2013 Cell Biology of Megakaryocytes and Platelets GRC & GRS

2013年巨核细胞和血小板的细胞生物学GRC

• 批准号: 8450490
• 负责人: KATYA RAVID
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8450490
• 关键词: Academia; Attention; Basic Science; Biology; Blood Platelets; Cardiovascular Diseases; Cardiovascular Pathology; Caring; Cells; Cellular biology; Coagulation Process; Collaborations; Communities; Coupled; Cytoskeleton; Development; Discipline; Disease; Faculty; Future; Goals; Health; Hematological Disease; Inflammatory; Institutes; Island; Knowledge; Learning; Medical; Megakaryocytes; Megakaryocytopoieses; Mentors; Methods; Mexico; MicroRNAs; Mission; Myeloproliferative disease; Myocardial Infarction; Names; Oral; Pathologic; Pathology; Pharmacologic Substance; Prevention; Process; Request for Applications; Research; Research Personnel; Running; Science; Scientist; Signal Transduction; Solid; Stroke; Talents; Texas; Thrombopoiesis; Thrombosis; Thrombus; Time; Training; abstracting; bench to bedside; career; cost; embryonic stem cell; experience; frontier; genome wide association study; immune function; improved; innovation; insight; interdisciplinary approach; interest; meetings; mimetics; novel; novel therapeutics; programs; public health relevance; screening; sound; symposium; thrombocytosis; tool

DESCRIPTION (provided by applicant): Abnormal thrombopoiesis and thrombosis contribute to an array of hematological and cardiovascular pathologies, thus, requiring continued research and educational efforts. The Gordon Research Conference (GRC) on the Cell Biology of Megakaryocytes and Platelets is the premier scientific meeting focused on the biology of megakaryocytes (MKs) and the platelets that arise from them. This will be the 5th biennial meeting that brings together two groups of scientists with complimentary goals and interests. Our meeting will begin with processes governing megakaryopoiesis and thrombopoiesis, including from inducible pluripotent and embryonic stem cells, moving to novel computational and screening methods to study theses processes, transitioning to the cell biology of these cells in the context of the cytoskeleton, and then to newly identified signaling, inflammatory and immune functions in MKs and platelets. This plan then leads smoothly to a session centered on discoveries related to MK and platelet pathology. In addition, there is a whole session devoted to presentations of Hot Topics, selected from submitted abstracts. There are several innovative aspects to the planned meeting, including 1. The sessions cover within the same cluster processes that govern MK and platelet development and function, thus, allowing convergence of two audiences with overlapping interests, further increasing exchange of perspectives; 2. The translational potential is illustrated in a new session titled: From Bench to Bed Side, and talks, such as on novel therapeutic options for thrombocytosis associated with myeloproliferative neoplasm; 3. Emphasis on multidisciplinary approaches is exemplified in several sessions; and 4. Inclusion, for the first time, of a session titled: Breaking Paradigms in MK and Platelet Biolog provides opportunities to learn about, and discuss new paradigms that challenge older concepts in the field. The retention of the Gordon Research Seminar (GRS) for the 2013 meeting is important. This venue encourages promising trainees to participate more visibly in the program and possibly be encouraged to continue and develop a career in MK and platelet biology. A novel aspect in the GRS plan involves a talk on a historical overview of discovery in MK/platelet biology. Abstracts submitted by trainees will be scored by a panel, and selected for oral presentations, of which some will also present under Hot Topics in the GRC. Round table discussions with investigators will provide mentoring related to careers in academia and in pharmaceutical companies. Taken together, we believe that the planned GRC/GRS represent the Frontiers of Science for our discipline, with keen attention to mentoring. The GRS/GRC meetings take place from March 9-10th and 10-15th, 2013, respectively, at the historic Hotel Galvez, Galveston Island, Texas, located on the Gulf of Mexico. With the unique surroundings of wide beaches and numerous attractions on and near the island, this will be an exciting and memorable venue for all attendees.

描述（由申请人提供）：异常的血小板和血栓形成有助于一系列血液学和心血管病理，因此需要继续进行研究和教育工作。戈登研究会议（GRC）关于巨核细胞和血小板的细胞生物学是主要的科学会议，侧重于巨核细胞（MKS）的生物学（MKS）和来自它们的血小板。这将是第五次双年展会议，汇集了两组具有免费目标和兴趣的科学家。我们的会议将从统治巨核酸和血小板的过程开始，包括从诱导的多能和胚胎干细胞，转化为新的计算和筛查方法，以研究这些过程，并过渡到这些细胞的细胞生物学，并在细胞骨架的上下文中转变为新的识别和新识别的信号和不受欢迎的功能，并具有新的信号和不受欢迎。然后，该计划顺利地导致了以与MK和血小板病理相关的发现为中心的会议。此外，整个会议都致力于从提交摘要中选择的热门主题的演示。计划的会议有几个创新的方面，其中包括1个。在管理MK和血小板开发和功能的相同集群过程中的会议涵盖，因此，允许两个受众的融合以及重叠的利益，进一步增加观点的交流； 2。在一个新的会议上说明了翻译潜力：从长凳到床一侧，以及谈论，例如与骨髓增生性肿瘤相关的新型治疗选择； 3。在几个课程中举例说明了对多学科方法的重视；和4。首次包含在MK和Platelet Biolog中打破范式的会议，提供了学习的机会，并讨论了挑战该领域较旧概念的新范式。戈登研究研讨会（GRS）在2013年会议上的保留很重要。该场所鼓励有前途的学员更明显地参与该计划，并可能鼓励继续在MK和血小板生物学领域发展和发展职业。 GRS计划中的一个新颖方面涉及有关MK/血小板生物学发现的历史概述的演讲。受训者提交的摘要将由小组评分，并选择用于口头演示，其中一些人也将在GRC中的热门话题下呈现。与调查人员的圆桌讨论将提供与学术界和制药公司职业有关的指导。综上所述，我们认为计划中的GRC/GRS代表了我们学科的科学领域，并敏锐地关注指导。 GRS/GRC会议分别于2013年3月9日至10日至10日在德克萨斯州加尔维斯顿岛的历史悠久的酒店加尔维斯，位于墨西哥湾。在宽阔的海滩和岛附近众多景点的独特环境中，这将是所有与会者的激动人心且令人难忘的场所。