Metabolic and Cognitive Consequences of Sleep Loss

睡眠不足对代谢和认知的影响

基本信息

批准号：
8528706
负责人：
Kenneth P Wright
金额：
$ 50.77万
依托单位：
UNIVERSITY OF COLORADO
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8528706
关键词：
Accidents Address Adipose tissue Affect American Automobile Driving Award Behavior Behavioral Mechanisms Biological Body Weight Changes Carbohydrates Center for Translational Science Activities Chronic Clinical Clinical Research Cognition Cognitive Consumption Data Diabetes Mellitus Diet Disease Eating Energy Intake Energy Metabolism Euglycemic Clamping Fatty acid glycerol esters Glucose Glucose Clamp Glycerol Goals Grant Health Hepatic Hormonal Hormones Human Impaired cognition Impaired health Impairment Inflammation Insulin Resistance Knowledge Laboratories Lead Leptin Macronutrients Nutrition Mediator of activation protein Metabolic Metabolic syndrome Modeling Moods Nerve Obesity Outcome Outcome Measure Performance Physiological Process Productivity Protocols documentation Public Health Randomized Recommendation Recovery Research Risk Risk Factors Safety Schedule Schools Short-Term Memory Simulate Skeletal Muscle Sleep Sleep Deprivation Sleep Disorders Societies Staging System Task Performances Testing Theoretical model Time Tissues Translating United States National Institutes of Health Visual attention Weight Gain Work alertness balance testing base blood glucose regulation cognitive change cognitive function design energy balance executive function feeding ghrelin improved insulin sensitivity meetings novel oxidation pandemic disease prevent primary outcome relating to nervous system response secondary outcome sleep regulation stable isotope theories vigilance

项目摘要

DESCRIPTION (provided by applicant): Chronic sleep loss affects millions of Americans. Short sleep schedules are associated with increased risk of weight gain, obesity, diabetes, the metabolic syndrome, and accidents. It is unknown if the common and self- selected behavior of weekend recovery sleep helps to protect against the health and safety effects of sleep loss. Furthermore, we do not fully understand the physiological and behavioral mechanisms that contribute to the negative health effects associated with sleep loss nor do we fully understand the time course of how quickly changes in some of these physiological systems occur. Therefore, we have designed a randomized 14-16 day in- lab Clinical and Translational Research Center (CTRC) study that uses whole room calorimetric, hyperinsulinemic/euglycemic clamps and safety sensitive cognitive tests to address these critical deficiencies in our knowledge. The stage for the proposed research was set by our NIH ARRA grant "Heath and Safety Consequences of Sleep Loss" and our proposed project is a continuation of this research effort. The project addresses several themes outlined in NIH PA NUMBER: PA-10-152 "Diet Composition and Energy Balance" by testing the following specific hypotheses: i) chronic sleep loss will lead to positive energy balance-a physiological state contributing to weight gain and weekend recovery sleep will restore energy balance to near baseline levels; ii) chronic sleep loss will impair insulin sensitivity and weekend recovery sleep will restore insulin sensitivity to near baseline levels; iii) chronic sleep loss will impair cognition and weekend recovery sleep will restore performance levels to near baseline. This research effort is responsive to PA-10-152 by assessing effects of sleep deprivation on macronutrient consumption and effects of dietary composition on physiological responses to sleep loss. The proposed project also meets the following highest recommendations for future research in the NIH National Center on Sleep Disorders Research (NCSDR) 2003 plan: i) enhance understanding of the impact of reduced or restricted sleep on behavior, and neurobiologic and physiologic functions; and ii) mechanisms underlying aspects of chronic sleep deprivation on non-neural systems.

描述（由申请人提供）：慢性睡眠不足影响着数百万美国人。睡眠时间短会增加体重增加、肥胖、糖尿病、代谢综合征和事故的风险。目前尚不清楚周末恢复睡眠的常见和自我选择行为是否有助于防止睡眠不足对健康和安全的影响。此外，我们并不完全了解导致与睡眠不足相关的负面健康影响的生理和行为机制，也没有完全了解其中一些生理系统发生变化的速度的时间过程。因此，我们设计了一项为期 14-16 天的随机实验室临床和转化研究中心 (CTRC) 研究，该研究使用全室量热、高胰岛素/血糖正常钳夹和安全敏感的认知测试来解决我们知识中的这些关键缺陷。拟议研究的阶段是由我们的 NIH ARRA 拨款“睡眠不足的健康和安全后果”奠定的，我们拟议的项目是这项研究工作的延续。该项目通过测试以下具体假设来解决 NIH PA 编号：PA-10-152“饮食成分和能量平衡”中概述的几个主题：i) 慢性睡眠不足将导致积极的能量平衡——一种有助于体重增加和体重增加的生理状态。周末恢复睡眠将使能量平衡恢复到接近基线水平； ii) 慢性睡眠不足会损害胰岛素敏感性，周末恢复睡眠会将胰岛素敏感性恢复到接近基线水平； iii) 慢性睡眠不足会损害认知能力，周末恢复睡眠会将表现水平恢复到接近基线的水平。这项研究工作通过评估睡眠剥夺对大量营养素消耗的影响以及膳食成分对睡眠不足的生理反应的影响来响应 PA-10-152。拟议的项目还满足 NIH 国家睡眠障碍研究中心 (NCSDR) 2003 年计划中对未来研究的以下最高建议： i) 增强对睡眠减少或限制对行为、神经生物学和生理功能影响的理解； ii) 非神经系统慢性睡眠剥夺的潜在机制。