊: Gastroenterology
• 影响因子: 29.4
• 作者: Lee SJ;Ritter SL;Zhang H;Shim H;Hall RA;Yun CC
• 通讯作者: Yun CC

Targeted deletion of neuropeptide Y (NPY) modulates experimental colitis.

• DOI: 10.1371/journal.pone.0003304
• 发表时间: 2008-10-01
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Chandrasekharan B;Bala V;Kolachala VL;Vijay-Kumar M;Jones D;Gewirtz AT;Sitaraman SV;Srinivasan S
• 通讯作者: Srinivasan S

Epac1 mediates protein kinase A-independent mechanism of forskolin-activated intestinal chloride secretion.

• DOI: 10.1085/jgp.200910339
• 发表时间: 2010-01
• 期刊: The Journal of general physiology
• 作者: Hoque KM;Woodward OM;van Rossum DB;Zachos NC;Chen L;Leung GP;Guggino WB;Guggino SE;Tse CM
• 通讯作者: Tse CM

Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria.

• DOI: 10.1038/mi.2015.121
• 发表时间: 2016-07
• 期刊: Mucosal immunology
• 影响因子: 8
• 作者: Rios D;Wood MB;Li J;Chassaing B;Gewirtz AT;Williams IR
• 通讯作者: Williams IR

Blockade of adenosine A2B receptors ameliorates murine colitis.

• DOI: 10.1038/bjp.2008.227
• 发表时间: 2008-09
• 期刊: BRITISH JOURNAL OF PHARMACOLOGY
• 影响因子: 7.3
• 作者: Kolachala, V. L.;Ruble, B. K.;Vijay-Kumar, M.;Wang, L.;Mwangi, S.;Figler, H. E.;Figler, R. A.;Srinivasan, S.;Gewirtz, A. T.;Linden, J.;Merlin, D.;Sitaraman, S. V.
• 通讯作者: Sitaraman, S. V.